Research output per year
Research output per year
- 1 - 50 out of 177 results
Search results
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2024
Tau Phosphorylation Patterns in the Rat Cerebral Cortex After Traumatic Brain Injury and Sodium Selenate Effects: An Epibios4rx Project 2 Study
EpiBioS4Rx Study Group, Jan 1 2024, In: Journal of neurotrauma. 41, 1-2, p. 222-243 22 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2023
Comment on the formulation of intravenous topiramate for the treatment of status epilepticus
Cloyd, J., Pipkin, J. D. & Sen, D., Aug 2023, In: Epilepsy and Behavior. 145, 109314.Research output: Contribution to journal › Letter › peer-review
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Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model
EpiBioS4Rx Study Group, Aug 1 2023, In: Journal of Pharmacology and Experimental Therapeutics. 386, 2, p. 259-265 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Why ketamine
Coles, L., Rosenthal, E. S., Bleck, T. P., Elm, J., Zehtabchi, S., Chamberlain, J., Cloyd, J., Shinnar, S., Silbergleit, R. & Kapur, J., Apr 2023, In: Epilepsy and Behavior. 141, 109066.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
2022
Biological Variation in Peripheral Inflammation and Oxidative Stress Biomarkers in Individuals with Gaucher Disease
Sahasrabudhe, S. A., Terluk, M. R., Rudser, K. D., Cloyd, J. C. & Kartha, R. V., Aug 2022, In: International journal of molecular sciences. 23, 16, 9189.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Estimating the National Population of Hospitalized Chronic Baclofen Users: A Cross-Sectional Analysis of a Commercial Claims Database
Schmitz, N., Artz, M., Walsh, K., Gaudana, S., Cloyd, J., Schrogie, J. & Kriel, R. L., Jun 2022, In: Drugs - Real World Outcomes. 9, 2, p. 307-314 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs
Vuu, I., Patterson, E. E., Wu, C. Y., Zolkowska, D., Leppik, I. E., Rogawski, M. A., Worrell, G. A., Kremen, V., Cloyd, J. C. & Coles, L. D., Feb 1 2022, In: Journal of Pharmacology and Experimental Therapeutics. 380, 2, p. 104-113 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Translational and clinical pharmacology considerations in drug repurposing for X-linked adrenoleukodystrophy—A rare peroxisomal disorder
Tieu, J. H., Sahasrabudhe, S. A., Orchard, P. J., Cloyd, J. C. & Kartha, R. V., Jun 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2552-2563 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
2021
A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure
Sathe, A. G., Brundage, R. C., Ivaturi, V., Cloyd, J. C., Chamberlain, J. M., Elm, J. J., Silbergleit, R., Kapur, J. & Coles, L. D., Jul 2021, In: Clinical and translational science. 14, 4, p. 1444-1451 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Article quantitative assessment of occipital metabolic and energetic changes in parkinson’s patients, using in vivo31p MRS-based metabolic imaging at 7t
Zhu, X. H., Lee, B. Y., Tuite, P., Coles, L., Sathe, A. G., Chen, C., Cloyd, J., Low, W. C., Steer, C. J. & Chen, W., 2021, In: Metabolites. 11, 3, 145.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
A team science approach to discover novel targets for infantile spasms (IS)
The CURE Infantile Spasms Consortium, CURE Staff, Mar 2021, In: Epilepsia Open. 6, 1, p. 49-61 13 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Characterizing Baclofen Withdrawal: A National Survey of Physician Experience
Schmitz, N. S., Krach, L. E., Coles, L. D., Schrogie, J., Cloyd, J. C. & Kriel, R. L., Sep 2021, In: Pediatric Neurology. 122, p. 106-109 4 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Early Exposure of Fosphenytoin, Levetiracetam, and Valproic Acid After High-Dose Intravenous Administration in Young Children With Benzodiazepine-Refractory Status Epilepticus
Sathe, A. G., Mishra, U., Ivaturi, V., Brundage, R. C., Cloyd, J. C., Elm, J. J., Chamberlain, J. M., Silbergleit, R., Kapur, J., Lowenstein, D. H., Shinnar, S., Cock, H. R., Fountain, N. B., Babcock, L. & Coles, L. D., Jun 2021, In: Journal of Clinical Pharmacology. 61, 6, p. 763-768 6 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Early Neurologic Recovery, Practice Pattern Variation, and the Risk of Endotracheal Intubation Following Established Status Epilepticus
Rosenthal, E. S., Elm, J. J., Ingles, J., Rogers, A. J., Terndrup, T. E., Holsti, M., Thomas, D. G., Babcock, L., Okada, P. J., Lipsky, R. H., Miller, J. B., Hickey, R. W., Barra, M. E., Bleck, T. P., Cloyd, J. C., Silbergleit, R., Lowenstein, D. H., Coles, L. D., Kapur, J., Shinnar, S., & 1 others, May 11 2021, In: Neurology. 96, 19, p. E2372-E2386Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
N-acetylcysteine reverses the mitochondrial dysfunction induced by very long-chain fatty acids in murine oligodendrocyte model of adrenoleukodystrophy
Zhou, J., Terluk, M. R., Orchard, P. J., Cloyd, J. C. & Kartha, R. V., Dec 2021, In: Biomedicines. 9, 12, 1826.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters
Cloyd, J., Haut, S., Carrazana, E. & Rabinowicz, A. L., Apr 2021, In: Epilepsia. 62, 4, p. 846-856 11 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial
Sathe, A. G., Underwood, E., Coles, L. D., Elm, J. J., Silbergleit, R., Chamberlain, J. M., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Rosenthal, E. S., Conwit, R. A., Bleck, T. P. & Cloyd, J. C., Mar 2021, In: Epilepsia. 62, 3, p. 795-806 12 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Population Pharmacokinetic Analysis of N-Acetylcysteine in Pediatric Patients With Inherited Metabolic Disorders Undergoing Hematopoietic Stem Cell Transplant
Sahasrabudhe, S. A., Kartha, R. V., Ng, M., Basso, L. M., Mishra, U., Cloyd, J. C., Orchard, P. J., Brundage, R. C. & Coles, L. D., Dec 2021, In: Journal of Clinical Pharmacology. 61, 12, p. 1638-1645 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2020
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial
Neurological Emergencies Treatment Trials, Apr 11 2020, In: The Lancet. 395, 10231, p. 1217-1224 8 p.Research output: Contribution to journal › Article › peer-review
Open Access135 Scopus citations -
GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies
Johnson, P. H., Weinreb, N. J., Cloyd, J. C., Tuite, P. J. & Kartha, R. V., Feb 2020, In: Molecular Genetics and Metabolism. 129, 2, p. 35-46 12 p.Research output: Contribution to journal › Review article › peer-review
11 Scopus citations -
N-acetylcysteine provides cytoprotection in murine oligodendrocytes through heme oxygenase-1 activity
Zhou, J., Terluk, M. R., Basso, L., Mishra, U. R., Orchard, P. J., Cloyd, J. C., Schröder, H. & Kartha, R. V., Jul 2020, In: Biomedicines. 8, 7, 240.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Neurochemical abnormalities in patients with type 1 Gaucher disease on standard of care therapy
Kartha, R. V., Joers, J., Terluk, M. R., Travis, A., Rudser, K., Tuite, P. J., Weinreb, N. J., Jarnes, J. R., Cloyd, J. C. & Öz, G., May 1 2020, In: Journal of Inherited Metabolic Disease. 43, 3, p. 564-573 10 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Patients with Gaucher disease display systemic oxidative stress dependent on therapy status
Kartha, R. V., Terluk, M. R., Brown, R., Travis, A., Mishra, U. R., Rudser, K., Lau, H., Jarnes, J. R., Cloyd, J. C. & Weinreb, N. J., Dec 2020, In: Molecular Genetics and Metabolism Reports. 25, 100667.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease—A Pilot Study
Sathe, A. G., Tuite, P., Chen, C., Ma, Y., Chen, W., Cloyd, J., Low, W. C., Steer, C. J., Lee, B. Y., Zhu, X. H. & Coles, L. D., Jun 1 2020, In: Journal of Clinical Pharmacology. 60, 6, p. 744-750 7 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus
Sathe, A. G., Elm, J. J., Cloyd, J. C., Chamberlain, J. M., Silbergleit, R., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Conwit, R. A., Bleck, T. P. & Coles, L. D., Jun 1 2020, In: Epilepsia. 61, 6, p. e66-e70Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2019
Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study
EpiBioS4Rx Study Group Investigators, Mar 2019, In: Neurobiology of Disease. 123, p. 115-121 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access76 Scopus citations -
Intranasal coadministration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats
Rautiola, D., Maglalang, P. D., Cheryala, N., Nelson, K. M., Georg, G. I., Fine, J. M., Svitak, A. L., Faltesek, K. A., Hanson, L. R., Mishra, U., Coles, L. D., Cloyd, J. C. & Siegel, R. A., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 796-805 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Lessons from the Established Status Epilepticus Treatment Trial
Cock, H. R., Coles, L. D., Elm, J., Silbergleit, R., Chamberlain, J. M., Cloyd, J. C., Fountain, N., Shinnar, S., Lowenstein, D., Conwit, R., Bleck, T. P. & Kapur, J., Dec 2019, In: Epilepsy and Behavior. 101, 106296.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Randomized trial of three anticonvulsant medications for status epilepticus
NETT and PECARN Investigators, Nov 28 2019, In: New England Journal of Medicine. 381, 22, p. 2103-2113 11 p.Research output: Contribution to journal › Article › peer-review
Open Access311 Scopus citations -
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol
For the EpiBioS4Rx Study Group, Mar 2019, In: Neurobiology of Disease. 123, p. 110-114 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access28 Scopus citations -
Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial
Sathe, A. G., Tillman, H., Coles, L. D., Elm, J. J., Silbergleit, R., Chamberlain, J., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Conwit, R. A., Bleck, T. P. & Cloyd, J. C., 2019, In: Academic Emergency Medicine. 26, 8, p. 940-943 4 p.Research output: Contribution to journal › Letter › peer-review
Open Access36 Scopus citations -
2018
Conversion of a soluble diazepam prodrug to supersaturated diazepam for rapid intranasal delivery: Kinetics and stability
Rautiola, D., Cloyd, J. C. & Siegel, R. A., Nov 10 2018, In: Journal of Controlled Release. 289, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress
Coles, L. D., Tuite, P. J., Öz, G., Mishra, U. R., Kartha, R. V., Sullivan, K. M., Cloyd, J. C. & Terpstra, M., Feb 2018, In: Journal of Clinical Pharmacology. 58, 2, p. 158-167 10 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
Rescue therapies for seizure emergencies: New modes of administration
Maglalang, P. D., Rautiola, D., Siegel, R. A., Fine, J. M., Hanson, L. R., Coles, L. D. & Cloyd, J. C., Oct 2018, In: Epilepsia. 59, p. 207-215 9 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2017
A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics
Schmitz, N. S., Krach, L. E., Coles, L. D., Mishra, U., Agarwal, S. K., Cloyd, J. C. & Kriel, R. L., Aug 2017, In: PM and R. 9, 8, p. 743-750 8 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Regulatory Aspects for Drug Development
Coles, L. D., Klitgaard, H., Kuker, M. & Cloyd, J. C., Jan 1 2017, Models of Seizures and Epilepsy: Second Edition. Elsevier Inc., p. 69-82 14 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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2016
A hierarchical Bayesian approach for combining pharmacokinetic/pharmacodynamic modeling and Phase IIa trial design in orphan drugs: Treating adrenoleukodystrophy with Lorenzo’s oil
Basu, C., Ahmed, M. A., Kartha, R., Brundage, R., Raymond, G. V., Cloyd, J. C. & Carlin, B., Nov 1 2016, In: Journal of Biopharmaceutical Statistics. 26, 6, p. 1025-1039 15 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy
Ahmed, M. A., Kartha, R. V., Brundage, R. C., Cloyd, J., Basu, C., Carlin, B. P., Jones, R. O., Moser, A. B., Fatemi, A. & Raymond, G. V., Jun 1 2016, In: British Journal of Clinical Pharmacology. 81, 6, p. 1058-1066 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
A review of intranasal formulations for the treatment of seizure emergencies
Kapoor, M., Cloyd, J. C. & Siegel, R. A., Sep 10 2016, In: Journal of Controlled Release. 237, p. 147-159 13 p.Research output: Contribution to journal › Review article › peer-review
120 Scopus citations -
Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines
Kapoor, M., Cheryala, N., Rautiola, D., Georg, G. I., Cloyd, J. C. & Siegel, R. A., Aug 1 2016, In: Journal of Pharmaceutical Sciences. 105, 8, p. 2365-2371 7 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Clinical utility of topiramate extended-release capsules (USL255): Bioequivalence of USL255 sprinkled and intact capsule in healthy adults and an in vitro evaluation of sprinkle delivery via enteral feeding tubes
Clark, A. M., Pellock, J. M., Holmay, M., Anders, B. & Cloyd, J., Apr 1 2016, In: Epilepsy and Behavior. 57, p. 105-110 6 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Deconstructing tolerance with clobazam
Gidal, B. E., Wechsler, R. T., Sankar, R., Montouris, G. D., White, H. S., Cloyd, J. C., Kane, M. C., Peng, G., Tworek, D. M., Shen, V. & Isojarvi, J., Oct 25 2016, In: Neurology. 87, 17, p. 1806-1812 7 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Intravenous topiramate: Pharmacokinetics in dogs with naturally occurring epilepsy
Vuu, I., Coles, L. D., Maglalang, P., Leppik, I. E., Worrell, G., Crepeau, D., Mishra, U., Cloyd, J. C. & Patterson, E. E., Dec 5 2016, In: Frontiers in Veterinary Science. 3, DEC, 107.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Pharmacokinetic-pharmacodynamic modeling of intravenous and oral topiramate and its effect on the symbol-digit modalities test in adult healthy volunteers
Lim, C. N., Birnbaum, A. K., Brundage, R. C., Leppik, I. E., Cloyd, J. C., Clark, A. & Marino, S. E., Jun 1 2016, In: Journal of Clinical Pharmacology. 56, 6, p. 714-722 9 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2015
Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy
Tolbert, D., Cloyd, J., Biton, V., Bekersky, I., Walzer, M., Wesche, D., Drummond, R. & Lee, D., Jun 1 2015, In: Epilepsia. 56, 6, p. 915-923 9 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Canine status epilepticus treated with fosphenytoin: A proof of principle study
Patterson, E. E., Leppik, I. E., Coles, L. D., Podell, M., Vite, C. H., Bush, W. & Cloyd, J. C., Jun 1 2015, In: Epilepsia. 56, 6, p. 882-887 6 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Development of benzodiazepines for out-of-hospital management of seizure emergencies
Agarwal, S. K. & Cloyd, J. C., Feb 20 2015, In: Neurology: Clinical Practice. 5, 1, p. 80-85 6 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status
Zhou, J., Coles, L. D., Kartha, R. V., Nash, N., Mishra, U., Lund, T. C. & Cloyd, J. C., Aug 1 2015, In: Journal of Pharmaceutical Sciences. 104, 8, p. 2619-2626 8 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy
Patel, S. I., Birnbaum, A. K., Cloyd, J. C. & Leppik, I. E., Dec 1 2015, In: CNS Drugs. 29, 12, p. 1009-1022 14 p.Research output: Contribution to journal › Review article › peer-review
23 Scopus citations -
Intravenous carbamazepine as short-term replacement therapy for oral carbamazepine in adults with epilepsy: Pooled tolerability results from two open-label trials
Lee, D., Kalu, U., Halford, J. J., Biton, V., Cloyd, J., Klein, P., Bekersky, I., Peng, G., Dheerendra, S. & Tolbert, D., Jun 1 2015, In: Epilepsia. 56, 6, p. 906-914 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations