Projects per year
Personal profile
Research Interests
The focus of my laboratory is mucosal immunity, the microbiome, and pharmacomicrobiomics in the context of disease prevention and pathogenesis and human health. My seventy-two peer-reviewed publications in the last 16 years demonstrate my productivity. In eight years of being a PI, I have been invited for fifty-eight oral presentations, including four international plenaries and six international symposia, and a recent keynote plenary at an international HIV meeting, two keynote lectures at domestic meetings, and I recently gave a plenary at the prestigious Conference on Retroviruses and Opportunistic Infections (CROI) in 2018. I recently completed my second term on the AIDS Clinical Trials Inflammation and End Organ Transformation Group. We have a highly cutting-edge study published at Science on our studies of the impact of the microbiome on HIV susceptibility in the context of vaginal pre-exposure prophylaxis (PrEP) where my laboratory led the novel studies that found that vaginal microbiota can metabolize antiretroviral drugs, which may underlie decreased PrEP efficacy. We have expanded these studies and are a leader in the highly novel field of pharmacomicrobiomics. In addition, my laboratory focuses on understanding the microbiome relative to host processes in HIV and other diseases, and to develop novel interventions to treat and prevent mucosal associated disease. Until May 2018, I was a core staff scientist in the Washington National Primate Research Center’s divisions of AIDS and Systems Biology and Director of the mucosal immunology and microbiome core, and an Associate Professor in the School of Pharmacy Department of Pharmaceutics. I then moved to the University of Miami Department of Pediatrics, Miller School of Medicine, where I was Vice Chair of Research and Adrienne Arsht Endowed Chair in Pediatric clinical research, and was a member of the HIV/AIDS Institute, Center for AIDS Research (CFAR), and Sylvester Comprehensive Cancer Center. I was also the director of the CFAR Microbiome working group. In winter 2020, I moved my lab to the University of Minnesota, where I am Professor in Surgery, and Director of the new Division of Surgical Outcomes and Precision Medicine. Currently, the overarching focus of my laboratory is understanding the microbiome relative to drug metabolism and host processes in human health. Here we will provide guidance and expertise for microbiome studies, all sample processing, extractions, experimentation and analysis for microbiome and related studies, and we will work with the study team to integrate these data with clinical outcomes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Immunology & Molecular Pathogenesis, Emory University
Award Date: Dec 1 2008
PhD, Molecular & Cellular Biology, University of Pennsylvania
Award Date: Dec 1 2008
BS, Biology, Chemistry, University of Minnesota Duluth
Award Date: May 1 2004
External Positions
Affiliate Associate Professor, Department of Pediatrics, Miller School of Medicine, University of Miami
2020 → …
Affiliate Associate Professor, Department of Pharmaceutics, School of Pharmacy, University of Washington
2018 → …
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Penile viral and bacterial microbiome, inflammation and HIV susceptibility
SEATTLE CHILDREN'S HOSPITAL, NATIONAL INSTITUTES OF HEALTH (NIH)
6/15/22 → 5/31/24
Project: Research project
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Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized control trial
Ikramuddin, S., Adeyi, O., Billington, C. J., Connett, J. E., Holker, E. G., Klatt, N. R. & Lake, J. R.
NIH NATL INST OF DIABETES/DIG/KIDNEY DIS
7/14/21 → 5/31/24
Project: Research project
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Mechanisms underlying recurrent bacterial vaginosis and HIV risk a multidisciplinary approach
Klatt, N. R. & Schifanella, L.
UNIVERSITY OF MIAMI, NATIONAL INSTITUTES OF HEALTH (NIH)
5/1/20 → 7/31/24
Project: Research project
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Reversing Immune Dysfunction for HIV-1 Eradication
Klatt, N. R. & Schifanella, L.
SCRIPPS RESEARCH INSTITUTE DBA CALIBR, NIH Nat'l Inst of Allergy & Infect Dis
5/1/22 → 4/30/23
Project: Research project
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Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Klatt, N. R. & Schifanella, L.
UNIVERSITY OF MIAMI, NATIONAL INSTITUTES OF HEALTH (NIH)
9/15/21 → 8/31/23
Project: Research project
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Problematic Cannabis Use Is Associated with Reduced Rectal Microbial Species Richness and Diversity Among a Pilot Sample of Young Sexual and Gender Minorities
Morgan, E., Manuzak, J. A., Broedlow, C., Hudson, H., D’Aquila, R., Carrico, A. W., Klatt, N. R. & Mustanski, B., Jan 1 2024, In: AIDS Research and Human Retroviruses. 40, 1, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
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Using unsupervised machine learning to classify behavioral risk markers of bacterial vaginosis
Rodriguez, V. J., Pan, Y., Salazar, A. S., Nogueira, N. F., Raccamarich, P., Klatt, N. R., Jones, D. L. & Alcaide, M. L., Mar 2024, In: Archives of Gynecology and Obstetrics. 309, 3, p. 1053-1063 11 p.Research output: Contribution to journal › Article › peer-review
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Accommodating multiple potential normalizations in microbiome associations studies
Song, H., Ling, W., Zhao, N., Plantinga, A. M., Broedlow, C. A., Klatt, N. R., Hensley-McBain, T. & Wu, M. C., Dec 2023, In: BMC bioinformatics. 24, 1, 22.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Assessing Intravaginal Practices in HIV Prevention Research: Development and Validation of an Intravaginal Practices Questionnaire
Rodriguez, V. J., Salazar, A. S., Cherenack, E. M., Klatt, N. R., Jones, D. L. & Alcaide, M. L., Feb 2023, In: Archives of sexual behavior. 52, 2, p. 803-808 6 p.Research output: Contribution to journal › Article › peer-review
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Gender Identity Stigma in Transgender Women Is Higher After Gender-Affirming Vaginoplasty
Fein, L. A., Barnett, R., Liu, T., Potter, J. N. E., Klatt, N. R., Alcaide, M. L. & Jones, D. L., 2023, (Accepted/In press) In: AIDS Research and Human Retroviruses.Research output: Contribution to journal › Article › peer-review