Joanne L Billings

2024

Assessing Safety of Discontinuing Hypertonic Saline in Those with Lower Forced Expiratory Volume in 1 Second after Elexacaftor/Tezacaftor/Ivacaftor

Nichols, D., Gifford, A., Russell, R., Odem-Davis, K., Young, J., Amaro-Galvez, R., Billings, J., Mukadam, Z. & Mayer-Hamblett, N., Feb 1 2024, In: Annals of the American Thoracic Society. 21, 2, p. 360-362 3 p.

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Immunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials

CORIMUNO-19 Collaborative Group, DisCoVeRy Study Group, ACTT-2 Study Group & ACTT-3 Study Group, Mar 2024, In: EClinicalMedicine. 69, 102472.

Research output: Contribution to journal › Article › peer-review

Open Access

Seroprevalence of SARS-CoV-2 IgG in people with cystic fibrosis

Mahan, K., Kiel, S., Freese, R., Marka, N. A., Dunitz, J. & Billings, J., Mar 30 2024, In: Heliyon. 10, 6, e27567.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Clinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals With Smoking Exposure: A Longitudinal Follow-up Study of the COPDGene Cohort

COPDGene Investigators, Feb 2023, In: CHEST. 163, 2, p. 292-302 11 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials

SIMPLIFY Study Group, Apr 2023, In: The Lancet Respiratory Medicine. 11, 4, p. 329-340 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease

COPDGene® Investigators – Core Units & COPDGene® Investigators – Clinical Centers, Mar 2023, In: Respiratory Medicine. 208, 107126.

Research output: Contribution to journal › Article › peer-review

Risk of COVID-19 after natural infection or vaccination

the NIAID-funded COVID-19 Prevention Network (CoVPN), Oct 2023, In: EBioMedicine. 96, 104799.

Research output: Contribution to journal › Article › peer-review

Open Access

Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials

VX18-121-101 & VX18-561-101 Study Groups, Jun 2023, In: The Lancet Respiratory Medicine. 11, 6, p. 550-562 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Sexual and reproductive health experiences and care of adult women with cystic fibrosis

Kazmerski, T. M., Stransky, O. M., Lavage, D. R., Taylor-Cousar, J. L., Sawicki, G. S., Ladores, S. L., Godfrey, E. M., Aitken, M. L., Fields, A., Sufian, S., Jain, M., Barto, T. L., Billings, J., Hadjiliadis, D. & Jain, R., Mar 2023, In: Journal of Cystic Fibrosis. 22, 2, p. 223-233 11 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2022

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial

ACTT-4 Study Group, Sep 2022, In: The Lancet Respiratory Medicine. 10, 9, p. 888-899 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Clinically Significant and Comorbid Anxiety and Depression Symptoms Predict Severe Respiratory Exacerbations in Smokers: A Post Hoc Analysis of the COPDGene and SPIROMICS Cohorts

On behalf of the COPDGene and SPIROMICS Investigators, Jan 2022, In: Annals of the American Thoracic Society. 19, 1, p. 143-146 4 p.

Research output: Contribution to journal › Letter › peer-review

6 Scopus citations

Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2022, In: Respiratory research. 23, 1, 97.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study

Abdelwahab, N., Ingraham, N. E., Nguyen, N., Siegel, L., Silverman, G., Sahoo, H. S., Pakhomov, S., Morse, L. R., Billings, J., Usher, M. G., Melnik, T. E., Tignanelli, C. J. & Ikramuddin, F., Oct 2022, In: Archives of Physical Medicine and Rehabilitation. 103, 10, p. 2001-2008 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trial

TEACH Study Group, Jun 2022, In: Thorax. 77, 6, p. 581-588 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2021

Baricitinib plus remdesivir for hospitalized adults with Covid-19

ACTT-2 Study Group Members, Mar 4 2021, In: New England Journal of Medicine. 384, 9, p. 795-807 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1211 Scopus citations

Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial

ACTT-3 study group members, Dec 2021, In: The Lancet Respiratory Medicine. 9, 12, p. 1365-1376 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort

COPDGene Investigators, Oct 1 2021, In: CHEST. 160, 4, p. 1245-1254 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial

Thiede, J. M., Gress, A. R., Libby, S. D., Ronayne, C. E., Matchett, W. E., Noren, B., Billings, J. L., Menachery, V. D., Langlois, R. A., Kline, S. & Bold, T. D., Apr 15 2021, In: Journal of Infectious Diseases. 223, 8, p. 1339-1344 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Long-term safety and efficacy of tezacaftor–ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study

VX14-661-110 study group, Jul 2021, In: The Lancet Respiratory Medicine. 9, 7, p. 733-746 14 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Lumacaftor/ivacaftor therapy fails to increase insulin secretion in F508del/F508del CF patients

PROSPECT Investigators of the Cystic Fibrosis Foundation Therapeutics Development Network, Mar 2021, In: Journal of Cystic Fibrosis. 20, 2, p. 333-338 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Mucus plugging on computed tomography and chronic bronchitis in chronic obstructive pulmonary disease

The COPDGene Investigators, Dec 1 2021, In: Respiratory research. 22, 1, 110.

