Research output per year
Research output per year
- 20 results
Search results
-
2024
Aβ∗56 is a stable oligomer that impairs memory function in mice
Liu, P., Lapcinski, I. P., Hlynialuk, C. J. W., Steuer, E. L., Loude, T. J., Shapiro, S. L., Kemper, L. J. & Ashe, K. H., Mar 15 2024, In: iScience. 27, 3, 109239.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Steuer, E. L., Kemper, L. J., Hlynialuk, C. J. W., Leinonen-Wright, K., Montonye, M. L., Lapcinski, I. P., Forster, C. L., Ashe, K. H. & Liu, P., Jun 8 2022, In: Journal of Neuroscience. 42, 23, p. 4737-4754 18 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy
Singh, G., Liu, P., Yao, K. R., Strasser, J. M., Hlynialuk, C., Leinonen-Wright, K., Teravskis, P. J., Choquette, J. M., Ikramuddin, J., Bresinsky, M., Nelson, K. M., Liao, D., Ashe, K. H., Walters, M. A. & Pockes, S., 2022, (Accepted/In press) In: ACS Chemical Neuroscience.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314
Bresinsky, M., Strasser, J. M., Vallaster, B., Liu, P., McCue, W. M., Fuller, J., Hubmann, A., Singh, G., Nelson, K. M., Cuellar, M. E., Wilmot, C. M., Finzel, B. C., Ashe, K. H., Walters, M. A. & Pockes, S., Jan 14 2022, In: ACS Pharmacology and Translational Science. 5, 1, p. 20-40 21 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2021
The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies
Liu, P. & Ashe, K. H., Sep 2021, In: Neural Regeneration Research. 16, 9, p. 1774-1775 2 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
2020
A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals
Liu, P., Smith, B. R., Montonye, M. L., Kemper, L. J., Leinonen-Wright, K., Nelson, K. M., Higgins, L. A., Guerrero, C. R., Markowski, T. W., Zhao, X., Petersen, A. J., Knopman, D. S., Petersen, R. C. & Ashe, K. H., Dec 1 2020, In: Scientific reports. 10, 1, 3869.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Author Correction: A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals (Scientific Reports, (2020), 10, 1, (3869), 10.1038/s41598-020-60777-x)
Liu, P., Smith, B. R., Montonye, M. L., Kemper, L. J., Leinonen-Wright, K., Nelson, K. M., Higgins, L. A., Guerrero, C. R., Markowski, T. W., Zhao, X., Petersen, A. J., Knopman, D. S., Petersen, R. C. & Ashe, K. H., Dec 1 2020, In: Scientific reports. 10, 1, 8077.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Scopus citations -
2019
A Cautionary Tale: Endogenous Biotinylated Proteins and Exogenously-Introduced Protein A Cause Antibody-Independent Artefacts in Western Blot Studies of Brain-Derived Proteins
Grant, M. K. O., Shapiro, S. L., Ashe, K. H., Liu, P. & Zahs, K. R., Apr 18 2019, In: Biological Procedures Online. 21, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients
Liu, P., Smith, B. R., Huang, E. S., Mahesh, A., Vonsattel, J. P. G., Petersen, A. J., Gomez-Pastor, R. & Ashe, K. H., Jul 30 2019, In: Acta Neuropathologica Communications. 7, 1, p. 111 1 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Human cerebrospinal fluid 6E10- immunoreactive protein species contain amyloid precursor protein fragments
Grant, M. K. O., Handoko, M., Rozga, M., Brinkmalm, G., Portelius, E., Blennow, K., Ashe, K. H., Zahs, K. R. & Liu, P., Feb 2019, In: PloS one. 14, 2, e0212815.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2017
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice
Liu, P., Reichl, J. H., Rao, E. R., McNellis, B. M., Huang, E. S., Hemmy, L. S., Forster, C. L., Kuskowski, M. A., Borchelt, D. R., Vassar, R., Ashe, K. H. & Zahs, K. R., 2017, In: Journal of Alzheimer's Disease. 56, 2, p. 743-761 19 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2015
Characterization of a novel mouse model of Alzheimer's disease - Amyloid pathology and unique β-amyloid oligomer profile
Liu, P., Paulson, J. B., Forster, C. L., Shapiro, S. L., Ashe, K. H. & Zahs, K. R., May 6 2015, In: PloS one. 10, 5, e0126317.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite plasmodium berghei
Liu, P., Robbins, A. H., Marzahn, M. R., McClung, S. H., Yowell, C. A., Stevens, S. M., Dame, J. B. & Dunn, B. M., Oct 28 2015, In: PloS one. 10, 10, e0141758.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration
Liu, P., Reed, M. N., Kotilinek, L. A., Grant, M. K. O., Forster, C. L., Qiang, W., Shapiro, S. L., Reichl, J. H., Chiang, A. C. A., Jankowsky, J. L., Wilmot, C. M., Cleary, J. P., Zahs, K. R. & Ashe, K. H., Jun 23 2015, In: Cell reports. 11, 11, p. 1760-1771 12 p.Research output: Contribution to journal › Article › peer-review
123 Scopus citations -
2012
Antiplasmodial activities of 4-aminoquinoline-statine compounds
Vaiana, N., Marzahn, M., Parapini, S., Liu, P., Dell'Agli, M., Pancotti, A., Sangiovanni, E., Basilico, N., Bosisio, E., Dunn, B. M., Taramelli, D. & Romeo, S., Sep 15 2012, In: Bioorganic and Medicinal Chemistry Letters. 22, 18, p. 5915-5918 4 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2011
Grape seed polyphenolic extract specifically decreases Aβ*56 in the brains of Tg2576 mice
Liu, P., Kemper, L. J., Wang, J., Zahs, K. R., Ashe, K. H. & Pasinetti, G. M., 2011, In: Journal of Alzheimer's Disease. 26, 4, p. 657-666 10 p.Research output: Contribution to journal › Article › peer-review
49 Scopus citations -
2010
Effect size of reference memory deficits in the Morris water maze in Tg2576 mice
Reed, M. N., Liu, P., Kotilinek, L. A. & Ashe, K. H., Sep 2010, In: Behavioural Brain Research. 212, 1, p. 115-120 6 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
2009
Recombinant plasmepsin 1 from the human malaria parasite Plasmodium falciparum: Enzymatic characterization, active site inhibitor design, and structural analysis
Liu, P., Marzahn, M. R., Robbins, A. H., Gutiéerrez-de-Terán, H., Rodríguez, D., McClung, S. H., Stevens, S. M., Yowell, C. A., Dame, J. B., McKenna, R. & Dunn, B. M., May 19 2009, In: Biochemistry. 48, 19, p. 4086-4099 14 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2006
High antiplasmodial activity of novel plasmepsins I and II inhibitors
Dell'Agli, M., Parapini, S., Galli, G., Vaiana, N., Taramelli, D., Sparatore, A., Liu, P., Dunn, B. M., Bosisio, E. & Romeo, S., Dec 14 2006, In: Journal of medicinal chemistry. 49, 25, p. 7440-7449 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum
Gutiérrez-De-Terán, H., Nervall, M., Ersmark, K., Liu, P., Janka, L. K., Dunn, B., Hallberg, A. & Åqvist, J., Sep 5 2006, In: Biochemistry. 45, 35, p. 10529-10541 13 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations