Research output per year
Research output per year
- 1 - 50 out of 51 results
Search results
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2023
Conditional Loss of MEF2C Expression in Osteoclasts Leads to a Sex-Specific Osteopenic Phenotype
Maisuria, R., Norton, A., Shao, C., Bradley, E. W. & Mansky, K., Aug 2023, In: International journal of molecular sciences. 24, 16, 12686.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Identification of a novel, MSC-induced macrophage subtype via single-cell sequencing: implications for intervertebral disc degeneration therapy
Koroth, J., Chitwood, C., Kumar, R., Lin, W. H., Reves, B. T., Boyce, T., Reineke, T. M., Ellingson, A. M., Johnson, C. P., Stone, L. S., Chaffin, K. C., Simha, N. K., Ogle, B. M. & Bradley, E. W., 2023, In: Frontiers in Cell and Developmental Biology. 11, 1286011.Research output: Contribution to journal › Article › peer-review
Open Access -
Macrophages and Bone Remodeling
Weivoda, M. M. & Bradley, E. W., Mar 2023, In: Journal of Bone and Mineral Research. 38, 3, p. 359-369 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access19 Scopus citations -
Macrophages and Intervertebral Disc Degeneration
Koroth, J., Buko, E. O., Abbott, R., Johnson, C. P., Ogle, B. M., Stone, L. S., Ellingson, A. M. & Bradley, E. W., Jan 2023, In: International journal of molecular sciences. 24, 2, 1367.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations -
Phlpp1 Expression in Osteoblasts Plays a Modest Role in Bone Homeostasis
Karkache, I. Y., Molstad, D. H. H., Vu, E., Jensen, E. D. & Bradley, E. W., Dec 2023, In: JBMR Plus. 7, 12, e10806.Research output: Contribution to journal › Article › peer-review
Open Access -
The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages
Katoku-Kikyo, N., Lim, S., Yuan, C., Koroth, J., Nakagawa, Y., Bradley, E. W. & Kikyo, N., Dec 2023, In: PLoS biology. 21, 12, e3002419.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
GIRK3 deletion facilitates kappa opioid signaling in chondrocytes, delays vascularization and promotes bone lengthening in mice
Taylor, E. L., Weaver, S. R., Lorang, I. M., Arnold, K. M., Bradley, E. W., Marron Fernandez de Velasco, E., Wickman, K. & Westendorf, J. J., Jun 2022, In: Bone. 159, 116391.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Musculoskeletal Development and Skeletal Pathophysiology’s
Bradley, E. W., Aug 2022, In: International journal of molecular sciences. 23, 16, 9092.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Scopus citations -
2021
Chondrocytic and pharmacokinetic properties of Phlpp inhibitors
Taylor, E. L., Weaver, S. R., Zars, E. L., Turner, C. A., Buhrow, S. A., Reid, J. M., Bradley, E. W. & Westendorf, J. J., Sep 2021, In: Osteoarthritis and Cartilage Open. 3, 3, 100190.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Erratum to: Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth (Journal of Bone and Mineral Research, (2021), 36, 5, (986-999), 10.1002/jbmr.4248)
Weaver, S. R., Taylor, E. L., Zars, E. L., Arnold, K. M., Bradley, E. W. & Westendorf, J. J., Oct 2021, In: Journal of Bone and Mineral Research. 36, 10, p. 2100-2101 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Scopus citations -
Myeloid lineage ablation of phlpp1 regulates m-csf signaling and tempers bone resorption in female mice
Karkache, I. Y., Damodaran, J. R., Molstad, D. H. H., Mansky, K. C. & Bradley, E. W., Sep 2021, In: International journal of molecular sciences. 22, 18, 9702.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Pain and activity measurements
Molstad, D. H. H. & Bradley, E. W., 2021, Methods in Molecular Biology. Humana Press Inc., p. 291-299 9 p. (Methods in Molecular Biology; vol. 2221).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss
Hanson, M. K., Karkache, I. Y., Molstad, D. H. H., Norton, A. A., Mansky, K. C. & Bradley, E. W., Jun 2021, In: PloS one. 16, 6 June, e0251732.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth
Weaver, S. R., Taylor, E. L., Zars, E. L., Arnold, K. M., Bradley, E. W. & Westendorf, J. J., May 2021, In: Journal of Bone and Mineral Research. 36, 5, p. 986-999 14 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Serine/threonine phosphatases in osteoclastogenesis and bone resorption
Karkache, I. Y., Damodaran, J. R., Molstad, D. H. H. & Bradley, E. W., Mar 1 2021, In: Gene. 771, 145362.Research output: Contribution to journal › Review article › peer-review
11 Scopus citations -
2020
Hdac3 deletion in myeloid progenitor cells enhances bone healing in females and limits osteoclast fusion via Pmepa1
Molstad, D. H. H., Zars, E., Norton, A., Mansky, K. C., Westendorf, J. J. & Bradley, E. W., Dec 2020, In: Scientific reports. 10, 1, 21804.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL
Molstad, D. H. H., Mattson, A. M., Begun, D. L., Westendorf, J. J. & Bradley, E. W., Dec 18 2020, In: Journal of Biological Chemistry. 295, 51, p. 17713-17723 11 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2019
Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice
Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E. W., Jan 1 2019, In: Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice
Zhang, C., Smith, M. P., Zhou, G. K., Lai, A., Hoy, R. C., Mroz, V., Torre, O. M., Laudier, D. M., Bradley, E. W., Westendorf, J. J., Iatridis, J. C. & Illien-Jünger, S., Oct 1 2019, In: Cell Death and Disease. 10, 10, 754.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2018
DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes
Castillejo Becerra, C. M., Mattson, A. M., Molstad, D. H. H., Lorang, I. M., Westendorf, J. J. & Bradley, E. W., Sep 2018, In: Journal of Cellular Biochemistry. 119, 9, p. 7470-7478 9 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity
McGee-Lawrence, M. E., Pierce, J. L., Yu, K., Culpepper, N. R., Bradley, E. W. & Westendorf, J. J., Apr 2018, In: Journal of Cellular Physiology. 233, 4, p. 2671-2680 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development
Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano-Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H. J., Karperien, M., Krych, A. J., Westendorf, J. J., Noelle Larson, A. & Van Wijnen, A. J., Jan 1 2018, In: Journal of Biological Chemistry. 293, 49, p. 19001-19011 11 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Osteoblasts: Function, development, and regulation
Bradley, E. W., Westendorf, J. J., Van Wijnen, A. J. & Dudakovic, A., Jan 1 2018, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. Wiley, p. 31-37 7 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
8 Scopus citations -
Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis
Hwang, S. M., Feigenson, M., Begun, D. L., Shull, L. C., Culley, K. L., Otero, M., Goldring, M. B., Ta, L. E., Kakar, S., Bradley, E. W. & Westendorf, J. J., May 2018, In: Journal of Orthopaedic Research. 36, 5, p. 1487-1497 11 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2017
Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development
Feigenson, M., Shull, L. C., Taylor, E. L., Camilleri, E. T., Riester, S. M., van Wijnen, A. J., Bradley, E. W. & Westendorf, J. J., Dec 2017, In: Journal of Bone and Mineral Research. 32, 12, p. 2453-2465 13 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes
Carpio, L. R., Bradley, E. W. & Westendorf, J. J., Jan 2 2017, In: Connective Tissue Research. 58, 1, p. 27-36 10 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice
Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., Lowe, V., Tchkonia, T., Westendorf, J. J. & Kirkland, J. L., Jun 1 2017, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 6, p. 780-785 6 p.Research output: Contribution to journal › Article › peer-review
Open Access239 Scopus citations -
2016
Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
Carpio, L. R., Bradley, E. W., McGee-Lawrence, M. E., Weivoda, M. M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., Van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In: Science signaling. 9, 440, ra79.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Identification of differentially methylated regions in new genes associated with knee osteoarthritis
Bonin, C. A., Lewallen, E. A., Baheti, S., Bradley, E. W., Stuart, M. J., Berry, D. J., van Wijnen, A. J. & Westendorf, J. J., Jan 15 2016, In: Gene. 576, 1, p. 312-318 7 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis
Bradley, E. W., Carpio, L. R., McGee-Lawrence, M. E., Castillejo Becerra, C., Amanatullah, D. F., Ta, L. E., Otero, M., Goldring, M. B., Kakar, S. & Westendorf, J. J., Jun 1 2016, In: Osteoarthritis and Cartilage. 24, 6, p. 1021-1028 8 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
Fang, D., Gan, H., Lee, J. H., Han, J., Wang, Z., Riester, S. M., Jin, L., Chen, J., Zhou, H., Wang, J., Zhang, H., Yang, N., Bradley, E. W., Ho, T. H., Rubin, B. P., Bridge, J. A., Thibodeau, S. N., Ordog, T., Chen, Y., Van Wijnen, A. J., & 4 others, Jun 10 2016, In: Science. 352, 6291, p. 1344-1348 5 p.Research output: Contribution to journal › Article › peer-review
Open Access187 Scopus citations -
2015
Deletion of the PH-domain and leucine-rich repeat protein phosphatase 1 (Phlpp1) increases fibroblast growth factor (Fgf) 18 expression and promotes chondrocyte proliferation
Bradley, E. W., Carpio, L. R., Newton, A. C. & Westendorf, J. J., Jun 26 2015, In: Journal of Biological Chemistry. 290, 26, p. 16272-16280 9 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Epigenetic control of skeletal development by the histone methyltransferase Ezh2
Dudakovic, A., Camilleri, E. T., Xu, F., Riester, S. M., McGee-Lawrence, M. E., Bradley, E. W., Paradise, C. R., Lewallen, E. A., Thaler, R., Deyle, D. R., Larson, A. N., Lewallen, D. G., Dietz, A. B., Stein, G. S., Montecino, M. A., Westendorf, J. J. & Van Wijnen, A. J., Nov 13 2015, In: Journal of Biological Chemistry. 290, 46, p. 27604-27617 14 p.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification
Bradley, E. W., Carpio, L. R., Olson, E. N. & Westendorf, J. J., Jan 2 2015, In: Journal of Biological Chemistry. 290, 1, p. 118-126 9 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Histone deacetylases in bone development and skeletal disorders
Bradley, E. W., Carpio, L. R., Van Wijnen, A. J., McGee-Lawrence, M. E. & Westendorf, J. J., Sep 9 2015, In: Physiological Reviews. 95, 4, p. 1359-1381 23 p.Research output: Contribution to journal › Article › peer-review
119 Scopus citations -
2014
Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice
McGee-Lawrence, M. E., Carpio, L. R., Bradley, E. W., Dudakovic, A., Lian, J. B., van Wijnen, A. J., Kakar, S., Hsu, W. & Westendorf, J. J., Sep 2014, In: Bone. 66, p. 277-286 10 p.Research output: Contribution to journal › Article › peer-review
41 Scopus citations -
2013
Corrigendum to "Histone deacetylase 3 is required for maintenance of bone mass during aging" [Bone 52 (2013) 296-307]
McGee-Lawrence, M. E., Bradley, E. W., Dudakovic, A., Carlson, S. W., Ryan, Z. C., Kumar, R., Dadsetan, M., Yaszemski, M. J., Chen, Q., An, K. N. & Westendorf, J. J., Mar 2013, In: Bone. 53, 1, p. 320 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Histone deacetylase 3 is required for maintenance of bone mass during aging
McGee-Lawrence, M. E., Bradley, E. W., Dudakovic, A., Carlson, S. W., Ryan, Z. C., Kumar, R., Dadsetan, M., Yaszemski, M. J., Chen, Q., An, K. N. & Westendorf, J. J., Jan 1 2013, In: Bone. 52, 1, p. 296-307 12 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion
Bradley, E. W., Carpio, L. R. & Westendorf, J. J., Apr 5 2013, In: Journal of Biological Chemistry. 288, 14, p. 9572-9582 11 p.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
2011
Hdac-mediated control of endochondral and intramembranous ossification
Bradley, E. W., McGee-Lawrence, M. E. & Westendorf, J. J., Nov 14 2011, In: Critical Reviews in Eukaryotic Gene Expression. 21, 2, p. 101-113 13 p.Research output: Contribution to journal › Review article › peer-review
51 Scopus citations -
Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway
Bradley, E. W. & Drissi, M. H., Jun 2011, In: Journal of cellular physiology. 226, 6, p. 1683-1693 11 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway
Bradley, E. W. & Drissi, M. H., Jun 1 2011, In: Journal of Cellular Physiology. 226, 6, p. 1683-1693 11 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
2010
Transforming growth factor-β coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis
Ruan, M., Pederson, L., Bradley, E. W., Bamberger, A. M. & Oursler, M. J., Apr 1 2010, In: Endocrinology. 151, 4, p. 1713-1722 10 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-κB pathways
Bradley, E. W. & Drissi, M. H., Aug 1 2010, In: Molecular Endocrinology. 24, 8, p. 1581-1593 13 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
2008
Novel pro-survival functions of the kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway
Bradley, E. W., Ruan, M. M. & Oursler, M. J., Mar 21 2008, In: Journal of Biological Chemistry. 283, 12, p. 8055-8064 10 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Osteoclast culture and resorption assays
Bradley, E. W. & Oursler, M. J., Jan 1 2008, Osteoporosis: Methods and Protocols. Humana Press, p. 19-35 17 p. (Methods in Molecular Biology; vol. 455).Research output: Chapter in Book/Report/Conference proceeding › Chapter
50 Scopus citations -
PAK1 is a novel MEK-independent Raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival
Bradley, E. W., Ruan, M. M. & Oursler, M. J., Dec 1 2008, In: Journal of Cellular Physiology. 217, 3, p. 752-758 7 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival
Bradley, E. W., Ruan, M. M., Vrable, A. & Oursler, M. J., Jul 1 2008, In: Journal of Cellular Biochemistry. 104, 4, p. 1439-1451 13 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival
Gingery, A., Bradley, E. W., Pederson, L., Ruan, M., Horwood, N. J. & Oursler, M. J., Sep 10 2008, In: Experimental Cell Research. 314, 15, p. 2725-2738 14 p.Research output: Contribution to journal › Article › peer-review
157 Scopus citations -
2005
Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis
Oursler, M. J., Bradley, E. W., Elfering, S. L. & Giulivi, C., Jan 2005, In: American Journal of Physiology - Cell Physiology. 288, 1 57-1, p. C156-C168Research output: Contribution to journal › Article › peer-review
35 Scopus citations