Brian R Thompson – Research output — Experts@Minnesota

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Emailthom1709umnedu

Research activity per year

12 Article
3 Chapter
1 Review article

16 results

2024
Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain
Bedada, F. B., Thompson, B. R., Mikkila, J. L., Chan, S., Choi, S. H., Toso, E. A., Kyba, M. & Metzger, J. M., Dec 2024, In: Scientific reports. 14, 1, 3915.
Research output: Contribution to journal › Article › peer-review

Open Access
2023
Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers
Hahn, D., Quick, J. D., Thompson, B. R., Crabtree, A., Hackel, B. J., Bates, F. S. & Metzger, J. M., Dec 2023, In: Skeletal muscle. 13, 1, 9.
Research output: Contribution to journal › Article › peer-review

Open Access
2022
Cardiac Sarcomere Signaling in Health and Disease
Martin, A. A., Thompson, B. R., Hahn, D., Angulski, A. B. B., Hosny, N., Cohen, H. & Metzger, J. M., Dec 2022, In: International journal of molecular sciences. 23, 24, 16223.
Research output: Contribution to journal › Review article › peer-review

Open Access
4 Scopus citations
Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers
Martin, A. A., Thompson, B. R., Davis, J. P., Vang, H., Hahn, D. & Metzger, J. M., Dec 2022, In: Scientific reports. 12, 1, 18116.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Scopus citations
2021
Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice
Goldblum, R. R., McClellan, M., White, K., Gonzalez, S. J., Thompson, B. R., Vang, H. X., Cohen, H., Higgins, L. A., Markowski, T. W., Yang, T. Y., Metzger, J. M. & Gardner, M. K., Aug 9 2021, In: Developmental Cell. 56, 15, p. 2252-2266.e6
Research output: Contribution to journal › Article › peer-review

Open Access
19 Scopus citations
2020
Advancing physiological maturation in human induced pluripotent stem cell-derived cardiac muscle by gene editing an inducible adult troponin isoform switch
Wheelwright, M., Mikkila, J., Bedada, F. B., Mandegar, M. A., Thompson, B. R. & Metzger, J. M., Oct 1 2020, In: STEM CELLS. 38, 10, p. 1254-1266 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
14 Scopus citations
Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle
Vetter, A. D., Martin, A. A., Thompson, B. R., Thomas, D. D. & Metzger, J. M., Oct 2020, In: Journal of Molecular and Cellular Cardiology. 147, p. 49-61 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
12 Scopus citations
2019
Cytoplasmic nucleic acid-based XNAs directly enhance live cardiac cell function by a Ca ²⁺ cycling-independent mechanism via the sarcomere
Thompson, B. R., Soller, K. J., Vetter, A., Yang, J., Veglia, G., Bowser, M. & Metzger, J. M., May 2019, In: Journal of Molecular and Cellular Cardiology. 130, p. 1-9 9 p.
Research output: Contribution to journal › Article › peer-review
Gene transfer of calcium-binding proteins into adult cardiac myocytes
Thompson, B. R., Cohen, H., Angulski, A. B. B. & Metzger, J. M., 2019, Methods in Molecular Biology. Humana Press Inc., p. 187-205 19 p. (Methods in Molecular Biology; vol. 1929).
Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access
1 Scopus citations
2018
TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility
Vetter, A. D., Houang, E. M., Sell, J. J., Thompson, B. R., Sham, Y. Y. & Metzger, J. M., Apr 10 2018, In: Biophysical journal. 114, 7, p. 1646-1656 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
6 Scopus citations
2017
Molecular mechanism of sarcomeric cardiomyopathies
Thompson, B. R., Asp, M. L. & Metzger, J. M., Jun 1 2017, Congestive Heart Failure and Cardiac Transplantation: Clinical, Pathology, Imaging and Molecular Profiles. Springer International Publishing, p. 151-160 10 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Scopus citations
2016
Sarcomere neutralization in inherited cardiomyopathy: Small-molecule proof-of-concept to correct hyper-Ca²⁺-sensitive myofilaments
Thompson, B. R., Martindale, J. & Metzger, J. M., Jul 2016, In: American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H36-H43
Research output: Contribution to journal › Article › peer-review

Open Access
11 Scopus citations
2015
Ca²⁺regulation of the cardiac thin filament
Vetter, A. D., Thompson, B. R. & Metzger, J. M., Jan 1 2015, Cardiac Cytoarchitecture: How to Maintain a Working Heart. Springer International Publishing, p. 89-108 20 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Early detection of myocardial bioenergetic deficits: A 9.4 tesla complete non invasive ³¹P MR spectroscopy study in mice with muscular dystrophy
Cui, W., Jang, A., Zhang, P., Thompson, B., Townsend, D., Metzger, J. M. & Zhang, J., Aug 11 2015, In: PloS one. 10, 8, e0135000.
Research output: Contribution to journal › Article › peer-review

Open Access
8 Scopus citations
2014
Cell biology of sarcomeric protein engineering: Disease modeling and therapeutic potential
Thompson, B. R. & Metzger, J. M., Sep 2014, In: Anatomical Record. 297, 9, p. 1663-1669 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
10 Scopus citations
Molecular determinants of cardiac myocyte performance as conferred by isoform-specific tni residues
Thompson, B. R., Houang, E. M., Sham, Y. Y. & Metzger, J. M., May 20 2014, In: Biophysical journal. 106, 10, p. 2105-2114 10 p.
Research output: Contribution to journal › Article › peer-review
11 Scopus citations

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