Photo of Charles A Day
20042020

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Personal profile

Research interests

Aneuploidy is a major contributing factor to metastatic progression, and is found in ninety percent of solid cancerous tumors.  For a diploid cell to become an colony of aneuploid tumor cells, the cell must both (1) mis-segregate a chromosome and (2) avoid the p53-dependent cell cycle arrest that is normally triggered in response to inadvertently becoming aneuploid.  I am actively examining how somatic cells both regulate chromosome segregation and trigger p53 accumulation when chromosomes mis-segregate.  This work involves identifying and characterizing cancer-associated mutations that impair these two processes.  I have considerable expertise in the fields of cell biology, mitosis and cell cycle, quantitative fluorescence microscopy and membrane biophysics.

Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research interests

  • Histone H3.3
  • Aneuploidy
  • ATRX
  • Cancer
  • p53
  • glioblastoma
  • mitosis

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