Antony M Dean

Devamani, T., Rauwerdink, A. M., Lunzer, M., Jones, B. J., Mooney, J. L., Tan, M. A. O., Zhang, Z. J., Xu, J. H., Dean, A. M. & Kazlauskas, R. J., Jan 27 2016, In: Journal of the American Chemical Society. 138, 3, p. 1046-1056 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Scopus citations

Evolution of a catalytic mechanism

Rauwerdink, A., Lunzer, M., Devamani, T., Jones, B., Mooney, J., Zhang, Z. J., Xu, J. H., Kazlauskas, R. J. & Dean, A. M., Apr 1 2016, In: Molecular biology and evolution. 33, 4, p. 971-979 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Molecular Evolution, Functional Synthesis of

Dean, A. M., Apr 14 2016, Encyclopedia of Evolutionary Biology. Elsevier Inc., p. 44-54 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Phenotypic plasticity as an adaptation to a functional trade-off

Yi, X. & Dean, A. M., Oct 3 2016, In: eLife. 5, OCTOBER2016, e19307.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2015

Tipping the mutation-selection balance: Limited migration increases the frequency of deleterious mutants

Cooper, J. D., Neuhauser, C., Dean, A. M. & Kerr, B., Sep 7 2015, In: Journal of Theoretical Biology. 380, p. 123-133 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Why the honey badger don't care: Convergent evolution of venom-targeted nicotinic acetylcholine receptors in mammals that survive venomous snake bites

Drabeck, D. H., Dean, A. M. & Jansa, S. A., Jun 1 2015, In: Toxicon. 99, p. 68-72 5 p., 5038.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2014

Evolution of a transition state: Role of lys100 in the active site of isocitrate dehydrogenase

Miller, S. P., Gonçalves, S., Matias, P. M. & Dean, A. M., May 26 2014, In: ChemBioChem. 15, 8, p. 1145-1153 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2013

Bounded population sizes, fluctuating selection and the tempo and mode of coexistence

Yi, X. & Dean, A. M., Oct 15 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 16945-16950 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Description of a riboflavin biosynthetic gene variant prevalent in the phylum proteobacteria

Brutinel, E. D., Dean, A. M. & Gralnick, J. A., Dec 2013, In: Journal of bacteriology. 195, 24, p. 5479-5486 8 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2012

Induced fit and the catalytic mechanism of isocitrate dehydrogenase

Gonçalves, S., Miller, S. P., Carrondo, M. A., Dean, A. M. & Matias, P. M., Sep 11 2012, In: Biochemistry. 51, 36, p. 7098-7115 18 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

2010

Evolution of enzymatic activities of testis-specific short-chain dehydrogenase/reductase in drosophila

Zhang, J., Yang, H., Long, M., Li, L. & Dean, A. M., Oct 2010, In: Journal of Molecular Evolution. 71, 4, p. 241-249 9 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Pervasive cryptic epistasis in molecular evolution

Lunzer, M., Brian Golding, G. & Dean, A. M., Oct 2010, In: PLoS Genetics. 6, 10, p. 1-10 10 p., e1001162.

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

The future of molecular evolution

Dean, A. M., Jun 2010, In: EMBO Reports. 11, 6, p. 409 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Unrestricted migration favours virulent pathogens in experimental metapopulations: Evolutionary genetics of a rapacious life history

Eshelman, C. M., Vouk, R., Stewart, J. L., Halsne, E., Lindsey, H. A., Schneider, S., Gualu, M., Dean, A. M. & Kerr, B., Aug 27 2010, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 365, 1552, p. 2503-2513 11 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

2009

Enzymatic characterization of a monomeric isocitrate dehydrogenase from Streptomyces lividans TK54

Zhang, B., Wang, B., Wang, P., Cao, Z., Huang, E., Hao, J., Dean, A. M. & Zhu, G., Nov 2009, In: Biochimie. 91, 11-12, p. 1405-1410 6 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Experimental evolution from the bottom up

Dykhuizen, D. E. & Dean, A. M., Dec 3 2009, Experimental Evolution: Concepts, Methods, and Applications of Selection Experiments: Concepts, Methods, and Applications of Selection Experiments. University of California Press, p. 67-89 23 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Transcription, translation, and the evolution of specialists and generalists

Zhong, S., Miller, S. P., Dykhuizen, D. E. & Dean, A. M., Dec 2009, In: Molecular biology and evolution. 26, 12, p. 2661-2678 18 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2008

The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products

Stoebel, D. M., Dean, A. M. & Dykhuizen, D. E., Mar 2008, In: Genetics. 178, 3, p. 1653-1660 8 p.

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

2007

An empirical test of the concomitantly variable codon hypothesis

Merlo, L. M. F., Lunzer, M. & Dean, A. M., Jun 26 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 10938-10943 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Mechanistic approaches to the study of evolution: The functional synthesis

Dean, A. M. & Thornton, J. W., Sep 2007, In: Nature Reviews Genetics. 8, 9, p. 675-688 14 p.

Research output: Contribution to journal › Review article › peer-review

275 Scopus citations

2006

Direct demonstration of an adaptive constraint

Miller, S. P., Lunzer, M. & Dean, A. M., Oct 20 2006, In: Science. 314, 5798, p. 458-461 4 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Local migration promotes competitive restraint in a host-pathogen 'tragedy of the commons'

Kerr, B., Neuhauser, C., Bohannan, B. J. M. & Dean, A. M., Jul 6 2006, In: Nature. 442, 7098, p. 75-78 4 p.

Research output: Contribution to journal › Article › peer-review

300 Scopus citations

The argRB of Escherichia coli is rare in isolates obtained from natural sources

Merlo, L. M. F., Sadowsky, M. J., Ferguson, J. A. & Dean, A. M., Jul 5 2006, In: Gene. 376 376, 2, p. 240-247 8 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2005

Evolution: The biochemical architecture of an ancient adaptive landscape

Lunzer, M., Miller, S. P., Felsheim, R. & Dean, A. M., Oct 21 2005, In: Science. 310, 5747, p. 499-501 3 p.

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Evolution: The biochemical architecture of an ancient adaptive landscape

Lunzer, M., Miller, S. P., Felsheim, R. & Dean, A. M., Oct 21 2005, In: Science. 310, 5747, p. 499-501 3 p.

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Protecting haploid polymorphisms in temporally variable environments

Dean, A. M., Feb 2005, In: Genetics. 169, 2, p. 1147-1156 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Selection in a cyclical environment: Possible impact of phenotypic lag on Darwinian fitness

Suiter, A. M. & Dean, A. M., Aug 1 2005, In: Journal of Molecular Evolution. 61, 2, p. 153-170 18 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

The selective cause of an ancient adaptation

Zhu, G., Golding, G. B. & Dean, A. M., Feb 25 2005, In: Science. 307, 5713, p. 1279-1282 4 p.

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

2004

Evolutionary genomics of ecological specialization

Zhong, S., Khodursky, A., Dykhuizen, D. E. & Dean, A. M., Aug 10 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 32, p. 11719-11724 6 p.

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Evolution of specialists in an experimental microcosm

Dykhuizen, D. E. & Dean, A. M., Aug 2004, In: Genetics. 167, 4, p. 2015-2026 12 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Evolving protein functional diversity in new genes of Drosophila

Zhang, J., Dean, A. M., Brunet, F. & Long, M., Nov 16 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 46, p. 16246-16250 5 p.

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Rapid identification and mapping of insertion sequences in Escherichia coli genomes using vectorette PCR

Zhong, S. & Dean, A. M., Jul 8 2004, In: BMC microbiology. 4, 26.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

The mitochondrial citrate transport protein: Probing the secondary structure of transmembrane domain III, identification of residues that likely comprise a portion of the citrate transport pathway, and development of a model for the putative TMDIII-TMDIII′ interface

Ma, C., Kotaria, R., Mayor, J. A., Eriks, L. R., Dean, A. M., Walters, D. E. & Kaplan, R. S., Jan 9 2004, In: Journal of Biological Chemistry. 279, 2, p. 1533-1540 8 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2003

Fitness consequences of a regulatory polymorphism in a seasonal environment

Suiter, A. M., Bänziger, O. & Dean, A. M., Oct 28 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 22, p. 12782-12786 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2002

Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase

Singh, S. K., Miller, S. P., Dean, A., Banaszak, L. J. & Laporte, D. C., Mar 1 2002, In: Journal of Biological Chemistry. 277, 9, p. 7567-7573 7 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Enzyme kinetics, substitutable resources and competition: From biochemistry to frequency-dependent selection in lac

Lunzer, M., Natarajan, A., Dykhuizen, D. E. & Dean, A. M., Sep 1 2002, In: Genetics. 162, 1, p. 485-499 15 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Nucleotide variations in the lxd region of Drosophila melanogaster: Characterization of a candidate modifier of lifespan

Tahoe, N. M. A., Dean, A. M. & Curtsinger, J. W., Sep 4 2002, In: Gene. 297, 1-2, p. 221-228 8 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

The pattern of amino acid replacements in α/β-barrels

Dean, A. M., Neuhauser, C., Grenier, E. & Golding, G. B., Nov 2002, In: Molecular biology and evolution. 19, 11, p. 1846-1864 19 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

2000

Enzyme evolution explained (sort of).

Dean, A. M. & Golding, G. B., 2000, In: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. p. 6-17 12 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Locations of the regulatory sites for isocitrate dehydrogenase kinase/phosphatase

Miller, S. P., Chen, R., Karschnia, E. J., Romfo, C., Dean, A. & LaPorte, D. C., Jan 14 2000, In: Journal of Biological Chemistry. 275, 2, p. 833-839 7 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Molecular-functional studies of adaptive genetic variation in prokaryotes and eukaryotes

Watt, W. B. & Dean, A. M., 2000, In: Annual Review of Genetics. 34, p. 593-622 30 p.

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Rapid evolution in plant chitinases: Molecular targets of selection in plant-pathogen coevolution

Bishop, J. G., Dean, A. M. & Mitchell-Olds, T., May 9 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5322-5327 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

295 Scopus citations

Antony M Dean

Research output

Search results