Research output

Research output per year 2007 2019 2021 2024

• 53 Article
• 6 Review article
• 1 Working paper

Research output per year

Research output per year

Search results

• 2024

  Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination

  Sanders, A. E., Arnesen, H., Shepherd, F., Putri, D. S., Fiege, J. K., Pierson, M. J., Roach, S. N., Carlsen, H., Masopust, D., Boysen, P. & Langlois, R. A., Feb 2024, In: mSphere. 9, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Synthetic Cell Lines for Inducible Packaging of Influenza A Virus

  Phan, T., Ye, Q., Stach, C., Lin, Y. C., Cao, H., Bowen, A., Langlois, R. A. & Hu, W. S., Feb 16 2024, In: ACS Synthetic Biology. 13, 2, p. 546-557 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Artificial Cells 100%
  • Viruses 83%
  • Product Packaging 82%
  • Influenza A virus 78%
  • Cells 69%
• 2023

  Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

  King, C. R., Liu, Y., Amato, K. A., Schaack, G. A., Mickelson, C., Sanders, A. E., Hu, T., Gupta, S., Langlois, R. A., Smith, J. A. & Mehle, A., Sep 13 2023, In: Cell Host and Microbe. 31, 9, p. 1552-1567.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 96%
  • Virus Diseases 62%
  • pathogens 49%
  • DNA 47%
  2 Scopus citations

• Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

  Jaeger, A. S., Crooks, C. M., Weiler, A. M., Bliss, M. I., Rybarczyk, S., Richardson, A., Einwalter, M., Peterson, E., Capuano, S., Barkhymer, A., Becker, J. T., Greene, J. T., Freedman, T. S., Langlois, R. A., Friedrich, T. C. & Aliota, M. T., Jun 2023, In: Science Advances. 9, 26, eadg3444.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zika Virus Infection 100%
  • Zika Virus 75%
  • Macaca mulatta 75%
  • Virus Diseases 52%
  • Viruses 47%

• Respiratory viruses: New frontiers—a Keystone Symposia report

  Cable, J., Sun, J., Cheon, I. S., Vaughan, A. E., Castro, I. A., Stein, S. R., López, C. B., Gostic, K. M., Openshaw, P. J. M., Ellebedy, A. H., Wack, A., Hutchinson, E., Thomas, M. M., Langlois, R. A., Lingwood, D., Baker, S. F., Folkins, M., Foxman, E. F., Ward, A. B., Schwemmle, M., & 7 othersRussell, A. B., Chiu, C., Ganti, K., Subbarao, K., Sheahan, T. P., Penaloza-MacMaster, P. & Eddens, T., Apr 2023, In: Annals of the New York Academy of Sciences. 1522, 1, p. 60-73 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Keystone 100%
  • Virus 75%
  • Strain 52%
  • Viruses 50%
  • Resistance 47%

