Nichole R Klatt

Nichole R Klatt

Professor and Director of Division of Surgical Outcomes and Precision Medicine Research, Department of Surgery, School of Medicine, University of Minnesota, Affiliate Professor, Department of Microbiology, Immunology, and Cancer Biology Department, School of Medicine, University of Minnesota

Accepting PhD Students

20072021

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Personal profile

Research Interests

The focus of my laboratory is mucosal immunity, the microbiome, and pharmacomicrobiomics in the context of disease prevention and pathogenesis and human health. My seventy-two peer-reviewed publications in the last 16 years demonstrate my productivity. In eight years of being a PI, I have been invited for fifty-eight oral presentations, including four international plenaries and six international symposia, and a recent keynote plenary at an international HIV meeting, two keynote lectures at domestic meetings, and I recently gave a plenary at the prestigious Conference on Retroviruses and Opportunistic Infections (CROI) in 2018. I recently completed my second term on the AIDS Clinical Trials Inflammation and End Organ Transformation Group. We have a highly cutting-edge study published at Science on our studies of the impact of the microbiome on HIV susceptibility in the context of vaginal pre-exposure prophylaxis (PrEP) where my laboratory led the novel studies that found that vaginal microbiota can metabolize antiretroviral drugs, which may underlie decreased PrEP efficacy. We have expanded these studies and are a leader in the highly novel field of pharmacomicrobiomics. In addition, my laboratory focuses on understanding the microbiome relative to host processes in HIV and other diseases, and to develop novel interventions to treat and prevent mucosal associated disease. Until May 2018, I was a core staff scientist in the Washington National Primate Research Center’s divisions of AIDS and Systems Biology and Director of the mucosal immunology and microbiome core, and an Associate Professor in the School of Pharmacy Department of Pharmaceutics. I then moved to the University of Miami Department of Pediatrics, Miller School of Medicine, where I was Vice Chair of Research and Adrienne Arsht Endowed Chair in Pediatric clinical research, and was a member of the HIV/AIDS Institute, Center for AIDS Research (CFAR), and Sylvester Comprehensive Cancer Center. I was also the director of the CFAR Microbiome working group. In winter 2020, I moved my lab to the University of Minnesota, where I am Professor in Surgery, and Director of the new Division of Surgical Outcomes and Precision Medicine. Currently, the overarching focus of my laboratory is understanding the microbiome relative to drug metabolism and host processes in human health. Here we will provide guidance and expertise for microbiome studies, all sample processing, extractions, experimentation and analysis for microbiome and related studies, and we will work with the study team to integrate these data with clinical outcomes.

Expertise related to UN Sustainable Devlopment Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Emory University

Award Date: Dec 1 2008

PhD, University of Pennsylvania

Award Date: Dec 1 2008

BS, University of Minnesota Duluth

Award Date: May 1 2004

External Positions

Affiliate Associate Professor, Department of Pediatrics, Miller School of Medicine, University of Miami

2020 → …

Affiliate Associate Professor, Department of Pharmaceutics, School of Pharmacy, University of Washington

2018 → …

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