Research output: Contribution to journal › Letter › peer-review

Open Access

8 Scopus citations

Multi-dimensional clinical phenotyping of a national cohort of adult cystic fibrosis patients

Conrad, D. J., Billings, J., Teneback, C., Koff, J., Rosenbluth, D., Bailey, B. A. & Jain, R., Jan 2021, In: Journal of Cystic Fibrosis. 20, 1, p. 91-96 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: The Genetic Epidemiology of COPD Study

COPDGene Investigators, Aug 1 2021, In: CHEST. 160, 2, p. 470-480 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

The Association Between Lung Hyperinflation and Coronary Artery Disease in Smokers

COPDGene Investigators, Sep 1 2021, In: CHEST. 160, 3, p. 858-871 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2020

Disease progression modeling in chronic obstructive pulmonary disease

Young, A. L., Bragman, F. J. S., Rangelov, B., Han, M. K., Galbán, C. J., Lynch, D. A., Hawkes, D. J., Alexander, D. C., Hurst, J. R., Crapo, J. D., Silverman, E. K., Make, B. J., Regan, E. A., Beaty, T., Begum, F., Castaldi, P. J., Cho, M., DeMeo, D. L., Boueiz, A. R., Foreman, M. G., & 159 othersHalper-Stromberg, E., Hayden, L. P., Hersh, C. P., Hetmanski, J., Hobbs, B. D., Hokanson, J. E., Laird, N., Lange, C., Lutz, S. M., McDonald, M. L., Parker, M. M., Qiao, D., Regan, E. A., Silverman, E. K., Wan, E. S., Won, S., Sakornsakolpat, P., Prokopenko, D., Qaisi, M. A., Coxson, H. O., Gray, T., Hoffman, E. A., Humphries, S., Jacobson, F. L., Judy, P. F., Kazerooni, E. A., Kluiber, A., Lynch, D. A., Newell, J. D., Regan, E. A., Ross, J. C., Estepar, R. S. J., Schroeder, J., Sieren, J., Stinson, D., Stoel, B. C., Tschirren, J., Van Beek, E., Van Ginneken, B., Van Rikxoort, E., Washko, G., Wilson, C. G., Jensen, R., Everett, D., Crooks, J., Moore, C., Strand, M., Wilson, C. G., Hokanson, J. E., Hughes, J., Kinney, G., Lutz, S. M., Pratte, K., Young, K. A., Bhatt, S., Bon, J., Make, B. J., Martinez, C., Murray, S., Regan, E. A., Soler, X., Wilson, C. G., Bowler, R. P., Kechris, K., Banaei-Kashani, F., Curtis, J. L., Martinez, C. H., Pernicano, P. G., Hanania, N., Alapat, P., Atik, M., Bandi, V., Boriek, A., Guntupalli, K., Guy, E., Nachiappan, A., Parulekar, A., DeMeo, D. L., Jacobson, F. L., Barr, R. G., Austin, J., D'Souza, B., Pearson, G. D. N., Rozenshtein, A., Thomashow, B., MacIntyre, N., McAdams, H. P., Washington, L., McEvoy, C., Tashjian, J., Wise, R., Brown, R., Hansel, N. N., Horton, K., Lambert, A., Putcha, N., Casaburi, R., Adami, A., Budoff, M., Fischer, H., Porszasz, J., Rossiter, H., Stringer, W., Sharafkhaneh, A., Lan, C., Wendt, C., Bell, B., Foreman, M. G., Berkowitz, E., Westney, G., Bowler, R. P., Lynch, D. A., Rosiello, R., Pace, D., Criner, G., Ciccolella, D., Cordova, F., Dass, C., D'Alonzo, G., Desai, P., Jacobs, M., Kelsen, S., Kim, V., Mamary, A. J., Marchetti, N., Satti, A., Shenoy, K., Steiner, R. M., Swift, A., Swift, I., Vega-Sanchez, M. E., Dransfield, M., Bailey, W., Bhatt, S., Iyer, A., Nath, H., Wells, J. M., Ramsdell, J., Friedman, P., Soler, X., Yen, A., Comellas, A. P., Hoth, K. F., Newell, J. D., Thompson, B., Kazerooni, E. A., Martinez, C. H., Billings, J., Begnaud, A., Allen, T., Sciurba, F., Bon, J., Chandra, D., Fuhrman, C., Weissfeld, J., Anzueto, A., Adams, S., Maselli-Caceres, D. & Ruiz, M. E., Feb 1 2020, In: American journal of respiratory and critical care medicine. 201, 3, p. 294-302 9 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Immunoglobulin E as a biomarker for the overlap of atopic asthma and chronic obstructive pulmonary disease

COPDGene® Investigators, 2020, In: Chronic Obstructive Pulmonary Diseases. 7, 1, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Remdesivir for the treatment of COVID-19 — Final report

ACTT-1 Study Group Members, Essential Regulatory Documents Group Team (ERDG Team), DMID CROMS Study Information Office Team (SIO Team), Safety Oversight Committee Support Team (SOCS Team) & DMID CROMS Teleconferencing Team, Nov 5 2020, In: New England Journal of Medicine. 383, 19, p. 1813-1826 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4967 Scopus citations

2019

The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition

COPDGene Investigators, Oct 2019, In: CHEST. 156, 4, p. 685-695 11 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2018

Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease

COPDGene and ECLIPSE Investigators, Jun 1 2018, In: Journal of Allergy and Clinical Immunology. 141, 6, p. 2037-2047.e10

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression

COPDGene Investigators & COPDGene Investigators, Jan 2018, In: CHEST. 153, 1, p. 65-76 12 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Longitudinal phenotypes and mortality in preserved ratio impaired spirometry in the COPDGene study

for the COPDGene Investigators, Dec 1 2018, In: American journal of respiratory and critical care medicine. 198, 11, p. 1397-1405 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

2017

Sex-based genetic association study identifies celsr1 as a possible chronic obstructive pulmonary disease risk locus among women

the COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators, Mar 1 2017, In: American journal of respiratory cell and molecular biology. 56, 3, p. 332-341 10 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2016

Colonoscopic screening shows increased early incidence and progression of adenomas in cystic fibrosis

Niccum, D. E., Billings, J. L., Dunitz, J. M. & Khoruts, A., Jul 1 2016, In: Journal of Cystic Fibrosis. 15, 4, p. 548-553 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

Sun, W., Kechris, K., Jacobson, S., Drummond, M. B., Hawkins, G. A., Yang, J., Chen, T. H., Quibrera, P. M., Anderson, W., Barr, R. G., Basta, P. V., Bleecker, E. R., Beaty, T., Casaburi, R., Castaldi, P., Cho, M. H., Comellas, A., Crapo, J. D., Criner, G., Demeo, D., & 32 othersChristenson, S. A., Couper, D. J., Curtis, J. L., Doerschuk, C. M., Freeman, C. M., Gouskova, N. A., Han, M. L. K., Hanania, N. A., Hansel, N. N., Hersh, C. P., Hoffman, E. A., Kaner, R. J., Kanner, R. E., Kleerup, E. C., Lutz, S., Martinez, F. J., Meyers, D. A., Peters, S. P., Regan, E. A., Rennard, S. I., Scholand, M. B., Silverman, E. K., Woodruff, P. G., O’Neal, W. K., Bowler, R. P., Alexis, N. E., Boucher, R. C., Carretta, E. E., Sciurba, F., Chandra, D., SPIROMICS Research Group & COPDGene Investigators, Aug 2016, In: PLoS genetics. 12, 8, e1006011.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Risk factors for COPD exacerbations in inhaled medication users: The COPDGene study biannual longitudinal follow-up prospective cohort

The COPDGene Investigators, Feb 10 2016, In: BMC Pulmonary Medicine. 16, 1, 28.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The University of Minnesota Donor Lung Quality Index: A Consensus-Based Scoring Application Improves Donor Lung Use

Loor, G., Radosevich, D. M., Kelly, R. F., Cich, I., Grabowski, T. S., Lyon, C., Michael Morrow, J., Bender, E. M., Billings, J. & Hertz, M., Oct 1 2016, In: Annals of Thoracic Surgery. 102, 4, p. 1156-1165 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2015

Clinical and radiologic disease in smokers with normal spirometry

Regan, E. A., Lynch, D. A., Curran-Everett, D., Curtis, J. L., Austin, J. H. M., Grenier, P. A., Kauczor, H. U., Bailey, W. C., De Meo, D. L., Casaburi, R. H., Friedman, P., Van Beek, E. J. R., Hokanson, J. E., Bowler, R. P., Beaty, T. H., Washko, G. R., Han, M. K., Kim, V., Kim, S. S., Yagihashi, K., & 87 othersWashington, L., McEvoy, C. E., Tanner, C., Mannino, D. M., Make, B. J., Silverman, E. K., Crapo, J. D., Martinez, C., Pernicano, P. G., Hanania, N., Alapat, P., Bandi, V., Atik, M., Boriek, A., Guntupalli, K., Guy, E., Parulekar, A., Nachiappan, A., Hersh, C., Jacobson, F., Barr, R. G., Thomashow, B., D'Souza, B., Pearson, G. D. N., Rozenshtein, A., MacIntyre, N., McAdams, H. P., Tashjian, J., Wise, R., Hansel, N., Brown, R., Horton, K., Putcha, N., Adami, A., Porszasz, J., Fischer, H., Budoff, M., Cannon, D., Rossiter, H., Sharafkhaneh, A., Lan, C., Wendt, C., Bell, B., Foreman, M., Westney, G., Berkowitz, E., Rosiello, R., Pace, D., Criner, G., Ciccolella, D., Cordova, F., Dass, C., D'Alonzo, R., Desai, P., Jacobs, M., Kelsen, S., Mamary, A. J., Marchetti, N., Satti, A., Shenoy, K., Steiner, R. M., Swift, A., Swift, I., Vega-Sanchez, G., Dransfield, M., Wells, J. M., Bhatt, S., Nath, H., Ramsdell, J., Soler, X., Yen, A., Cornellas, A., Newell, J., Thompson, B., Kazerooni, E., Martinez, F., Billings, J., Allen, T., Sciurba, F., Chandra, D., Weissfeld, J., Fuhrman, C., Bon, J., Anzueto, A., Adams, S., Maselli-Caceres, D. & Ruiz, M. E., Sep 1 2015, In: JAMA internal medicine. 175, 9, p. 1539-1549 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

347 Scopus citations

2014

Early colon screening of adult patients with cystic fibrosis reveals high incidence of adenomatous colon polyps

Billings, J. L., Dunitz, J. M., McAllister, S., Herzog, T., Bobr, A. & Khoruts, A., Oct 1 2014, In: Journal of clinical gastroenterology. 48, 9, p. e85-e88

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

2013

Insulin secretion improves in cystic fibrosis following ivacaftor correction of CFTR: A small pilot study

Bellin, M. D., Laguna, T., Leschyshyn, J., Regelmann, W., Dunitz, J., Billings, J. & Moran, A., Sep 2013, In: Pediatric Diabetes. 14, 6, p. 417-421 5 p.

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection

Clancy, J. P., Dupont, L., Konstan, M. W., Billings, J., Fustik, S., Goss, C. H., Lymp, J., Minic, P., Quittner, A. L., Rubenstein, R. C., Young, K. R., Saiman, L., Burns, J. L., Govan, J. R. W., Ramsey, B. & Gupta, R., Sep 2013, In: Thorax. 68, 9, p. 818-825 8 p.

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

2011

A pre-post retrospective study of patients with cystic fibrosis and gastrostomy tubes

Best, C., Brearley, A., Gaillard, P., Regelmann, W., Billings, J., Dunitz, J., Phillips, J., Holme, B. & Schwarzenberg, S. J., Oct 2011, In: Journal of pediatric gastroenterology and nutrition. 53, 4, p. 453-458 6 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2010

An international randomized multicenter comparison of nasal potential difference techniques

Solomon, G. M., Konstan, M. W., Wilschanski, M., Billings, J., Sermet-Gaudelus, I., Accurso, F., Vermeulen, F., Levin, E., Hathorne, H., Reeves, G., Sabbatini, G., Hill, A., Mayer-Hamblett, N., Ashlock, M., Clancy, J. P. & Rowe, S. M., Oct 1 2010, In: CHEST. 138, 4, p. 919-928 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Comparison of settings used for high-frequency chest-wall compression in cystic fibrosis

Kempainen, R. R., Milla, C., Dunitz, J. M., Savik, K., Hazelwood, A., Williams, C., Rubin, B. K. & Billings, J. L., 2010, In: Respiratory care. 55, 6, p. 695-701 7 p.

Research output: Contribution to journal › Article › peer-review