• Virology under the Microscope-a Call for Rational Discourse

  Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 othersCameron, C., Campos, S., Caposio, P., Chan, G., Cliffe, A., Coffin, J., Collins, K., Damania, B., Daugherty, M., Debbink, K., DeCaprio, J., Dermody, T., Dikeakos, J., DiMaio, D., Dinglasan, R., Duprex, W. P., Dutch, R., Elde, N., Emerman, M., Enquist, L., Fane, B., Fernandez-Sesma, A., Flenniken, M., Frappier, L., Frieman, M., Frueh, K., Gack, M., Gaglia, M., Gallagher, T., Galloway, D., García-Sastre, A., Geballe, A., Glaunsinger, B., Goff, S., Greninger, A., Hancock, M., Harris, E., Heaton, N., Heise, M., Heldwein, E., Hogue, B., Horner, S., Hutchinson, E., Hyser, J., Jackson, W., Kalejta, R., Kamil, J., Karst, S., Kirchhoff, F., Knipe, D., Kowalik, T., Lagunoff, M., Laimins, L., Langlois, R., Lauring, A., Lee, B., Leib, D., Liu, S. L., Longnecker, R., Lopez, C., Luftig, M., Lund, J., Manicassamy, B., McFadden, G., McIntosh, M., Mehle, A., Miller, W. A., Mohr, I., Moody, C., Moorman, N., Moscona, A., Mounce, B., Munger, J., Münger, K., Murphy, E., Naghavi, M., Nelson, J., Neufeldt, C., Nikolich, J., O'Connor, C., Ono, A., Orenstein, W., Ornelles, D., Ou, J. H., Parker, J., Parrish, C., Pekosz, A., Pellett, P., Pfeiffer, J., Plemper, R., Polyak, S., Purdy, J., Pyeon, D., Quinones-Mateu, M., Renne, R., Rice, C., Schoggins, J., Roller, R., Russell, C., Sandri-Goldin, R., Sapp, M., Schang, L., Schmid, S., Schultz-Cherry, S., Semler, B., Shenk, T., Silvestri, G., Simon, V., Smith, G., Smith, J., Spindler, K., Stanifer, M., Subbarao, K., Sundquist, W., Suthar, M., Sutton, T., Tai, A., Tarakanova, V., tenOever, B., Tibbetts, S., Tompkins, S., Toth, Z., van Doorslaer, K., Vignuzzi, M., Wallace, N., Walsh, D., Weekes, M., Weinberg, J., Weitzman, M., Weller, S., Whelan, S., White, E., Williams, B., Wobus, C., Wong, S. & Yurochko, A., Jan 2023, In: mBio. 14, 1

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Virology 100%
  • SARS Virus 45%
  • Viruses 20%
  • Pandemics 16%
  • Administrative Personnel 15%
  1 Scopus citations

• Virology under the Microscope—a Call for Rational Discourse

  Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 othersCameron, C., Campos, S., Caposio, P., Chan, G., Cliffe, A., Coffin, J., Collins, K., Damania, B., Daugherty, M., Debbink, K., DeCaprio, J., Dermody, T., Dikeakos, J., DiMaio, D., Dinglasan, R., Duprex, W. P., Dutch, R., Elde, N., Emerman, M., Enquist, L., Fane, B., Fernandez-Sesma, A., Flenniken, M., Frappier, L., Frieman, M., Frueh, K., Gack, M., Gaglia, M., Gallagher, T., Galloway, D., García-Sastre, A., Geballe, A., Glaunsinger, B., Goff, S., Greninger, A., Hancock, M., Harris, E., Heaton, N., Heise, M., Heldwein, E., Hogue, B., Horner, S., Hutchinson, E., Hyser, J., Jackson, W., Kalejta, R., Kamil, J., Karst, S., Kirchhoff, F., Knipe, D., Kowalik, T., Lagunoff, M., Laimins, L., Langlois, R., Lauring, A., Lee, B., Leib, D., Liu, S. L., Longnecker, R., Lopez, C., Luftig, M., Lund, J., Manicassamy, B., McFadden, G., McIntosh, M., Mehle, A., Miller, W. A., Mohr, I., Moody, C., Moorman, N., Moscona, A., Mounce, B., Munger, J., Münger, K., Murphy, E., Naghavi, M., Nelson, J., Neufeldt, C., Nikolich, J., O'Connor, C., Ono, A., Orenstein, W., Ornelles, D., Ou, J. H., Parker, J., Parrish, C., Pekosz, A., Pellett, P., Pfeiffer, J., Plemper, R., Polyak, S., Purdy, J., Pyeon, D., Quinones-Mateu, M., Renne, R., Rice, C., Schoggins, J., Roller, R., Russell, C., Sandri-Goldin, R., Sapp, M., Schang, L., Schmid, S., Schultz-Cherry, S., Semler, B., Shenk, T., Silvestri, G., Simon, V., Smith, G., Smith, J., Spindler, K., Stanifer, M., Subbarao, K., Sundquist, W., Suthar, M., Sutton, T., Tai, A., Tarakanova, V., tenOever, B., Tibbetts, S., Tompkins, S., Toth, Z., van Doorslaer, K., Vignuzzi, M., Wallace, N., Walsh, D., Weekes, M., Weinberg, J., Weitzman, M., Weller, S., Whelan, S., White, E., Williams, B., Wobus, C., Wong, S. & Yurochko, A., Feb 2023, In: Journal of virology. 97, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • virology 100%
  • Virology 97%
  • SARS Virus 44%
  • burden of disease 22%
  • Viruses 20%
  8 Scopus citations

• Virology under the Microscope—a Call for Rational Discourse

  Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 othersCameron, C., Campos, S., Caposio, P., Chan, G., Cliffe, A., Coffin, J., Collins, K., Damania, B., Daugherty, M., Debbink, K., DeCaprio, J., Dermody, T., Dikeakos, J., DiMaio, D., Dinglasan, R., Duprex, W. P., Dutch, R., Elde, N., Emerman, M., Enquist, L., Fane, B., Fernandez-Sesma, A., Flenniken, M., Frappier, L., Frieman, M., Frueh, K., Gack, M., Gaglia, M., Gallagher, T., Galloway, D., García-Sastre, A., Geballe, A., Glaunsinger, B., Goff, S., Greninger, A., Hancock, M., Harris, E., Heaton, N., Heise, M., Heldwein, E., Hogue, B., Horner, S., Hutchinson, E., Hyser, J., Jackson, W., Kalejta, R., Kamil, J., Karst, S., Kirchhoff, F., Knipe, D., Kowalik, T., Lagunoff, M., Laimins, L., Langlois, R., Lauring, A., Lee, B., Leib, D., Liu, S. L., Longnecker, R., Lopez, C., Luftig, M., Lund, J., Manicassamy, B., McFadden, G., McIntosh, M., Mehle, A., Miller, W. A., Mohr, I., Moody, C., Moorman, N., Moscona, A., Mounce, B., Munger, J., Münger, K., Murphy, E., Naghavi, M., Nelson, J., Neufeldt, C., Nikolich, J., O'Connor, C., Ono, A., Orenstein, W., Ornelles, D., Ou, J. H., Parker, J., Parrish, C., Pekosz, A., Pellett, P., Pfeiffer, J., Plemper, R., Polyak, S., Purdy, J., Pyeon, D., Quinones-Mateu, M., Renne, R., Rice, C., Schoggins, J., Roller, R., Russell, C., Sandri-Goldin, R., Sapp, M., Schang, L., Schmid, S., Schultz-Cherry, S., Semler, B., Shenk, T., Silvestri, G., Simon, V., Smith, G., Smith, J., Spindler, K., Stanifer, M., Subbarao, K., Sundquist, W., Suthar, M., Sutton, T., Tai, A., Tarakanova, V., tenOever, B., Tibbetts, S., Tompkins, S., Toth, Z., van Doorslaer, K., Vignuzzi, M., Wallace, N., Walsh, D., Weekes, M., Weinberg, J., Weitzman, M., Weller, S., Whelan, S., White, E., Williams, B., Wobus, C., Wong, S. & Yurochko, A., Apr 2023, In: mSphere. 8, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Virology 100%
  • SARS Virus 45%
  • Viruses 20%
  • Pandemics 16%
  • Administrative Personnel 15%
  1 Scopus citations
• 2022

  Boosting corrects a memory B cell defect in SARS-CoV-2 mRNA-vaccinated patients with inflammatory bowel disease

  Pape, K. A., Dileepan, T., Matchett, W. E., Ellwood, C., Stresemann, S., Kabage, A. J., Kozysa, D., Evert, C., Matson, M., Lopez, S., Krueger, P. D., Graiziger, C. T., Vaughn, B. P., Shmidt, E., Rhein, J., Schacker, T. W., Bold, T. D., Langlois, R. A., Khoruts, A. & Jenkins, M. K., Jun 22 2022, In: JCI Insight. 7, 12, e159618.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Inflammatory Bowel Diseases 64%
  • B-Lymphocytes 52%
  • Messenger RNA 38%
  • Antibody-Producing Cells 25%
  4 Scopus citations

• Characterization of influenza A virus induced transposons reveals a subgroup of transposons likely possessing the regulatory role as eRNAs

