Elizabeth A Ambrose

Associate Professor, Medicinal Chemistry

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Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

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1 Active
6 Finished

Chemical Methods to Characterize Penicillin-Binding Protein Function and Interactions
Carlson, E. E. & Ambrose, E. A.
NIH NIGMS NATL INST OF GENERAL
9/18/20 → 6/30/24
Project: Research project
Spaciotemporal Regulation of Specific Penicillin Binding Protein (PBP) Function Determined by New Activity-Based Approaches
Carlson, E. E. & Ambrose, E. A.
NIH NIGMS NATL INST OF GENERAL
9/1/18 → 8/31/20
Project: Research project
Chemical Biology Consortium, Task Order #1
Georg, G., Ambrose, E. A., Gurvich, V. J., Hook, D. & Walters, M. A.
Leidos Biomedical Research, Inc.
10/10/09 → 1/11/10
Project: Research project
Anthrax Toxin Lethal Factor Inhibition Study
Ambrose, E. A., Finzel, B. C., Hook, D., Johnson, R. L. & Walters, M. A.
NIH Nat'l Inst of Allergy & Infect Dis
7/6/09 → 6/30/15
Project: Research project
Chemically Controlled Assembly of Therapeutic Protein Na
Wagner, C. R., Ambrose, E. A., Vallera, D. A., Lodge, T., Siegel, R. A. & Truhlar, D. G.
NIH NATIONAL CANCER INSTITUTE (NCI)
9/21/07 → 7/31/11
Project: Research project

28 Article
3 Comment/debate
2 Chapter
2 Conference contribution
More
- 1 Editorial
- 1 Review article

7-methylation of chenodeoxycholic acid derivatives yields a substantial increase in TGR5 receptor potency
Nakhi, A., Mcdermott, C. M., Stoltz, K. L., John, K., Hawkinson, J. E., Ambrose, E. A., Khoruts, A., Sadowsky, M. J. & Dosa, P. I., Jul 25 2019, In: Journal of medicinal chemistry. 62, 14, p. 6824-6830 7 p.
Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Botulinum neurotoxin, tetanus toxin, and anthrax lethal factor countermeasures
Ambrose, E. A., Jul 1 2017, Topics in Medicinal Chemistry. Springer- Verlag, p. 47-67 21 p. (Topics in Medicinal Chemistry; vol. 22).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))
Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In: Cell Chemical Biology. 24, 10, p. 1314 1 p.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
4 Scopus citations
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In: Cell Chemical Biology. 24, 10, p. 1259-1275.e6
Research output: Contribution to journal › Article › peer-review

Open Access
8 Scopus citations
Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors
Zhang, X. & Amin, E. A., Jan 1 2016, In: Journal of Molecular Graphics and Modelling. 63, p. 22-28 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations