Research output per year
Research output per year
- 1 - 50 out of 56 results
Search results
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2024
Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation
He, Y. L., Collado, J. T., Iuliano, J. N., Woroniecka, H. A., Hall, C. R., Gil, A. A., Laptenok, S. P., Greetham, G. M., Illarionov, B., Bacher, A., Fischer, M., French, J. B., Lukacs, A., Meech, S. R. & Tonge, P. J., Mar 15 2024, In: ACS Chemical Biology. 19, 3, p. 696-706 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins
Aziz, F., Reddy, K., Fernandez Vega, V., Dey, R., Hicks, K. A., Rao, S., Jordan, L. O., Smith, E., Shumate, J., Scampavia, L., Carpino, N., Spicer, T. P. & French, J. B., Feb 8 2024, In: Journal of medicinal chemistry. 67, 3, p. 1949-1960 12 p.Research output: Contribution to journal › Article › peer-review
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2023
Characterization of an Acinetobacter baumannii Monofunctional Phosphomethylpyrimidine Kinase That Is Inhibited by Pyridoxal Phosphate
De Vitto, H., Belfon, K. K. J., Sharma, N., Toay, S., Abendroth, J., Dranow, D. M., Lukacs, C. M., Choi, R., Udell, H. S., Willis, S., Barrera, G., Beyer, O., Li, T. D., Hicks, K. A., Torelli, A. T. & French, J. B., 2023, (Accepted/In press) In: Biochemistry.Research output: Contribution to journal › Article › peer-review
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Cryo-EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms
Le, L. T. M., Thompson, J. R., Dehghani-Ghahnaviyeh, S., Pant, S., Dang, P. X., French, J. B., Kanikeyo, T., Tajkhorshid, E. & Alam, A., Feb 1 2023, In: EMBO Journal. 42, 3, e111065.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Human uridine 5′-monophosphate synthase stores metabolic potential in inactive biomolecular condensates
Kim-Holzapfel, D. M., Dey, R., Richardson, B. C., Arachchige, D., Reddy, K., De Vitto, H., Bhandari, J. & French, J. B., Mar 2023, In: Journal of Biological Chemistry. 299, 3, 102949.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure-Guided Discovery of N5-CAIR Mutase Inhibitors
Belfon, K. K. J., Sharma, N., Zigweid, R., Bolejack, M., Davies, D., Edwards, T. E., Myler, P. J. & French, J. B., Sep 5 2023, In: Biochemistry. 62, 17, p. 2587-2596 10 p.Research output: Contribution to journal › Article › peer-review
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The Sts Proteins: Modulators of Host Immunity
Zaman, A., French, J. B. & Carpino, N., May 2023, In: International journal of molecular sciences. 24, 10, 8834.Research output: Contribution to journal › Review article › peer-review
Open Access -
2022
Structure of Klebsiella pneumoniae adenosine monophosphate nucleosidase
Richardson, B. C., Shek, R., Van Voorhis, W. C. & French, J. B., Oct 2022, In: PloS one. 17, 10 October, e0275023.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2021
Structure of the e. coli agmatinase, speb
Chitrakar, I., Ahmed, S. F., Torelli, A. T. & French, J. B., Apr 2021, In: PloS one. 16, 4 April, e0248991.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
The intersection of purine and mitochondrial metabolism in cancer
De Vitto, H., Arachchige, D. B., Richardson, B. C. & French, J. B., Oct 2021, In: Cells. 10, 10, 2603.Research output: Contribution to journal › Review article › peer-review
Open Access28 Scopus citations -
2020
An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling
Yin, Y., Frank, D., Zhou, W., Kaur, N., French, J. B. & Carpino, N., Jun 19 2020, In: Journal of Biological Chemistry. 295, 25, p. 8514-8523 10 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein
Iuliano, J. N., Hall, C. R., Green, D., Jones, G. A., Lukacs, A., Illarionov, B., Bacher, A., Fischer, M., French, J. B., Tonge, P. J. & Meech, S. R., Aug 20 2020, In: Journal of Physical Chemistry B. 124, 33, p. 7152-7165 14 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Structural Basis for the Regulation of Biofilm Formation and Iron Uptake in A. baumannii by the Blue-Light-Using Photoreceptor, BlsA
Chitrakar, I., Iuliano, J. N., He, Y. L., Woroniecka, H. A., Tolentino Collado, J., Wint, J. M., Walker, S. G., Tonge, P. J. & French, J. B., Oct 9 2020, In: ACS Infectious Diseases. 6, 10, p. 2592-2603 12 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix
Iuliano, J. N., Collado, J. T., Gil, A. A., Ravindran, P. T., Lukacs, A., Shin, S., Woroniecka, H. A., Adamczyk, K., Aramini, J. M., Edupuganti, U. R., Hall, C. R., Greetham, G. M., Sazanovich, I. V., Clark, I. P., Daryaee, T., Toettcher, J. E., French, J. B., Gardner, K. H., Simmerling, C. L., Meech, S. R., & 1 others, Oct 16 2020, In: ACS Chemical Biology. 15, 10, p. 2752-2765 14 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
2019
Crystal structure of E. coli PRPP synthetase
Zhou, W., Tsai, A., Dattmore, D. A., Stives, D. P., Chitrakar, I., D'Alessandro, A. M., Patil, S., Hicks, K. A. & French, J. B., Jan 15 2019, In: BMC Structural Biology. 19, 1, 1.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Depth-extended, high-resolution fluorescence microscopy: Whole-cell imaging with double-ring phase (DRIP) modulation
Hua, X., Guo, C., Wang, J., Kim-Holzapfel, D., Schroeder, B., Liu, W., Yuan, J., French, J. & Jia, S., 2019, In: Biomedical Optics Express. 10, 1, p. 204-214 11 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins
Zhou, W., Yin, Y., Smith, E., Chou, J., Shumate, J., Scampavia, L., Spicer, T. P., Carpino, N. & French, J. B., Feb 8 2019, In: ACS Infectious Diseases. 5, 2, p. 250-259 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Fast, volumetric live-cell imaging using high-resolution light-field microscopy
Li, H., Guo, C., Kim-Holzapfel, D., Li, W., Altshuller, Y., Schroeder, B., Liu, W., Meng, Y., French, J. B., Takamaru, K. I., Frohman, M. A. & Jia, S., 2019, In: Biomedical Optics Express. 10, 1, p. 29-49 21 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily
Shek, R., Hilaire, T., Sim, J. & French, J. B., Jul 30 2019, In: Biochemistry. 58, 30, p. 3280-3292 13 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE
Evans, C. E., Si, Y., Matarlo, J. S., Yin, Y., French, J. B., Tonge, P. J. & Tan, D. S., Apr 9 2019, In: Biochemistry. 58, 14, p. 1918-1930 13 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Vibrational spectroscopy of flavoproteins
Iuliano, J. N., French, J. B. & Tonge, P. J., 2019, New Approaches for Flavin Catalysis. Palfey, B. A. (ed.). Academic Press Inc., p. 189-214 26 p. (Methods in Enzymology; vol. 620).Research output: Chapter in Book/Report/Conference proceeding › Chapter
9 Scopus citations -
2018
Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy
Iuliano, J. N., Gil, A. A., Laptenok, S. P., Hall, C. R., Tolentino Collado, J., Lukacs, A., Hag Ahmed, S. A., Abyad, J., Daryaee, T., Greetham, G. M., Sazanovich, I. V., Illarionov, B., Bacher, A., Fischer, M., Towrie, M., French, J. B., Meech, S. R. & Tonge, P. J., Feb 6 2018, In: Biochemistry. 57, 5, p. 620-630 11 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice
Van Skike, N. D., Minkah, N. K., Hogan, C. H., Wu, G., Benziger, P. T., Oldenburg, D. G., Kara, M., Kim-Holzapfel, D. M., White, D. W., Tibbetts, S. A., French, J. B. & Krug, L. T., Feb 2018, In: PLoS pathogens. 14, 2, e1006843.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2017
Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain
Gil, A. A., Laptenok, S. P., French, J. B., Iuliano, J. N., Lukacs, A., Hall, C. R., Sazanovich, I. V., Greetham, G. M., Bacher, A., Illarionov, B., Fischer, M., Tonge, P. J. & Meech, S. R., Feb 9 2017, In: Journal of Physical Chemistry B. 121, 5, p. 1010-1019 10 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Higher order structures in purine and pyrimidine metabolism
Chitrakar, I., Kim-Holzapfel, D. M., Zhou, W. & French, J. B., Mar 1 2017, In: Journal of Structural Biology. 197, 3, p. 354-364 11 p.Research output: Contribution to journal › Review article › peer-review
30 Scopus citations -
Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues
Gil, A. A., Laptenok, S. P., Iuliano, J. N., Lukacs, A., Verma, A., Hall, C. R., Yoon, G. E., Brust, R., Greetham, G. M., Towrie, M., French, J. B., Meech, S. R. & Tonge, P. J., Oct 18 2017, In: Journal of the American Chemical Society. 139, 41, p. 14638-14648 11 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Structural and Functional Basis for Targeting Campylobacter jejuni Agmatine Deiminase to Overcome Antibiotic Resistance
Shek, R., Dattmore, D. A., Stives, D. P., Jackson, A. L., Chatfield, C. H., Hicks, K. A. & French, J. B., Dec 26 2017, In: Biochemistry. 56, 51, p. 6734-6742 9 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2
Zhou, W., Yin, Y., Weinheimer, A. S., Kaur, N., Carpino, N. & French, J. B., Sep 5 2017, In: Biochemistry. 56, 35, p. 4637-4645 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2016
Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: Effect of the Y21 pKa on the Forward and Reverse Ground-State Reactions
Gil, A. A., Haigney, A., Laptenok, S. P., Brust, R., Lukacs, A., Iuliano, J. N., Jeng, J., Melief, E. H., Zhao, R. K., Yoon, E. B., Clark, I. P., Towrie, M., Greetham, G. M., Ng, A., Truglio, J. J., French, J. B., Meech, S. R. & Tonge, P. J., Jan 27 2016, In: Journal of the American Chemical Society. 138, 3, p. 926-935 10 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Spatial colocalization and functional link of purinosomes with mitochondria
French, J. B., Jones, S. A., Deng, H., Pedley, A. M., Kim, D., Chan, C. Y., Hu, H., Pugh, R. J., Zhao, H., Zhang, Y., Huang, T. J., Fang, Y., Zhuang, X. & Benkovic, S. J., Feb 12 2016, In: Science. 351, 6274, p. 733-737 5 p.Research output: Contribution to journal › Article › peer-review
Open Access149 Scopus citations -
2015
Controlling cell-cell interactions using surface acoustic waves
Guo, F., Li, P., French, J. B., Mao, Z., Zhao, H., Li, S., Nama, N., Fick, J. R., Benkovic, S. J. & Huang, T. J., Jan 6 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 1, p. 43-48 6 p.Research output: Contribution to journal › Article › peer-review
Open Access314 Scopus citations -
Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents
Matarlo, J. S., Evans, C. E., Sharma, I., Lavaud, L. J., Ngo, S. C., Shek, R., Rajashankar, K. R., French, J. B., Tan, D. S. & Tonge, P. J., Oct 27 2015, In: Biochemistry. 54, 42, p. 6514-6524 11 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves
Guo, F., Zhou, W., Li, P., Mao, Z., Yennawar, N. H., French, J. B. & Huang, T. J., Jun 1 2015, In: Small. 11, 23, p. 2733-2737 5 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Purinosome formation as a function of the cell cycle
Chan, C. Y., Zhao, H., Pugh, R. J., Pedley, A. M., French, J., Jones, S. A., Zhuang, X., Jinnah, H., Huan, T. J. & Benkovic, S. J., Feb 3 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1368-1373 6 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
Quantitative analysis of purine nucleotides indicates that purinosomes increase de Novo purine biosynthesis
Zhao, H., Chiaro, C. R., Zhang, L., Smith, P. B., Chan, C. Y., Pedley, A. M., Pugh, R. J., French, J. B., Patterson, A. D. & Benkovic, S. J., Mar 13 2015, In: Journal of Biological Chemistry. 290, 11, p. 6705-6713 9 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
2014
Acoustofluidic chemical waveform generator and switch
Ahmed, D., Muddana, H. S., Lu, M., French, J. B., Ozcelik, A., Fang, Y., Butler, P. J., Benkovic, S. J., Manz, A. & Huang, T. J., Dec 2 2014, In: Analytical Chemistry. 86, 23, p. 11803-11810 8 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Probing the electrostatics of active site microenvironments along the catalytic cycle for escherichia coli dihydrofolate reductase
Liu, C. T., Layfield, J. P., Stewart, R. J., French, J. B., Hanoian, P., Asbury, J. B., Hammes-Schiffer, S. & Benkovic, S. J., Jul 23 2014, In: Journal of the American Chemical Society. 136, 29, p. 10349-10360 12 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations -
2013
Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans
Liu, C. T., Hanoian, P., French, J. B., Pringle, T. H., Hammes-Schiffer, S. & Benkovic, S. J., Jun 18 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 25, p. 10159-10164 6 p.Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
G-protein-coupled receptor regulation of de novo purine biosynthesis: A novel druggable mechanism
Fang, Y., French, J., Zhao, H. & Benkovic, S., 2013, In: Biotechnology and Genetic Engineering Reviews. 29, 1, p. 31-48 18 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome
French, J. B., Zhao, H., An, S., Niessen, S., Deng, Y., Cravatt, B. F. & Benkovic, S. J., Feb 12 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 7, p. 2528-2533 6 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Lab-on-a-chip technologies for single-molecule studies
Zhao, Y., Chen, D., Yue, H., French, J. B., Rufo, J., Benkovic, S. J. & Huang, T. J., Jun 21 2013, In: Lab on a chip. 13, 12, p. 2183-2198 16 p.Research output: Contribution to journal › Review article › peer-review
47 Scopus citations -
Probing cell-cell communication with microfluidic devices
Guo, F., French, J. B., Li, P., Zhao, H., Chan, C. Y., Fick, J. R., Benkovic, S. J. & Huang, T. J., Aug 21 2013, In: Lab on a chip. 13, 16, p. 3152-3162 11 p.Research output: Contribution to journal › Review article › peer-review
61 Scopus citations -
The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans
French, J. B., Fang, Y. & Benkovic, S. J., Apr 23 2013, In: Chemical Communications. 49, 40, p. 4444-4452 9 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
2012
Mapping protein-protein proximity in the purinosome
Deng, Y., Gam, J., French, J. B., Zhao, H., An, S. & Benkovic, S. J., Oct 19 2012, In: Journal of Biological Chemistry. 287, 43, p. 36201-36207 7 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
2011
Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase
French, J. B., Neau, D. B. & Ealick, S. E., Jul 15 2011, In: Journal of Molecular Biology. 410, 3, p. 447-460 14 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae
French, J. B. & Ealick, S. E., Aug 2011, In: Acta Crystallographica Section D: Biological Crystallography. 67, 8, p. 671-677 7 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Structure of trifunctional THI20 from yeast
French, J. B., Begley, T. P. & Ealick, S. E., Sep 2011, In: Acta Crystallographica Section D: Biological Crystallography. 67, 9, p. 784-791 8 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization
French, J. B., Yates, P. A., Soysa, D. R., Boitz, J. M., Carter, N. S., Chang, B., Ullman, B. & Ealick, S. E., Jun 10 2011, In: Journal of Biological Chemistry. 286, 23, p. 20930-20941 12 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
2010
Biochemical and structural characterization of a ureidoglycine aminotransferase in the klebsiella pneumoniae uric acid catabolic pathway
French, J. B. & Ealick, S. E., Jul 27 2010, In: Biochemistry. 49, 29, p. 5975-5977 3 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Characterization of nicotinamidases: Steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism
French, J. B., Cen, Y., Vrablik, T. L., Xu, P., Allen, E., Hanna-Rose, W. & Sauve, A. A., Dec 14 2010, In: Biochemistry. 49, 49, p. 10421-10439 19 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations