George L Wilcox

2024

Development of opioid analgesic tolerance in rat to extended-release buprenorphine formulated for laboratory subjects

Larson, C. M., Barajas, C., Kitto, K. F., Wilcox, G. L., Fairbanks, C. A. & Peterson, C. D., Mar 2024, In: PloS one. 19, 3 March, e0298819.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Adeno-associated virus-mediated gene transfer of arginine decarboxylase to the central nervous system prevents opioid analgesic tolerance

Churchill, C. C., Peterson, C. D., Kitto, K. F., Pflepsen, K. R., Belur, L. R., McIvor, R. S., Vulchanova, L., Wilcox, G. L. & Fairbanks, C. A., 2023, In: Frontiers in Pain Research. 4, 1269017.

Research output: Contribution to journal › Article › peer-review

Open Access

Biodistribution of Agmatine to Brain and Spinal Cord after Systemic Delivery

Clements, B. M., Peterson, C. D., Kitto, K. F., Caye, L. D., Wilcox, G. L. & Fairbanks, C. A., Dec 1 2023, In: Journal of Pharmacology and Experimental Therapeutics. 387, 3, p. 328-336 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine

Peterson, C. D., Waataja, J. J., Kitto, K. F., Erb, S. J., Verma, H., Schuster, D., Churchill, C. C., Riedl, M. S., Belur, L. R., Wolf, D. A., McIvor, R. S., Vulchanova, L., Wilcox, G. L. & Fairbanks, C. A., Apr 5 2023, In: Molecular Therapy. 31, 4, p. 1123-1135 13 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2022

Central Nervous System Distribution of an Opioid Agonist Combination with Synergistic Activity

Griffith, J. I., Kim, M., Bruce, D. J., Peterson, C. D., Kitto, K. F., Mohammad, A. S., Rathi, S., Fairbanks, C. A., Wilcox, G. L. & Elmquist, W. F., Jan 1 2022, In: Journal of Pharmacology and Experimental Therapeutics. 380, 1, p. 34-46 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Editorial: Preclinical studies exploring the central and peripheral mechanisms of cancer pain

Diaz-delCastillo, M. & Wilcox, G. L., 2022, In: Frontiers in Pain Research. 3, 1121765.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Modifying quantitative sensory testing to investigate behavioral reactivity in a pediatric global developmental delay sample: Relation to peripheral innervation and chronic pain outcomes

Symons, F. J., Burkitt, C. C., Wilcox, G., McAdams, B., Wendelschafer-Crabb, G. & Kennedy, W. R., Dec 2022, In: Developmental psychobiology. 64, 8, e22329.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2021

Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain

Peterson, C. D., Kitto, K. F., Verma, H., Pflepsen, K., Delpire, E., Wilcox, G. L. & Fairbanks, C. A., 2021, In: Molecular Pain. 17

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Biodistribution of Adeno-Associated Virus Serotype 5 Viral Vectors following Intrathecal Injection

Pflepsen, K. R., Peterson, C. D., Kitto, K. F., Riedl, M. S., McIvor, R. S., Wilcox, G. L., Vulchanova, L. & Fairbanks, C. A., Oct 4 2021, In: Molecular pharmaceutics. 18, 10, p. 3741-3749 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Expression of and correlational patterns among neuroinflammatory, neuropeptide, and neuroendocrine molecules from cerebrospinal fluid in cerebral palsy

Goracke-Postle, C. J., Burkitt, C. C., Panoskaltsis-Mortari, A., Ehrhardt, M., Wilcox, G. L., Graupman, P., Partington, M. & Symons, F. J., Dec 2021, In: BMC neurology. 21, 1, 384.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR-DOR Heteromer

Akgün, E., Lunzer, M. M., Tian, D., Ansonoff, M., Pintar, J., Bruce, D., Hawkinson, J. E., Wilcox, G. L. & Portoghese, P. S., May 11 2021, In: Biochemistry. 60, 18, p. 1413-1419 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2020

Evidence for neurogenic inflammation in lichen planopilaris and frontal fibrosing alopecia pathogenic mechanism

