Research output per year
Research output per year
- 1 - 50 out of 135 results
Search results
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2023
A year in review: brain barriers and brain fluids research in 2022
Keep, R. F., Jones, H. C., Hamilton, M. G. & Drewes, L. R., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 30.Research output: Contribution to journal › Editorial › peer-review
Open Access2 Scopus citations -
Genetic disorders and genetic manipulation at the blood-brain barriers
Keep, R. F., Jones, H. C. & Drewes, L. R., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 29.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Retirement of Dr. Hazel Jones as Co-Editor-in-Chief of Fluids and Barriers of the CNS. Dr. Mark Hamilton becomes Co-Editor-in-Chief
Keep, R. F. & Drewes, L. R., Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 38.Research output: Contribution to journal › Editorial › peer-review
Open Access -
2022
Advances in brain barriers and brain fluids research in 2021: great progress in a time of adversity
Keep, R. F., Jones, H. C. & Drewes, L. R., Dec 2022, In: Fluids and Barriers of the CNS. 19, 1, 48.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Brain Endothelial Cells: Metabolic Flux and Energy Metabolism
McDonald, C. J., Blankenheim, Z. & Drewes, L. R., 2022, Handbook of Experimental Pharmacology. Springer Science and Business Media Deutschland GmbH, p. 59-79 21 p. (Handbook of Experimental Pharmacology; vol. 273).Research output: Chapter in Book/Report/Conference proceeding › Chapter
4 Scopus citations -
2021
Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood–brain barrier and neurovascular unit
Keep, R. F., Jones, H. C. & Drewes, L. R., Dec 2021, In: Fluids and Barriers of the CNS. 18, 1, 24.Research output: Contribution to journal › Editorial › peer-review
Open Access7 Scopus citations -
2020
Addressing BBB heterogeneity: A new paradigm for drug delivery to brain tumors
Griffith, J. I., Rathi, S., Zhang, W., Zhang, W., Drewes, L. R., Sarkaria, J. N. & Elmquist, W. F., Dec 2020, In: Pharmaceutics. 12, 12, p. 1-38 38 p., 1205.Research output: Contribution to journal › Review article › peer-review
Open Access29 Scopus citations -
A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma
Khammanivong, A., Saha, J., Spartz, A. K., Sorenson, B. S., Bush, A. G., Korpela, D. M., Gopalakrishnan, R., Jonnalagadda, S., Mereddy, V. R., O'Brien, T. D., Drewes, L. R. & Dickerson, E. B., Sep 1 2020, In: Veterinary and Comparative Oncology. 18, 3, p. 324-341 18 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
CNS fluid and solute movement: Physiology, modelling and imaging
Jones, H. C., Keep, R. F. & Drewes, L. R., Feb 4 2020, In: Fluids and Barriers of the CNS. 17, 1, 12.Research output: Contribution to journal › Editorial › peer-review
Open Access7 Scopus citations -
Development of novel analogs of the monocarboxylate transporter ligand FACH and biological validation of one potential radiotracer for positron emission tomography (PET) imaging
Sadeghzadeh, M., Wenzel, B., Gündel, D., Deuther-Conrad, W., Toussaint, M., Moldovan, R. P., Fischer, S., Ludwig, F. A., Teodoro, R., Jonnalagadda, S., Jonnalagadda, S. K., Schüürmann, G., Mereddy, V. R., Drewes, L. R. & Brust, P., May 2020, In: Molecules. 25, 10, 2309.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
This was the year that was: Brain barriers and brain fluid research in 2019
Keep, R. F., Jones, H. C. & Drewes, L. R., Mar 5 2020, In: Fluids and Barriers of the CNS. 17, 1, 20.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2019
Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)
Sadeghzadeh, M., Moldovan, R. P., Fischer, S., Wenzel, B., Ludwig, F. A., Teodoro, R., Deuther-Conrad, W., Jonnalagadda, S., Jonnalagadda, S. K., Gudelis, E., Šačkus, A., Higuchi, K., Ganapathy, V., Mereddy, V. R., Drewes, L. R. & Brust, P., Jun 30 2019, In: Journal of Labelled Compounds and Radiopharmaceuticals. 62, 8, p. 411-424 14 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment
Nelson, G. L., Ronayne, C. T., Solano, L. N., Jonnalagadda, S. K., Jonnalagadda, S., Rumbley, J., Holy, J., Rose-Hellekant, T., Drewes, L. R. & Mereddy, V. R., Dec 1 2019, In: Scientific reports. 9, 1, 18266.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors
Jonnalagadda, S., Jonnalagadda, S. K., Ronayne, C. T., Nelson, G. L., Solano, L. N., Rumbley, J. N., Holy, J. M., Mereddy, V. R. & Drewes, L. R., Mar 22 2019, In: Oncotarget. 10, 24, p. 2355-2368 14 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
The year in review: Progress in brain barriers and brain fluid research in 2018
Keep, R. F., Jones, H. C. & Drewes, L. R., Feb 5 2019, In: Fluids and Barriers of the CNS. 16, 1, 4.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
Vascular dysfunction—The disregarded partner of Alzheimer's disease
Sweeney, M. D., Montagne, A., Sagare, A. P., Nation, D. A., Schneider, L. S., Chui, H. C., Harrington, M. G., Pa, J., Law, M., Wang, D. J. J., Jacobs, R. E., Doubal, F. N., Ramirez, J., Black, S. E., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, P. M., & 49 others, Jan 2019, In: Alzheimer's and Dementia. 15, 1, p. 158-167 10 p.Research output: Contribution to journal › Short survey › peer-review
Open Access428 Scopus citations -
2018
mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction
Liu, D., Stowie, A., de Zavalia, N., Leise, T., Pathak, S. S., Drewes, L. R., Davidson, A. J., Amir, S., Sonenberg, N. & Cao, R., Apr 3 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. E3296-E3304Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol
Netto, J. P., Iliff, J., Stanimirovic, D., Krohn, K. A., Hamilton, B., Varallyay, C., Gahramanov, S., Daldrup-Link, H., D'Esterre, C., Zlokovic, B., Sair, H., Lee, Y., Taheri, S., Jain, R., Panigrahy, A., Reich, D. S., Drewes, L. R., Castillo, M. & Neuwelt, E. A., Jun 1 2018, In: Neurosurgery. 82, 6, p. 770-780 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access35 Scopus citations -
Progress in brain barriers and brain fluid research in 2017
Keep, R. F., Jones, H. C. & Drewes, L. R., Feb 2 2018, In: Fluids and Barriers of the CNS. 15, 1, 6.Research output: Contribution to journal › Editorial › peer-review
Open Access5 Scopus citations -
2017
Brain barriers and brain fluid research in 2016: Advances, challenges and controversies
Keep, R. F., Jones, H. C. & Drewes, L. R., Feb 2 2017, In: Fluids and Barriers of the CNS. 14, 1, 4.Research output: Contribution to journal › Editorial › peer-review
Open Access2 Scopus citations -
Hibernation-based blood loss therapy increases survivability of lethal hemorrhagic shock in rats
Perez de Lara Rodriguez, C. E., Drewes, L. R. & Andrews, M. T., Jul 1 2017, In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 187, 5-6, p. 769-778 10 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2016
Advances in brain barriers and brain fluid research and news from Fluids and Barriers of the CNS
Drewes, L. R., Jones, H. C. & Keep, R. F., Jan 28 2016, In: Fluids and Barriers of the CNS. 13, 1, 1.Research output: Contribution to journal › Editorial › peer-review
Open Access -
A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth
De Feyter, H. M., Behar, K. L., Rao, J. U., Madden-Hennessey, K., Ip, K. L., Hyder, F., Drewes, L. R., Geschwind, J. F., De Graaf, R. A. & Rothman, D. L., Aug 1 2016, In: Neuro-Oncology. 18, 8, p. 1079-1087 9 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents
Gurrapu, S., Jonnalagadda, S. K., Alam, M. A., Ronayne, C. T., Nelson, G. L., Solano, L. N., Lueth, E. A., Drewes, L. R. & Mereddy, V. R., 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 14, p. 3282-3286 5 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Regulation of monocarboxylic acid transporter 1 trafficking by the canonical Wnt/β-catenin pathway in rat brain endothelial cells requires cross-talk with notch signaling
Liu, Z., Sneve, M., Haroldson, T. A., Smith, J. P. & Drewes, L. R., Apr 8 2016, In: Journal of Biological Chemistry. 291, 15, p. 8059-8069 11 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2015
Monocarboxylate transporter 1 inhibitors as potential anticancer agents
Gurrapu, S., Jonnalagadda, S. K., Alam, M. A., Nelson, G. L., Sneve, M. G., Drewes, L. R. & Mereddy, V. R., May 14 2015, In: ACS Medicinal Chemistry Letters. 6, 5, p. 558-561 4 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
2014
Frizzled fissure to improve central nervous system drug delivery?
