Research output per year
Research output per year
- 22 results
Search results
-
2024
R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts
Liu, Z. S., Sinha, S., Bannister, M., Song, A., Arriaga-Gomez, E., McKeeken, A. J., Bonner, E. A., Hanson, B. K., Sarchi, M., Takashima, K., Zong, D., Corral, V. M., Nguyen, E., Yoo, J., Chiraphapphaiboon, W., Leibson, C., McMahon, M. C., Rai, S., Swisher, E. M., Sachs, Z., & 10 others, 2024, In: Cancer Research. 84, 4, p. 577-597 21 p.Research output: Contribution to journal › Article › peer-review
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2023
PARP1 associates with R-loops to promote their resolution and genome stability
Laspata, N., Kaur, P., Mersaoui, S. Y., Muoio, D., Liu, Z. S., Bannister, M. H., Nguyen, H. D., Curry, C., Pascal, J. M., Poirier, G. G., Wang, H., Masson, J. Y. & Fouquerel, E., Mar 21 2023, In: Nucleic acids research. 51, 5, p. 2215-2237 23 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Saracatinib synergizes with enzalutamide to downregulate AR activity in CRPC
White, R. E., Bannister, M., Day, A., Bergom, H. E., Tan, V. M., Hwang, J., Dang Nguyen, H. & Drake, J. M., 2023, In: Frontiers in Oncology. 13, 1210487.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Identification of Formaldehyde-Induced DNA-RNA Cross-Links in the A/J Mouse Lung Tumorigenesis Model
Dator, R. P., Murray, K. J., Luedtke, M. W., Jacobs, F. C., Kassie, F., Nguyen, H. D., Villalta, P. W. & Balbo, S., Nov 21 2022, In: Chemical research in toxicology. 35, 11, p. 2025-2036 12 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2020
ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop
Matos, D. A., Zhang, J. M., Ouyang, J., Nguyen, H. D., Genois, M. M. & Zou, L., Feb 6 2020, In: Molecular Cell. 77, 3, p. 514-527.e4Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
2019
Targeting R-loop-associated ATR response in myelodysplastic syndrome
Nguyen, H. D., Zou, L. & Graubert, T. A., Apr 1 2019, In: Oncotarget. 10, 27, p. 2581-2582 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access10 Scopus citations -
2018
A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation
Kabeche, L., Nguyen, H. D., Buisson, R. & Zou, L., Jan 5 2018, In: Science. 359, 6371, p. 108-114 7 p.Research output: Contribution to journal › Article › peer-review
Open Access198 Scopus citations -
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner
Becker, J. R., Gallo, D., Leung, W., Croissant, T., Thu, Y. M., Nguyen, H. D., Starr, T. K., Brown, G. W. & Bielinsky, A. K., Jun 20 2018, In: Nucleic acids research. 46, 11, p. 5634-5650 17 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Getting a Genomic View of DNA Replication Stress
Zou, L. & Nguyen, H. D., Oct 18 2018, In: Molecular Cell. 72, 2, p. 201-203 3 p.Research output: Contribution to journal › Short survey › peer-review
Open Access1 Scopus citations -
Spliceosome mutations induce R loop-associated sensitivity to ATR inhibition in myelodysplastic syndromes
Nguyen, H. D., Leong, W. Y., Li, W., Reddy, P. N. G., Sullivan, J. D., Walter, M. J., Zou, L. & Graubert, T. A., Sep 15 2018, In: Cancer Research. 78, 18, p. 5363-5374 12 p.Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
2017
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
Yazinski, S. A., Comaills, V., Buisson, R., Genois, M. M., Nguyen, H. D., Ho, C. K., Kwan, T. T., Morris, R., Lauffer, S., Nussenzweig, A., Ramaswamy, S., Benes, C. H., Haber, D. A., Maheswaran, S., Birrer, M. J. & Zou, L., Feb 1 2017, In: Genes and Development. 31, 3, p. 318-332 15 p.Research output: Contribution to journal › Article › peer-review
Open Access278 Scopus citations -
Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
Nguyen, H. D., Yadav, T., Giri, S., Saez, B., Graubert, T. A. & Zou, L., Mar 2 2017, In: Molecular Cell. 65, 5, p. 832-847.e4Research output: Contribution to journal › Article › peer-review
Open Access179 Scopus citations -
2016
Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression
Thu, Y. M., Van Riper, S. K., Higgins, L. A., Zhang, T., Becker, J. R., Markowski, T. W., Nguyen, H. D., Griffin, T. J. & Bielinsky, A. K., May 10 2016, In: Cell reports. 15, 6, p. 1254-1265 12 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2015
Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing
Becker, J. R., Pons, C., Nguyen, H. D., Costanzo, M., Boone, C., Myers, C. L. & Bielinsky, A. K., Nov 2015, In: PLoS genetics. 11, 11, e1005659.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Noncovalent Interactions with SUMO and Ubiquitin Orchestrate Distinct Functions of the SLX4 Complex in Genome Maintenance
Ouyang, J., Garner, E., Hallet, A., Nguyen, H. D., Rickman, K. A., Gill, G., Smogorzewska, A. & Zou, L., Jan 8 2015, In: Molecular Cell. 57, 1, p. 108-122 15 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
2014
Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair
Becker, J. R., Nguyen, H. D., Wang, X. & Bielinsky, A. K., Jun 1 2014, In: Cell Cycle. 13, 11, p. 1737-1748 12 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry
Maréchal, A., Li, J. M., Ji, X. Y., Wu, C. S., Yazinski, S. A., Nguyen, H. D., Liu, S., Jiménez, A. E., Jin, J. & Zou, L., Jan 23 2014, In: Molecular Cell. 53, 2, p. 235-246 12 p.Research output: Contribution to journal › Article › peer-review
Open Access188 Scopus citations -
SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway
Wu, C. S., Ouyang, J., Mori, E., Nguyen, H. D., Maréchal, A., Hallet, A., Chen, D. J. & Zou, L., Jul 1 2014, In: Genes and Development. 28, 13, p. 1472-1484 13 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
2013
Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1
Shiotani, B., Nguyen, H. D., Håkansson, P., Maréchal, A., Tse, A., Tahara, H. & Zou, L., May 30 2013, In: Cell reports. 3, 5, p. 1651-1662 12 p.Research output: Contribution to journal › Article › peer-review
Open Access111 Scopus citations -
2010
Damage-specific modification of PCNA
Das-Bradoo, S., Nguyen, H. D. & Bielinsky, A. K., Sep 15 2010, In: Cell Cycle. 9, 18, p. 3698-3703 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
Defects in DNA ligase i trigger PCNA ubiquitylation at Lys 107
Das-Bradoo, S., Nguyen, H. D., Wood, J. L., Ricke, R. M., Haworth, J. C. & Bielinsky, A. K., Jan 2010, In: Nature Cell Biology. 12, 1, p. 74-79 6 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
HDM2 ERKs PCNA
Nguyen, H. D. & Bielinsky, A. K., Aug 23 2010, In: Journal of Cell Biology. 190, 4, p. 487-489 3 p.Research output: Contribution to journal › Comment/debate › peer-review
2 Scopus citations