Doche, I., Wilcox, G. L., Ericson, M., Valente, N. S., Romiti, R., McAdams, B. D. & Hordinsky, M. K., Mar 1 2020, In: Experimental Dermatology. 29, 3, p. 282-285 4 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Overexpression of the aryl hydrocarbon receptor in frontal fibrosing alopecia and lichen planopilaris: a potential pathogenic role for dioxins?: an investigational study of 38 patients

Doche, I., Pagliari, C., Hordinsky, M. K., Wilcox, G. L., Rivitti-Machado, M. C. M., Romiti, R., Valente, N. Y. S., Shaik, J. A., Saldanha, M. & Sotto, M. N., Jul 1 2020, In: Journal of the European Academy of Dermatology and Venereology. 34, 7, p. e326-e329

Research output: Contribution to journal › Letter › peer-review

9 Scopus citations

Sustained-release buprenorphine induces acute opioid tolerance in the mouse

Larson, C. M., Peterson, C. D., Kitto, K. F., Wilcox, G. L. & Fairbanks, C. A., Oct 15 2020, In: European Journal of Pharmacology. 885, 173330.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Topical Application of Loperamide/Oxymorphindole, Mu and Delta Opioid Receptor Agonists, Reduces Sensitization of C-fiber Nociceptors that Possess Na_V1.8

Uhelski, M. L., Bruce, D., Speltz, R., Wilcox, G. L. & Simone, D. A., Oct 15 2020, In: Neuroscience. 446, p. 102-112 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2019

AAV-mediated gene delivery to the spinal cord by intrathecal injection

Peterson, C. D., Skorput, A. G. J., Kitto, K. F., Wilcox, G. L., Vulchanova, L. & Fairbanks, C. A., 2019, Methods in Molecular Biology. Humana Press Inc., p. 199-207 9 p. (Methods in Molecular Biology; vol. 1950).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Agmatine preferentially antagonizes GluN2B-containing N-methyl-D-aspartate receptors in spinal cord

Waataja, J. J., Peterson, C. D., Verma, H., Goracke-Postle, C. J., Séguéla, P., Delpire, E., Wilcox, G. L. & Fairbanks, C. A., Feb 2019, In: Journal of neurophysiology. 121, 2, p. 662-671 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Bruce, D. J., Peterson, C. D., Kitto, K. F., Akgün, E., Lazzaroni, S., Portoghese, P. S., Fairbanks, C. A. & Wilcox, G. L., Sep 1 2019, In: Anesthesiology. 131, 3, p. 649-663 15 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Defining and Managing Pain in Stroke and Traumatic Brain Injury Research

Larson, C. M., Wilcox, G. L. & Fairbanks, C. A., Dec 1 2019, In: Comparative Medicine. 69, 6, p. 510-519 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Detailed method for intrathecal delivery of gene therapeutics by direct lumbar puncture in mice

Pflepsen, K. R., Peterson, C. D., Kitto, K. F., Vulchanova, L., Wilcox, G. L. & Fairbanks, C. A., 2019, Methods in Molecular Biology. Humana Press Inc., p. 305-312 8 p. (Methods in Molecular Biology; vol. 1937).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice

Shah, R. M., Peterson, C., Strom, A., Dillenburg, M., Finzel, B., Kitto, K. F., Fairbanks, C., Wilcox, G. & Wagner, C. R., Oct 16 2019, In: ACS Chemical Neuroscience. 10, 10, p. 4385-4393 9 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Interleukin-8 as a therapeutic target for chronic low back pain: Upregulation in human cerebrospinal fluid and pre-clinical validation with chronic reparixin in the SPARC-null mouse model

Krock, E., Millecamps, M., Anderson, K. M., Srivastava, A., Reihsen, T. E., Hari, P., Sun, Y. R., Jang, S. H., Wilcox, G. L., Belani, K. G., Beebe, D. S., Ouellet, J., Pinto, M. R., Kehl, L. J., Haglund, L. & Stone, L. S., May 2019, In: EBioMedicine. 43, p. 487-500 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

The Study of Pain in Rats and Mice

Larson, C. M., Wilcox, G. L. & Fairbanks, C. A., Dec 2019, In: Comparative Medicine. 69, 6, p. 555-570 16 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2017

A case-controlled comparison of postoperative analgesic dosing between girls with Rett syndrome and girls with and without developmental disability undergoing spinal fusion surgery

Barney, C. C., Merbler, A. M., Quest, K., Byiers, B. J., Wilcox, G. L., Schwantes, S., Roiko, S. A., Feyma, T., Beisang, A. & Symons, F. J., Mar 1 2017, In: Paediatric anaesthesia. 27, 3, p. 290-299 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

A case-controlled investigation of tactile reactivity in young children with and without global developmental delay

Barney, C. C., Tervo, R., Wilcox, G. L. & Symons, F. J., Sep 2017, In: American journal on intellectual and developmental disabilities. 122, 5, p. 409-421 13 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

Peterson, C. D., Kitto, K. F., Akgün, E., Lunzer, M. M., Riedl, M. S., Vulchanova, L., Wilcox, G. L., Portoghese, P. S. & Fairbanks, C. A., 2017, In: Pain. 158, 12, p. 2431-2441 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Evidence for a Role of Nerve Injury in Painful Intervertebral Disc Degeneration: A Cross-Sectional Proteomic Analysis of Human Cerebrospinal Fluid

Lim, T. K. Y., Anderson, K. M., Hari, P., Di Falco, M., Reihsen, T. E., Wilcox, G. L., Belani, K. G., LaBoissiere, S., Pinto, M. R., Beebe, D. S., Kehl, L. J. & Stone, L. S., Oct 2017, In: Journal of Pain. 18, 10, p. 1253-1269 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

In vivo optogenetic activation of Na_v1.8⁺ cutaneous nociceptors and their responses to natural stimuli

Uhelski, M. L., Bruce, D. J., Séguéla, P., Wilcox, G. L. & Simone, D. A., 2017, In: Journal of neurophysiology. 117, 6, p. 2218-2223 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2015

Analgesic synergy between opioid and α₂-adrenoceptors

Chabot-Doré, A. J., Schuster, D. J., Stone, L. S. & Wilcox, G. L., Jan 2015, In: British Journal of Pharmacology. 172, 2, p. 388-402 15 p.

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Can Biomarkers Differentiate Pain and No Pain Subgroups of Nonverbal Children with Cerebral Palsy? A Preliminary Investigation Based on Noninvasive Saliva Sampling

Symons, F. J., Elghazi, I., Reilly, B. G., Barney, C. C., Hanson, L., Panoskaltsis-Mortari, A., Armitage, I. M. & Wilcox, G. L., Feb 1 2015, In: Pain Medicine (United States). 16, 2, p. 249-256 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Dual allosteric modulation of opioid antinociceptive potency by α_2A-adrenoceptors

Chabot-Doré, A. J., Millecamps, M., Naso, L., Devost, D., Trieu, P., Piltonen, M., Diatchenko, L., Fairbanks, C. A., Wilcox, G. L., Hébert, T. E. & Stone, L. S., Aug 6 2015, In: Neuropharmacology. 99, p. 285-300 16 p., 5956.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors

Schuster, D. J., Metcalf, M. D., Kitto, K. F., Messing, R. O., Fairbanks, C. A. & Wilcox, G. L., Jan 2015, In: British Journal of Pharmacology. 172, 2, p. 642-653 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Substance P in keratosis follicularis spinulosa decalvans

Doche, I., Hordinsky, M., Wilcox, G. L., Valente, N. S. & Romiti, R., 2015, In: JAAD Case Reports. 1, 6, p. 327-328 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The Subjective Experience of Pain: An FMRI Study of Percept-Related Models and Functional Connectivity

Wilcox, C. E., Mayer, A. R., Teshiba, T. M., Ling, J., Smith, B. W., Wilcox, G. L. & Mullins, P. G., Nov 1 2015, In: Pain Medicine (United States). 16, 11, p. 2121-2133 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2014

Morphine and clonidine combination therapy improves therapeutic window in mice: Synergy in antinociceptive but not in sedative or cardiovascular effects

Stone, L. S., German, J. P., Kitto, K. F., Fairbanks, C. A. & Wilcox, G. L., Oct 9 2014, In: PloS one. 9, 10, e109903.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

2013

Agmatine: Clinical applications after 100 years in translation

Piletz, J. E., Aricioglu, F., Cheng, J. T., Fairbanks, C. A., Gilad, V. H., Haenisch, B., Halaris, A., Hong, S., Lee, J. E., Li, J., Liu, P., Molderings, G. J., Rodrigues, A. L. S., Satriano, J., Seong, G. J., Wilcox, G., Wu, N. & Gilad, G. M., Sep 2013, In: Drug Discovery Today. 18, 17-18, p. 880-893 14 p.

Research output: Contribution to journal › Review article › peer-review

195 Scopus citations

Effect of chronic pain on fentanyl self-administration in mice

Wade, C. L., Krumenacher, P., Kitto, K. F., Peterson, C. D., Wilcox, G. L. & Fairbanks, C. A., Nov 15 2013, In: PloS one. 8, 11, e79239.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs

Schuster, D. J., Kitto, K. F., Overland, A. C., Messing, R. O., Stone, L. S., Fairbanks, C. A. & Wilcox, G. L., 2013, In: Journal of Neuroscience. 33, 33, p. 13538-13546 9 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2012

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ Opioid receptors

Metcalf, M. D., Yekkirala, A. S., Powers, M. D., Kitto, K. F., Fairbanks, C. A., Wilcox, G. L. & Portoghese, P. S., Jul 18 2012, In: ACS Chemical Neuroscience. 3, 7, p. 505-509 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2010

Changes in the NMR metabolic profile of human microglial cells exposed to lipopolysaccharide or morphine

El Ghazi, I., Sheng, W., Hu, S., Reilly, B. G., Lokensgard, J. R., Rock, R. B., Peterson, P. K., Wilcox, G. L. & Armitage, I. M., Dec 2010, In: Journal of Neuroimmune Pharmacology. 5, 4, p. 574-581 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture

Vulchanova, L., Schuster, D. J., Belur, L. R., Riedl, M. S., Podetz-Pedersen, K. M., Kitto, K. F., Wilcox, G. L., McIvor, R. S. & Fairbanks, C. A., May 28 2010, In: Molecular Pain. 6, 31.

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Mechanisms of cancer pain

Schmidt, B. L., Hamamoto, D. T., Simone, D. A. & Wilcox, G. L., Jun 2010, In: Molecular interventions. 10, 3, p. 164-178 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

143 Scopus citations

2009

Clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord

Fairbanks, C. A., Kitto, K. F., Nguyen, H. O., Stone, L. S. & Wilcox, G. L., Mar 2009, In: Anesthesiology. 110, 3, p. 638-647 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Coexpression of α_2A-adrenergic and δ-opioid receptors in substance P-containing terminals in rat dorsal horn

Riedl, M. S., Schnell, S. A., Overland, A. C., Chabot-Doré, A. J., Taylor, A. M., Ribeiro-Da-Silva, A., Elde, R. P., Wilcox, G. L. & Stone, L. S., Apr 1 2009, In: Journal of Comparative Neurology. 513, 4, p. 385-398 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Erratum: Coexpression of α_2A-adrenergic and δ-opioid receptors in substance P-containing terminals in rat dorsal horn (Journal of Comparative Neurology (2009) vol. 513 (385-398))

Riedl, M. S., Schnell, S., Overland, A. C., Chabot-Doré, A. J., Taylor, A. M., Ribeiro-Da-Silva, A., Elde, R. P., Wilcox, G. L. & Stone, L. S., Jun 20 2009, In: Journal of Comparative Neurology. 514, 6, p. 674 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Immunoneutralization of agmatine sensitizes mice to μ-opioid receptor tolerance

Wade, C. L., Eskridge, L. L., Nguyen, H. O. X., Kitto, K. F., Stone, L. S., Wilcox, G. & Fairbanks, C. A., Nov 2009, In: Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 539-546 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Peripheral mechanisms of pain and analgesia

Stein, C., Clark, J. D., Oh, U., Vasko, M. R., Wilcox, G. L., Overland, A. C., Vanderah, T. W. & Spencer, R. H., Apr 2009, In: Brain Research Reviews. 60, 1, p. 90-113 24 p.

Research output: Contribution to journal › Review article › peer-review

Open Access