  Shen, S. S., Nanda, H., Aliferis, C. & Langlois, R. A., Dec 2022, In: Scientific reports. 12, 1, 2188.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza A virus 100%
  • RNA 63%
  • Viruses 60%
  • Host Microbial Interactions 38%
  • Chromatin 26%
  2 Scopus citations

• Embracing the heterogeneity of natural viruses in mouse studies

  Fiege, J. K. & Langlois, R. A., 2022, In: Journal of General Virology. 103, 6, 001758.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Microbiota 100%
  • Animal Models 72%
  • Viruses 67%
  • Epidemiologic Confounding Factors 58%
  2 Scopus citations

• Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

  Kenney, A. D., Aron, S. L., Gilbert, C., Kumar, N., Chen, P., Eddy, A., Zhang, L., Zani, A., Vargas-Maldonado, N., Speaks, S., Kawahara, J., Denz, P. J., Dorn, L., Accornero, F., Ma, J., Zhu, H., Rajaram, M. V. S., Cai, C., Langlois, R. A. & Yount, J. S., May 2022, In: Science Advances. 8, 19, eabm5371.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • Virus Replication 99%
  • Cardiac Myocytes 92%
  • Fibrosis 73%
  • Viruses 66%
  8 Scopus citations

• Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine

  Roach, S. N., Fiege, J. K., Shepherd, F. K., Wiggen, T. D., Hunter, R. C. & Langlois, R. A., May 2022, In: Journal of virology. 96, 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • Small Intestine 77%
  • small intestine 76%
  • lymphocytes 69%
  • Virus Diseases 62%
  16 Scopus citations
• 2021

  A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19

  Puskarich, M. A., Cummins, N. W., Ingraham, N. E., Wacker, D. A., Reilkoff, R. A., Driver, B. E., Biros, M. H., Bellolio, F., Chipman, J. G., Nelson, A. C., Beckman, K., Langlois, R., Bold, T., Aliota, M. T., Schacker, T. W., Voelker, H. T., Murray, T. A., Koopmeiners, J. S. & Tignanelli, C. J., Jul 2021, In: EClinicalMedicine. 37, 100957.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phase II Clinical Trials 100%
  • Losartan 98%
  • Outpatients 61%
  • Randomized Controlled Trials 55%
  • Placebos 35%
  52 Scopus citations

• Cutting edge: Mouse sars-cov-2 epitope reveals infection and vaccine-elicited cd8 t cell responses

  Joag, V., Wijeyesinghe, S. P., Stolley, J. M., Quarnstrom, C. F., Dileepan, T., Soerens, A. G., Sangala, J. A., O'Flanagan, S. D., Gavil, N. V., Hong, S. W., Bhela, S., Gangadhara, S., Weyu, E., Matchett, W. E., Thiede, J., Krishna, V., Cheeran, M. C. J., Bold, T. D., Amara, R., Southern, P., & 6 othersHart, G. T., Schifanella, L., Vezys, V., Jenkins, M. K., Langlois, R. A. & Masopust, D., Mar 1 2021, In: Journal of Immunology. 206, 5, p. 931-935 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epitopes 100%
  • Vaccines 87%
  • SARS Virus 85%
  • T-Lymphocytes 72%
  • Infections 55%
  25 Scopus citations

• Cutting edge: Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

  Matchett, W. E., Joag, V., Stolley, J. M., Shepherd, F. K., Quarnstrom, C. F., Mickelson, C. K., Wijeyesinghe, S., Soerens, A. G., Becker, S., Thiede, J. M., Weyu, E., O'Flanagan, S. D., Walter, J. A., Vu, M. N., Menachery, V. D., Bold, T. D., Vezys, V., Jenkins, M. K., Langlois, R. A. & Masopust, D., Jul 15 2021, In: Journal of Immunology. 207, 2, p. 376-379 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nucleocapsid 100%
  • Severe Acute Respiratory Syndrome 97%
  • Coronavirus 95%
  • Immunity 61%
  • Vaccines 56%
  94 Scopus citations

• Genetic ancestry effects on the response to viral infection are pervasive but cell type specific

  Randolph, H. E., Fiege, J. K., Thielen, B. K., Mickelson, C. K., Shiratori, M., Barroso-Batista, J., Langlois, R. A. & Barreiro, L. B., Nov 26 2021, In: Science. 374, 6571, p. 1127-1133 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Virus Diseases 100%
  • Infections 64%
  • Quantitative Trait Loci 57%
  • Interferon Type I 53%
  • RNA Sequence Analysis 50%
  43 Scopus citations

• Immune Profiling to Determine Early Disease Trajectories Associated With Coronavirus Disease 2019 Mortality Rate: A Substudy from the ACTT-1 Trial

  Thiede, J. M., Gress, A. R., Libby, S. D., Ronayne, C. E., Matchett, W. E., Noren, B., Billings, J. L., Menachery, V. D., Langlois, R. A., Kline, S. & Bold, T. D., Apr 15 2021, In: Journal of Infectious Diseases. 223, 8, p. 1339-1344 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GS-5734 100%
  • Coronavirus 88%
  • Cytokines 43%
  • Antibody Formation 42%
  • Mortality 35%
  2 Scopus citations

• Intra-and cross-species transmission of astroviruses

  Roach, S. N. & Langlois, R. A., Jun 2021, In: Viruses. 13, 6, 1127.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mamastrovirus 100%
  • RNA Viruses 66%
  • Gastroenteritis 65%
  • Zoonoses 63%
  • Infections 56%
  23 Scopus citations

• Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

  Ubah, O. C., Lake, E. W., Gunaratne, G. S., Gallant, J. P., Fernie, M., Robertson, A. J., Marchant, J. S., Bold, T. D., Langlois, R. A., Matchett, W. E., Thiede, J. M., Shi, K., Yin, L., Moeller, N. H., Banerjee, S., Ferguson, L., Kovaleva, M., Porter, A. J., Aihara, H., LeBeau, A. M., & 1 othersBarelle, C. J., Dec 2021, In: Nature communications. 12, 1, 7325.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sharks 100%
  • SARS Virus 89%
  • Sharks 87%
  • X Ray Crystallography 82%
  • antigens 77%
  21 Scopus citations

• Mice with diverse microbial exposure histories as a model for preclinical vaccine testing

  Fiege, J. K., Block, K. E., Pierson, M. J., Nanda, H., Shepherd, F. K., Mickelson, C. K., Stolley, J. M., Matchett, W. E., Wijeyesinghe, S., Meyerholz, D. K., Vezys, V., Shen, S. S., Hamilton, S. E., Masopust, D. & Langlois, R. A., Dec 8 2021, In: Cell Host and Microbe. 29, 12, p. 1815-1827.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • vaccines 100%
  • history 88%
  • Vaccines 87%
  • mice 67%
  • testing 45%
  30 Scopus citations

• Natural rodent model of viral transmission reveals biological features of virus population dynamics

  Fay, E. J., Balla, K. M., Roach, S. N., Shepherd, F. K., Putri, D. S., Wiggen, T. D., Goldstein, S. A., Pierson, M. J., Ferris, M. T., Thefaine, C. E., Tucker, A., Salnikov, M., Cortez, V., Compton, S. R., Kotenko, S. V., Hunter, R. C., Masopust, D., Elde, N. C. & Langlois, R. A., Dec 27 2021, In: Journal of Experimental Medicine. 219, 2, e20211220.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Population Dynamics 100%
  • Rodentia 69%
  • Viruses 55%
  • Pets 32%
  • Astroviridae 27%
  13 Scopus citations

• SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with nonsevere disease

  Gniadek, T. J., Thiede, J. M., Matchett, W. E., Gress, A. R., Pape, K. A., Fiege, J. K., Jenkins, M. K., Menachery, V. D., Langlois, R. A. & Bold, T. D., Jan 2021, In: Transfusion. 61, 1, p. 17-23 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Serology 71%
  • Antigens 43%
  • Passive Immunization 41%
  • Viral Antigens 40%
  20 Scopus citations

• Segment-specific kinetics of mRNA, cRNA, and vRNA accumulation during influenza virus infection

  Phan, T., Fay, E. J., Lee, Z., Aron, S., Hu, W. S. & Langlois, R. A., May 2021, In: Journal of virology. 95, 10, e02102-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Complementary RNA 100%
  • Orthomyxoviridae 89%
  • Influenza A virus 83%
  • Viral RNA 82%
  • Virus Diseases 55%
  23 Scopus citations

• Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

  Fiege, J. K., Thiede, J. M., Nanda, H. A., Matchett, W. E., Moore, P. J., Montanari, N. R., Thielen, B. K., Daniel, J., Stanley, E., Hunter, R. C., Menachery, V. D., Shen, S. S., Bold, T. D. & Langlois, R. A., Jan 28 2021, In: PLoS pathogens. 17, 1, e1009292.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • tropisms 92%
  • Tropism 81%
  • Antiviral Agents 58%
  • epithelium 54%
  51 Scopus citations

• Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells

  Krueger, P. D., Goldberg, M. F., Hong, S. W., Osum, K. C., Langlois, R. A., Kotov, D. I., Dileepan, T. & Jenkins, M. K., Apr 13 2021, In: Immunity. 54, 4, p. 687-701.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Th1 Cells 100%
  • Salmonella enterica 45%
  • Interleukin-12 38%
  • Salmonella Infections 30%
  • Interferons 22%
  25 Scopus citations
• 2020

  Cell type- And replication stage-specific influenza virus responses in vivo

  Fay, E. J., Aron, S. L., Macchietto, M. G., Markman, M. W., Esser-Nobis, K., Gale, M., Shen, S. & Langlois, R. A., Aug 2020, In: PLoS pathogens. 16, 8, e1008760.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • Influenza A virus 93%
  • virus replication 75%
  • Antiviral Agents 72%
  • Virus Replication 56%
  13 Scopus citations

• Kinetically distinct processing pathways diversify the CD8⁺ T cell response to a single viral epitope

  Cosma, G. L., Lobby, J. L., Fay, E. J., Siciliano, N. A., Langlois, R. A. & Eisenlohr, L. C., Aug 11 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 32, p. 19399-19407 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epitopes 100%
  • Peptides 74%
  • T-Lymphocytes 72%
  • Glycoproteins 39%
  • Kinetics 33%
  7 Scopus citations

• Retrograde migration supplies resident memory t cells to lung-draining ln after influenza infection

  Stolley, J. M., Johnston, T. S., Soerens, A. G., Beura, L. K., Rosato, P. C., Joag, V., Wijeyesinghe, S. P., Langlois, R. A., Osum, K. C., Mitchell, J. S. & Masopust, D., Aug 3 2020, In: Journal of Experimental Medicine. 217, 8, e20192197.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human Influenza 100%
  • Memory 79%
  • Lung 58%
  • T-Lymphocytes 53%
  • Infections 51%
  66 Scopus citations

• Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

  Fiege, J. K., Thiede, J., Matchett, W. E., Moore, P., Rico Montanari, N. A., Thielen, B. K., Daniel, J. J., Stanley, E. R., Hunter, R. C., Menachery, V. D., Shen, S., Bold, T. D. & Langlois, R. A., 2020.

  Research output: Working paper

• Virus-induced transposable element expression up-regulation in human and mouse host cells

  Macchietto, M. G., Langlois, R. A. & Shen, S. S., 2020, In: Life science alliance. 3, 2, e201900536.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Transposable Elements 100%
  • virus 75%
  • Wave 72%
  • transposons 71%
  • infection 60%
  29 Scopus citations
• 2019

  Dendritic cell NLRC4 regulates influenza A virus-specific CD4⁺ T cell responses through FasL expression

  Hornick, E. E., Dagvadorj, J., Zacharias, Z. R., Miller, A. M., Langlois, R. A., Chen, P., Legge, K. L., Bishop, G. A., Sutterwala, F. S. & Cassel, S. L., 2019, In: Journal of Clinical Investigation. 129, 7, p. 2888-2897 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza A virus 100%
  • Dendritic Cells 81%
  • T-Lymphocytes 56%
  • Infections 16%
  • Phenotype 13%
  17 Scopus citations

• Engineered small-molecule control of influenza A virus replication

  Fay, E. J., Aron, S. L., Stone, I. A., Waring, B. M., Plemper, R. K. & Langlois, R. A., Jan 1 2019, In: Journal of virology. 93, 1, e01677-18.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • virus replication 100%
  • Influenza A virus 98%
  • Virus Replication 89%
  • vaccines 76%
  • Vaccines 67%
  8 Scopus citations

• Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

  Hemann, E. A., Green, R., Turnbull, J. B., Langlois, R. A., Savan, R. & Gale, M., Aug 1 2019, In: Nature immunology. 20, 8, p. 1035-1045 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza A virus 100%
  • Interferons 83%
  • Dendritic Cells 81%
  • Immunity 74%
  • T-Lymphocytes 56%
  77 Scopus citations

• Long-term surviving influenza infected cells evade CD8⁺ T cell mediated clearance

  Fiege, J. K., Stone, I. A., Dumm, R. E., Waring, B. M., Fife, B. T., Agudo, J., Brown, B. D., Heaton, N. S. & Langlois, R. A., 2019, In: PLoS pathogens. 15, 9, e1008077.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • influenza 100%
  • Human Influenza 78%
  • T-lymphocytes 77%
  • T-Lymphocytes 52%
  • Influenza A virus 43%
  14 Scopus citations

• Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function

  Dumm, R. E., Fiege, J. K., Waring, B. M., Kuo, C. T., Langlois, R. A. & Heaton, N. S., Dec 1 2019, In: Nature communications. 10, 1, 779.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytopathic 100%
  • influenza 97%
  • Influenza B virus 86%
  • clearances 76%
  • viruses 76%
  22 Scopus citations

• TCR affinity biases th cell differentiation by regulating CD25, EEF1E1, and GBP2

  Kotov, D. I., Mitchell, J. S., Pengo, T., Ruedl, C., Way, S. S., Langlois, R. A., Fife, B. T. & Jenkins, M. K., May 1 2019, In: Journal of Immunology. 202, 9, p. 2535-2545 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Differentiation 100%
  • Dendritic Cells 82%
  • T-Lymphocytes 76%
  • Histocompatibility Antigens Class II 67%
  • Interleukin-2 27%
  41 Scopus citations

• The impact of TCR signal strength on resident memory T cell formation during influenza virus infection

  Fiege, J. K., Stone, I. A., Fay, E. J., Markman, M. W., Wijeyesinghe, S., Macchietto, M., Shen, S., Masopust, D. & Langlois, R. A., Aug 15 2019, In: Journal of Immunology. 203, 4, p. 936-945 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • Virus Diseases 72%
  • Influenza A virus 65%
  • T-Lymphocytes 61%
  • Lung 53%
  27 Scopus citations
• 2018

  Distinct antiviral signatures revealed by the magnitude and round of influenza virus replication in vivo

  Sjaastad, L. E., Fay, E. J., Fiege, J. K., Macchietto, M. G., Stone, I. A., Markman, M. W., Shen, S. & Langlois, R. A., Sep 18 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9610-9615 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • Virus Replication 99%
  • Antiviral Agents 84%
  • Viruses 33%
  • Epithelial Cells 23%
  26 Scopus citations

• Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection

  Schmidt, M. E., Knudson, C. J., Hartwig, S. M., Pewe, L. L., Meyerholz, D. K., Langlois, R. A., Harty, J. T. & Varga, S. M., Jan 2018, In: PLoS pathogens. 14, 1, e1006810.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • immunopathology 100%
  • Respiratory syncytial virus 93%
  • Respiratory Syncytial Virus Infections 81%
  • T-lymphocytes 57%
  • Respiratory Syncytial Viruses 42%
  79 Scopus citations

• MicroRNA-Attenuated virus vaccines

  Fay, E. J. & Langlois, R. A., Oct 2 2018, In: Non-coding RNA. 4, 4, 25.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Attenuated Vaccines 100%
  • MicroRNA 98%
  • Safety 68%
  • MicroRNAs 67%
  • Viruses 53%
  14 Scopus citations

• MicroRNA-based attenuation of influenza virus across susceptible hosts

  Waring, B. M., Sjaastad, L. E., Fiege, J. K., Fay, E. J., Reyes, I., Moriarity, B. & Langlois, R. A., Jan 1 2018, In: Journal of virology. 92, 2, e01741-17.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Orthomyxoviridae 100%
  • microRNA 85%
  • MicroRNAs 71%
  • Influenza A virus 70%
  • Livestock 61%
  37 Scopus citations
• 2016

  Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity

  Hamilton, J. R., Sachs, D., Lim, J. K., Langlois, R. A., Palese, P. & Heaton, N. S., Apr 5 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3861-3866 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Influenza A virus 100%
  • Antiviral Agents 78%
  • Immunity 74%
  • Virus Diseases 66%
  • Cre recombinase 30%
  37 Scopus citations

• Plasmacytoid dendritic cells require direct infection to sustain the pulmonary influenza A virusspecific CD8 T cell response

  Hemann, E. A., Sjaastad, L. E., Langlois, R. A. & Legge, K. L., 2016, In: Journal of virology. 90, 6, p. 2830-2837 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • dendritic cells 100%
  • influenza 89%
  • Influenza A virus 84%
  • Human Influenza 69%
  • T-lymphocytes 69%
  15 Scopus citations
• 2015

  Investigating influenza A virus infection: Tools to track infection and limit tropism

  Fiege, J. K. & Langlois, R. A., 2015, In: Journal of virology. 89, 12, p. 6167-6170 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tropisms 100%
  • Tropism 88%
  • Influenza A virus 81%
  • Virus Diseases 54%
  • infection 38%
  25 Scopus citations
• 2014

  Long-term survival of influenza virus infected club cells drives immunopathology

  Heaton, N. S., Langlois, R. A., Sachs, D., Lim, J. K., Palese, P. & tenOever, B. R., 2014, In: Journal of Experimental Medicine. 211, 9, p. 1707-1714 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Orthomyxoviridae 100%
  • Virus Diseases 43%
  • Influenza A virus 43%
  • Viruses 26%
  • Lung 21%
  70 Scopus citations

• The Mammalian Response to Virus Infection Is Independent of Small RNA Silencing

  Backes, S., Langlois, R. A., Schmid, S., Varble, A., Shim, J. V., Sachs, D. & tenOever, B. R., Jul 10 2014, In: Cell reports. 8, 1, p. 114-125 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Silencing RNA 100%
  • RNA Interference 74%
  • Interferons 71%
  • Virus Diseases 56%
  • Antiviral Agents 53%
  64 Scopus citations

• The Mammalian Response to Virus Infection Is Independent of Small RNA Silencing

  Backes, S., Langlois, R. A., Schmid, S., Varble, A., Shim, J. V., Sachs, D. & tenOever, B. R., Jul 10 2014, In: Cell reports. 8, 1, p. 114-125 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Silencing RNA 100%
  • RNA Interference 74%
  • Interferons 71%
  • Virus Diseases 56%
  • Antiviral Agents 53%
  64 Scopus citations
• 2013

  Influenza A Virus Utilizes Suboptimal Splicing to Coordinate the Timing of Infection

  Chua, M. A., Schmid, S., Perez, J. T., Langlois, R. A. & tenOever, B. R., Jan 31 2013, In: Cell reports. 3, 1, p. 23-29 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Influenza A virus 100%
  • Cell Nucleus Active Transport 71%
  • Viruses 60%
  • Infections 43%
  • Antagonist 42%
  70 Scopus citations

• MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

  Langlois, R. A., Albrecht, R. A., Kimble, B., Sutton, T., Shapiro, J. S., Finch, C., Angel, M., Chua, M. A., Gonzalez-Reiche, A. S., Xu, K., Perez, D., García-Sastre, A. & Tenoever, B. R., Sep 2013, In: Nature biotechnology. 31, 9, p. 844-847 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MicroRNA 100%
  • Viruses 95%
  • Influenza A virus 89%
  • Ferrets 83%
  • Human Influenza 75%
  73 Scopus citations