Drewes, L. R., Aug 2014, In: Journal of Cerebral Blood Flow and Metabolism. 34, 8, p. 1257 1 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Monocarboxylic Acid Transporters
Liu, Z. & Drewes, L. R., Sep 2 2014, Drug Transporters: Molecular Characterization and Role in Drug Disposition: Second Edition. Wiley-Blackwell, Vol. 9781118489932. p. 91-106 16 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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News from the editors of Fluids and Barriers of the CNS
Drewes, L. R., Jones, H. C. & Keep, R. F., Jun 17 2014, In: Fluids and Barriers of the CNS. 11, 1, 13.Research output: Contribution to journal › Editorial › peer-review
1 Scopus citations -
2013
Immunologic privilege in the central nervous system and the blood-brain barrier
Muldoon, L. L., Alvarez, J. I., Begley, D. J., Boado, R. J., Del Zoppo, G. J., Doolittle, N. D., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., Prat, A., Scarpa, M., Smeyne, R. J., Drewes, L. R. & Neuwelt, E. A., Jan 2013, In: Journal of Cerebral Blood Flow and Metabolism. 33, 1, p. 13-21 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access227 Scopus citations -
2012
Making connexons in the neurovascular unit
Drewes, L. R., Aug 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 8, p. 1455-1456 2 p.Research output: Contribution to journal › Comment/debate › peer-review
14 Scopus citations -
Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells
Smith, J. P., Uhernik, A. L., Li, L., Liu, Z. & Drewes, L. R., Oct 22 2012, In: Brain Research. 1480, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
2011
Engaging neuroscience to advance translational research in brain barrier biology
Neuwelt, E. A., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O'Donnell, M. E., Povlishock, J. T., Saunders, N. R., Sharp, F., Stanimirovic, D., Watts, R. J. & Drewes, L. R., Mar 2011, In: Nature Reviews Neuroscience. 12, 3, p. 169-182 14 p.Research output: Contribution to journal › Review article › peer-review
473 Scopus citations -
2010
Small-volume D-β-hydroxybutyrate solution infusion increases survivability of lethal hemorrhagic shock in rats
Klein, A. H., Wendroth, S. M., Drewes, L. R. & Andrews, M. T., Dec 2010, In: Shock. 34, 6, p. 565-572 8 p.Research output: Contribution to journal › Article › peer-review
27 Scopus citations -
2009
Adaptive mechanisms regulate preferred utilization of ketones in the heart and brain of a hibernating mammal during arousal from torpor
Andrews, M. T., Russeth, K. P., Drewes, L. R. & Henry, P-G., Feb 2009, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 296, 2, p. R383-R393Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs
Westholm, D. E., Stenehjem, D. D., Rumbley, J. N., Drewes, L. R. & Anderson, G. W., Feb 2009, In: Endocrinology. 150, 2, p. 1025-1032 8 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs
Westholm, D. E., Stenehjem, D. D., Rumbley, J. N., Drewes, L. R. & Anderson, G. W., Feb 2009, In: Endocrinology. 150, 2, p. 1025-1032 8 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
2008
Strategies to advance translational research into brain barriers
Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., Pardridge, W., Rosenberg, G. A., Smith, Q. & Drewes, L. R., Jan 2008, In: The Lancet Neurology. 7, 1, p. 84-96 13 p.Research output: Contribution to journal › Review article › peer-review
393 Scopus citations -
2007
Brain energy metabolism and neurotransmission at near-freezing temperatures: In vivo 1H MRS study of a hibernating mammal
Henry, P-G., Russeth, K. P., Tkac, I., Drewes, L. R., Andrews, M. T. & Gruetter, R., Jun 2007, In: Journal of Neurochemistry. 101, 6, p. 1505-1515 11 p.Research output: Contribution to journal › Article › peer-review
49 Scopus citations -
2006
Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells
Smith, J. P. & Drewes, L. R., Jan 27 2006, In: Journal of Biological Chemistry. 281, 4, p. 2053-2060 8 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Monocarboxylate Transporters
Spanier, J. A. & Drewes, L. R., Nov 20 2006, Drug Transporters: Molecular Characterization and Role in Drug Disposition. John Wiley & Sons, Inc., p. 147-170 24 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
6 Scopus citations -
The rat blood-brain barrier transcriptome
Enerson, B. E. & Drewes, L. R., Jun 19 2006, In: Journal of Cerebral Blood Flow and Metabolism. 26, 7, p. 959-973 15 p.Research output: Contribution to journal › Article › peer-review
174 Scopus citations -
2005
New frontiers in translational research in neuro-oncology and the blood-brain barrier: Report of the Tenth Annual Blood-brain Barrier Disruption Consortium Meeting
Doolittle, N. D., Abrey, L. E., Bleyer, W. A., Brem, S., Davis, T. P., Dore-Duffy, P., Drewes, L. R., Hall, W. A., Hoffman, J. M., Korfel, A., Martuza, R., Muldoon, L. L., Peereboom, D., Peterson, D. R., Rabkin, S. D., Smith, Q., Stevens, G. H. J. & Neuwelt, E. A., Jan 15 2005, In: Clinical Cancer Research. 11, 2 I, p. 421-428 8 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
2003
Immunoblot detection of brain vascular proteins.
Matson, C. T. & Drewes, L. R., 2003, In: Methods in molecular medicine. 89, p. 479-487 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Molecular features, regulation, and function of monocarboxylate transporters: Implications for drug delivery
Enerson, B. E. & Drewes, L. R., Aug 1 2003, In: Journal of Pharmaceutical Sciences. 92, 8, p. 1531-1544 14 p.Research output: Contribution to journal › Short survey › peer-review
180 Scopus citations -
2001
Brain uptake and utilization of fatty acids: Applications to peroxisomal biogenesis disorders (An International Workshop): Roundtable discussion of session 3: The regulation and functions of DHA in neurons and neuronal membranes
Anderson, R., Drewes, L., Ntambi, J., Rapoport, S., Hibbeln, J., Yavin, E., Horrocks, L., Moore, S., Salem, N., Preuss, M., Spector, A., Lagarde, M., Leaf, A., Katz, R., Kim, H. Y. & Horrobin, D., 2001, In: Journal of Molecular Neuroscience. 16, 2-3, p. 279-284 6 p.Research output: Contribution to journal › Article › peer-review
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Brain uptake and utilization of fatty acids: Applications to peroxisomal biogenesis disorders (An International Workshop): Roundtable discussion of session 1: Fatty acid uptake by and transport in the brain
Hamilton, J., Drewes, L., Kyle, D., Rapoport, S., Glatz, J., Abumrad, N., Lagarde, M., Gawrisch, K., Leaf, Pownall, H., Kamp, Schaffer, J. & Storch, J., Jul 31 2001, In: Journal of Molecular Neuroscience. 16, 2-3, p. 151-157 7 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain
Leino, R. L., Gerhart, D. Z., Duelli, R., Enerson, B. E. & Drewes, L. R., 2001, In: Neurochemistry International. 38, 6, p. 519-527 9 p.Research output: Contribution to journal › Article › peer-review
189 Scopus citations -
Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues
Froberg, M. K., Gerhart, D. Z., Enerson, B. E., Manivel, C., Guzman-Paz, M., Seacotte, N. & Drewes, L. R., Mar 26 2001, In: Neuroreport. 12, 4, p. 761-765 5 p.Research output: Contribution to journal › Article › peer-review
72 Scopus citations -
Factor(s) released by glucose-deprived astrocytes enhance glucose transporter expression and activity in rat brain endothelial cells
Régina, A., Morchoisne, S., Borson, N. D., McCall, A. L., Drewes, L. R. & Roux, F., Sep 26 2001, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1540, 3, p. 233-242 10 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations