Research output per year
Research output per year
- 44 results
Search results
-
2023
Correction: Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise (Molecular and Cellular Biochemistry, (2023), 478, 4, (899-926), 10.1007/s11010-022-04558-2)
Trembley, J. H., Kren, B. T., Afzal, M., Scaria, G. A., Klein, M. A. & Ahmed, K., Jul 2023, In: Molecular and cellular biochemistry. 478, 7, p. 1659 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Gross Hematuria and Lower Urinary Tract Symptoms Associated With Military Burn Pits Exposures in US Veterans Deployed to Iraq and Afghanistan
Perveen, M. M., Mayo-Malasky, H. E., Lee-Wong, M. F., Tomaska, J. M., Forsyth, E., Gravely, A., Klein, M. A., Trembley, J. H., Butterick, T. A., Promisloff, R. A., Ginex, P. K., Barach, P. & Szema, A. M., Sep 1 2023, In: Journal of occupational and environmental medicine. 65, 9, p. 740-744 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise
Trembley, J. H., Kren, B. T., Afzal, M., Scaria, G. A., Klein, M. A. & Ahmed, K., Apr 2023, In: Molecular and cellular biochemistry. 478, 4, p. 899-926 28 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
2022
Whole-body inhalation of nano-sized carbon black: a surrogate model of military burn pit exposure
Trembley, J. H., So, S. W., Nixon, J. P., Bowdridge, E. C., Garner, K. L., Griffith, J., Engles, K. J., Batchelor, T. P., Goldsmith, W. T., Tomáška, J. M., Hussain, S., Nurkiewicz, T. R. & Butterick, T. A., Dec 2022, In: BMC Research Notes. 15, 1, 275.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2021
Cx-4945 and sirna-mediated knockdown of ck2 improves cisplatin response in hpv(+) and hpv(-) hnscc cell lines
Trembley, J. H., Li, B., Kren, B. T., Gravely, A. A., Caicedo-Granados, E., Klein, M. A. & Ahmed, K., May 2021, In: Biomedicines. 9, 5, 571.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes
Trembley, J. H., Li, B., Kren, B. T., Peltola, J., Manivel, J., Meyyappan, D., Gravely, A., Klein, M., Ahmed, K. & Caicedo-Granados, E., 2021, In: PeerJ. 9, e12519.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer
Afzal, M., Kren, B. T., Naveed, A. K., Trembley, J. H. & Ahmed, K., Jul 1 2020, In: Molecular and cellular biochemistry. 470, 1-2, p. 131-143 13 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2019
CDK11 loss induces cell cycle dysfunction and death of BRAF and NRAS Melanoma Cells
Ahmed, R. L., Shaughnessy, D. P., Knutson, T. P., Vogel, R. I., Ahmed, K., Kren, B. T. & Trembley, J. H., Jun 2019, In: Pharmaceuticals. 12, 2, 50.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
CK2 pro-survival role in prostate cancer is mediated via maintenance and promotion of androgen receptor and NFκB p65 expression
Trembley, J. H., Kren, B. T., Abedin, M. J., Shaughnessy, D. P., Li, Y., Dehm, S. M. & Ahmed, K., Jun 2019, In: Pharmaceuticals. 12, 2, 89.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: Biomarker evidence of inflammation
Butterick, T. A., Trembley, J. H., Hocum Stone, L. L., Muller, C. J., Rudquist, R. R. & Bach, R. R., Dec 18 2019, In: BMC Research Notes. 12, 1, 816.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Improving Health Care for Veterans With Gulf War Illness
Baldwin, N., Rudquist, R. R., Lava-Parmele, S., Trembley, J. H., Butterick, T. A. & Bach, R. R., May 2019, In: Federal practitioner : for the health care professionals of the VA, DoD, and PHS. 36, 5, p. 212-219 8 p.Research output: Contribution to journal › Article › peer-review
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2017
CK2 molecular targeting-tumor cell-specific delivery of RNAi in various models of cancer
Trembley, J. H., Kren, B. T., Abedin, M. J., Vogel, R. I., Cannon, C. M., Unger, G. M. & Ahmed, K., Feb 21 2017, In: Pharmaceuticals. 10, 1, 25.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats
Cannon, C. M., Trembley, J. H., Kren, B. T., Unger, G. M., Gerard O’Sullivan, M., Cornax, I., Modiano, J. F. & Ahmed, K., Aug 2017, In: American journal of veterinary research. 78, 8, p. 946-955 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer
Cannon, C. M., Trembley, J. H., Kren, B. T., Unger, G. M., O'Sullivan, M. G., Cornax, I., Modiano, J. F. & Ahmed, K., Jun 2017, In: Human Gene Therapy Clinical Development. 28, 2, p. 80-86 7 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2016
CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: Dose and molecular mechanisms of response in xenograft prostate tumors
Ahmed, K., Kren, B. T., Abedin, M. J., Vogel, R. I., Shaughnessy, D. P., Nacusi, L., Korman, V. L., Li, Y., Dehm, S. M., Zimmerman, C. L., Niehans, G. A., Unger, G. M. & Trembley, J. H., 2016, In: Oncotarget. 7, 38, p. 61789-61805 17 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues
Qaiser, F., Trembley, J. H., Sadiq, S., Muhammad, I., Younis, R., Hashmi, S. N., Murtaza, B., Rector, T. S., Naveed, A. K. & Ahmed, K., Sep 1 2016, In: Molecular and cellular biochemistry. 420, 1-2, p. 43-51 9 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways
Afsar, T., Trembley, J. H., Salomon, C., Razak, S., Khan, M. R. & Ahmed, K., Mar 15 2016, In: Scientific reports. 6, 23077.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
2015
CK2: A global regulator of cell death
Trembley, J. H., Qaiser, F., Kren, B. T. & Ahmed, K., Jan 1 2015, Protein Kinase CK2 Cellular Function in Normal and Disease States. Springer International Publishing, p. 159-181 23 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy
Kren, B. T., Unger, G. M., Abedin, M. J., Vogel, R. I., Henzler, C. M., Ahmed, K. & Trembley, J. H., Feb 11 2015, In: Breast Cancer Research. 17, 1, 19.Research output: Contribution to journal › Article › peer-review
49 Scopus citations -
Targeting CK2 for cancer therapy using a nanomedicine approach
Ahmed, K., Unger, G., Kren, B. T. & Trembley, J. H., Jan 1 2015, Protein Kinase CK2 Cellular Function in Normal and Disease States. Springer International Publishing, p. 299-315 17 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
7 Scopus citations -
2014
Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma
Unger, G. M., Kren, B. T., Korman, V. L., Kimbrough, T. G., Vogel, R. I., Ondrey, F. G., Trembley, J. H. & Ahmed, K., Aug 2014, In: Molecular Cancer Therapeutics. 13, 8, p. 2018-2029 12 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function
Qaiser, F., Trembley, J. H., Kren, B. T., Wu, J. J., Naveed, A. K. & Ahmed, K., Dec 1 2014, In: Journal of Cellular Biochemistry. 115, 12, p. 2103-2115 13 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Tenfibgen-DMAT nanocapsule delivers CK2 inhibitor DMAT to prostate cancer xenograft tumors causing inhibition of cell proliferation
Trembley, J. H., Unger, G. M., Gomez, O. C., Abedin, M. J., Korman, V. L., Vogel, R. I., Niehans, G., Kren, B. T. & Ahmed, K., 2014, In: Molecular and Cellular Pharmacology. 6, 2, p. 15-25 11 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate Cancer targeting using human xenograft tumors in mice
Trembley, J. H., Unger, G. M., Korman, V. L., Abedin, M. J., Nacusi, L. P., Vogel, R. I., Slaton, J. W., Kren, B. T. & Ahmed, K., Oct 15 2014, In: PloS one. 9, 10, e109970.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
2013
CK2 Suppression of Apoptosis and Its Implication in Cancer Biology and Therapy
Trembley, J. H., Wu, J. J., Unger, G. M., Kren, B. T. & Ahmed, K., Mar 5 2013, Protein Kinase CK2. John Wiley and Sons, p. 319-343 25 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
13 Scopus citations -
2012
Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells
Trembley, J. H., Unger, G. M., Korman, V. L., Tobolt, D. K., Kazimierczuk, Z., Pinna, L. A., Kren, B. T. & Ahmed, K., Feb 1 2012, In: Cancer Letters. 315, 1, p. 48-58 11 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2011
Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice
Trembley, J. H., Unger, G. M., Tobolt, D. K., Korman, V. L., Wang, G., Ahmad, K. A., Slaton, J. W., Kren, B. T. & Ahmed, K., Oct 2011, In: Molecular and cellular biochemistry. 356, 1-2, p. 21-35 15 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
The RNA binding motif protein 15B (RBM15B/OTT3) is a functional competitor of serine-arginine (SR) proteins and antagonizes the positive effect of the CDK11p110-cyclin L2α complex on splicing
Loyer, P., Busson, A., Trembley, J. H., Hyle, J., Grenet, J., Zhao, W., Ribault, C., Montier, T., Kidd, V. J. & Lahti, J. M., Jan 7 2011, In: Journal of Biological Chemistry. 286, 1, p. 147-159 13 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
2010
Emergence of protein kinase CK2 as a key target in cancer therapy
Trembley, J. H., Chen, Z., Unger, G., Slaton, J., Kren, B. T., Van Waes, C. & Ahmed, K., May 2010, In: BioFactors. 36, 3, p. 187-195 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access174 Scopus citations -
2009
CK2: A key player in cancer biology
Trembley, J. H., Wang, G., Unger, G., Slaton, J. & Ahmed, K., Jun 2009, In: Cellular and Molecular Life Sciences. 66, 11-12, p. 1858-1867 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access279 Scopus citations -
2008
Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: Influence of cyclin l isoforms on splice site selection
Loyer, P., Trembley, J. H., Grenet, J. A., Busson, A., Corlu, A., Zhao, W., Kocak, M., Kidd, V. J. & Lahti, J. M., Mar 21 2008, In: Journal of Biological Chemistry. 283, 12, p. 7721-7732 12 p.Research output: Contribution to journal › Article › peer-review
99 Scopus citations -
2005
Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation
Trembley, J. H., Tatsumi, S., Sakashita, E., Loyer, P., Slaughter, C. A., Suzuki, H., Endo, H., Kidd, V. J. & Mayeda, A., Feb 2005, In: Molecular and cellular biology. 25, 4, p. 1446-1457 12 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Role of CDK/cyclin complexes in transcription and RNA splicing
Loyer, P., Trembley, J. H., Katona, R., Kidd, V. J. & Lahti, J. M., Sep 2005, In: Cellular Signalling. 17, 9, p. 1033-1051 19 p.Research output: Contribution to journal › Review article › peer-review
145 Scopus citations -
2004
Cyclin Dependent Kinase 11 in RNA Transcription and Splicing
Trembley, J. H., Loyer, P., Hu, D., Li, T., Grenet, J., Lahti, J. M. & Kidd, V. J., 2004, Progress in Nucleic Acid Research and Molecular Biology. Academic Press Inc., p. 263-288 26 p. (Progress in Nucleic Acid Research and Molecular Biology; vol. 77).Research output: Chapter in Book/Report/Conference proceeding › Chapter
38 Scopus citations -
2003
Casein kinase 2 interacts with cyclin-dependent kinase 11 (CDK11) in vivo and phosphorylates both the rna polymerase II carboxyl-terminal domain and CDk11 in vitro
Trembley, J. H., Hu, D., Slaughter, C. A., Lahti, J. M. & Kidd, V. J., Jan 24 2003, In: Journal of Biological Chemistry. 278, 4, p. 2265-2270 6 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
CDK11 complexes promote pre-mRNA splicing
Hu, D., Mayeda, A., Trembley, J. H., Lahti, J. M. & Kidd, V. J., Mar 7 2003, In: Journal of Biological Chemistry. 278, 10, p. 8623-8629 7 p.Research output: Contribution to journal › Article › peer-review
118 Scopus citations -
2002
PITSLRE p110 protein kinases associate with transcription complexes and affect their activity
Trembley, J. H., Hu, D., Hsu, L. C., Yeung, C. Y., Slaughter, C., Lahti, J. M. & Kidd, V. J., Jan 25 2002, In: Journal of Biological Chemistry. 277, 4, p. 2589-2596 8 p.Research output: Contribution to journal › Article › peer-review
71 Scopus citations -
2000
Genomic organization and promoter characterization of the rat cyclin B1 gene
Trembley, J. H., Chen, Z., Rodrigues, C. M. P., Kren, B. T. & Steer, C. J., Sep 5 2000, In: Gene. 255, 1, p. 93-104 12 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
1998
The RNP protein, RNPS1, associates with specific isoforms of the p34(cdc2)-related PITSLRE protein kinase in vivo
Loyer, P., Trembley, J. H., Lahti, J. M. & Kidd, V. J., 1998, In: Journal of cell science. 111, 11, p. 1495-1506 12 p.Research output: Contribution to journal › Article › peer-review
81 Scopus citations -
1997
Molecular regulation of liver regeneration
Kren, B. T., Trembley, J. H., Fan, G. & Steer, C. J., Dec 31 1997, In: Annals of the New York Academy of Sciences. 831, p. 361-381 21 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
1996
Alterations in mRNA stability during rat liver regeneration
Keen, B. T., Trembley, J. H. & Steer, C. J., 1996, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 270, 5 33-5, p. G763-G777Research output: Contribution to journal › Article › peer-review
55 Scopus citations -
Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo
Trembley, J. H., Ebbert, J. O., Kren, B. T. & Steer, C. J., 1996, In: Cell Growth and Differentiation. 7, 7, p. 903-916 14 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration
Kren, B. T., Trembley, J. H., Krajewski, S., Behrens, T. W., Reed, J. C. & Steer, C. J., 1996, In: Cell Growth and Differentiation. 7, 12, p. 1633-1642 10 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
1994
Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver
Trembley, J. H., Kren, B. T. & Steer, C. J., 1994, In: Cell Growth and Differentiation. 5, 1, p. 99-108 10 p.Research output: Contribution to journal › Article › peer-review
52 Scopus citations