Tinen L Iles

2024

HPC Framework for Performing in Silico Trials Using a 3D Virtual Human Cardiac Population as Means to Assess Drug-Induced Arrhythmic Risk

Aguado-Sierra, J., Brigham, R., Baron, A. K., Gomez, P. D., Houzeaux, G., Guerra, J. M., Carreras, F., Filgueiras-Rama, D., Vazquez, M., Iaizzo, P. A., Iles, T. L. & Butakoff, C., 2024, In: Methods in molecular biology (Clifton, N.J.). 2716, p. 307-334 28 p.

Research output: Contribution to journal › Article › peer-review

2023

Heart Valves: From Design to Clinical Implantation

Iaizzo, P. A., Iles, T. L., Griselli, M. & Louis, J. D., Jan 1 2023, Springer Science+Business Media. 615 p.

Research output: Book/Report › Book

Metabolic Adaptation in Hibernating American Black Bears: Exploring Immobilization Protection with Mass Spectral Data and Computational Methods

Anderson, M., Lusczek, B., Murray, K., Lassen, J. F., Ikramuddin, S. & Iles, T. L., 2023, Proceedings of the Future Technologies Conference (FTC) 2023, Volume 2. Arai, K. (ed.). Springer Science and Business Media Deutschland GmbH, p. 152-167 16 p. (Lecture Notes in Networks and Systems; vol. 814 LNNS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Perspectives on Heart Valve Modelling: Contexts of Use, Risk, Validation, Verification and Uncertainty Quantification and End-to-End Example

Veigh, C. M., Harewood, F., King, P., Driscoll, M., Kulkarni, S., Zhao, T., Goodin, M. & Iles, T. L., Jan 1 2023, Heart Valves: From Design to Clinical Implantation. Springer Science+Business Media, p. 457-486 30 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models

Gonzalez-Martin, P., Sacco, F., Butakoff, C., Doste, R., Bederian, C., Gutierrez Espinosa de los Monteros, L. K., Houzeaux, G., Iaizzo, P. A., Iles, T. L., Vazquez, M. & Aguado-Sierra, J., Feb 2023, In: PloS one. 18, 2 February, e0263639.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2022

ABERRANT CORONARY ARTERY: A RARE CONGENITAL ANOMALY EXAMINED THROUGH PRE- AND POST-PROCEDURAL 3D ANATOMICAL MODELING

Tenhoff, A. C., Iles, T. L., Iaizzo, P. A. & MacIver, R. H., 2022, Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, V001T02A007. (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

A Helpful Relocation Function for Augmenting Teaching in a Multiple User Shared Virtual Environment

Deakyne, A., Iles, T. L. & Iaizzo, P. A., 2022, Proceedings of the Future Technologies Conference, FTC 2021, Volume 3. Arai, K. (ed.). Springer Science and Business Media Deutschland GmbH, p. 377-386 10 p. (Lecture Notes in Networks and Systems; vol. 360 LNNS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Concomitant Respiratory Failure Can Impair Myocardial Oxygenation in Patients with Acute Cardiogenic Shock Supported by VA-ECMO

Prisco, A. R., Aguado-Sierra, J., Butakoff, C., Vazquez, M., Houzeaux, G., Eguzkitza, B., Bartos, J. A., Yannopoulos, D., Raveendran, G., Holm, M., Iles, T., Mahr, C. & Iaizzo, P. A., Apr 2022, In: Journal of cardiovascular translational research. 15, 2, p. 217-226 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

From Theoretical Network to Bedside: Translational Application of Brain-Inspired Computing in Clinical Medicine

Iles, T. L., Jun 1 2022, In: Applied Sciences (Switzerland). 12, 12, 5788.

Research output: Contribution to journal › Article › peer-review

Open Access

High-resolution 3D reconstructions of human vasculatures: creation of educational tools and benchtop models for transcatheter devices

Holm, M. A., Emfield, K., Iles, T. L. & Iaizzo, P. A., Jul 2022, In: Cardiovascular Intervention and Therapeutics. 37, 3, p. 519-525 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Treatment of coronary bifurcation lesions, part II: implanting two stents. The 16^th expert consensus document of the European Bifurcation Club

Lassen, J. F., Albiero, R., Johnson, T. W., Burzotta, F., Lefèvre, T., Iles, T. L., Pan, M., Banning, A. P., Chatzizisis, Y. S., Ferenc, M., Dzavik, V., Milasinovic, D., Darremont, O., Hildick-Smith, D., Louvard, Y. & Stankovic, G., Aug 2022, In: EuroIntervention. 18, 6, p. 457-470 14 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

2021

An engineering perspective on the development and evolution of implantable cardiac monitors in free-living animals

Laske, T. G., Garshelis, D. L., Iles, T. L. & Iaizzo, P. A., Aug 2 2021, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 376, 1830, 20200217.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Applications of computational simulation in bifurcation stenting: Past, present and future

Lassen, J. F. & Iles, T. L., 2021, In: EuroIntervention. 16, 9, p. E698-E700

Research output: Contribution to journal › Review article › peer-review

Assessing the complexity of human ventricular anatomy: Computational placement of mapping catheters in perfusion-fixed human hearts

Brigham, R. C., Gasser, R. L., Iles, T. L. & Iaizzo, P. A., 2021, Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021. American Society of Mechanical Engineers, V001T02A008. (Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Assessment of single and double coronary bifurcation stenting techniques using multimodal imaging and 3D modeling in reanimated swine hearts using Visible Heart® methodologies

Valenzuela, T. F., Burzotta, F., Iles, T. L., Lassen, J. F. & Iaizzo, P. A., Sep 2021, In: International Journal of Cardiovascular Imaging. 37, 9, p. 2591-2601 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Direct Visualization of TAVR-Related Coronary Artery Management Techniques in Reanimated Beating Hearts

Sanchez, J. Z., Burzotta, F., Valenzuela, T., Lassen, J. F., Iles, T. & Iaizzo, P. A., May 10 2021, In: JACC: Cardiovascular Interventions. 14, 9, p. e87-e91

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Enhancing mimetic three-dimensional modeling and printing for presurgical planning applications: Improved soft tissue assesments, analyses and consolidation strategies

Vergen, J. A., Iles, T. L. & Iaizzo, P. A., 2021, Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021. American Society of Mechanical Engineers, V001T01A001. (Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Interactive 3D Human Heart Simulations on Segmented Human MRI Hearts

Berman, J. P., Kaboudian, A., Uzelac, I., Iravanian, S., Iles, T., Iaizzo, P. A., Lim, H., Smolka, S., Glimm, J., Cherry, E. M. & Fenton, F. H., 2021, 2021 Computing in Cardiology, CinC 2021. IEEE Computer Society, (Computing in Cardiology; vol. 2021-September).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Neuromorphic representation of cardiac data from the American black bear during hibernation

Iles, T. L., Laske, T. G., Iaizzo, P. A. & Tsur, E. E., 2021, Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021. American Society of Mechanical Engineers, V001T09A002. (Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Patient-specific three-dimensional computational heart modeling and printing to enhance clinical understandings and treatment planning: Congenital recurrent pulmonary artery stenosis and transcatheter pulmonary valve replacement

Tenhoff, A. C., Aggarwal, V., Ameduri, R., Deakyne, A., Iles, T. L., Said, S. M., Griselli, M. & Iaizzo, P. A., 2021, Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021. American Society of Mechanical Engineers, V001T01A004. (Proceedings of the 2021 Design of Medical Devices Conference, DMD 2021).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Stepwise visualisation of a provisional bifurcation stenting procedure - Multimodal visualisation within a reanimated human heart utilising visible heart methodologies

Iles, T. L., Burzotta, F., Iaizzo, P. A. & Lassen, J. F., 2021, In: EuroIntervention. 16, 9, p. E734-E737

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Virtual Reality and Visualization of 3D Reconstructed Medical Imaging: Learning Variations Within Detailed Human Anatomies

Gaasedelen, E. N., Deakyne, A., Mattson, A. R., Mattison, L. M., Holm, M. A., Sanchez, J. D. Z., Schmidt, M. M., Bateman, M. G., Iles, T. L. & Iaizzo, P. A., 2021, Proceedings of the Future Technologies Conference, FTC 2020, Volume 3. Arai, K., Kapoor, S. & Bhatia, R. (eds.). Springer Science and Business Media Deutschland GmbH, p. 217-227 11 p. (Advances in Intelligent Systems and Computing; vol. 1290).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

2020

Algorithm for the analysis of pre-extraction computed tomographic images to evaluate implanted lead–lead interactions and lead–vascular attachments

Holm, M. A., Vatterott, P. J., Gaasedelen, E. N., Syed, I., Khan, A., Iles, T. L. & Iaizzo, P. A., Jun 2020, In: Heart Rhythm. 17, 6, p. 1009-1016 8 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Cardiac patient–specific three-dimensional models as surgical planning tools

Bateman, M. G., Durfee, W. K., Iles, T. L., Martin, C. M., Liao, K., Erdman, A. G. & Iaizzo, P. A., Feb 2020, In: Surgery (United States). 167, 2, p. 259-263 5 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Development of anaglyph 3D functionality for cost-effective virtual reality anatomical education tool

Deakyne, A. J., Gaasedelen, E., Iles, T. & Iaizzo, P. A., 2020, Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Development of an open-access library of pediatric congenital heart diseases and treatments: A tutorial on the atlas of human cardiac anatomy

Tenhoff, A. C., Deakyne, A. J., Iles, T. L., Narasimhan, S. L., Said, S. M., Griselli, M. & Iaizzo, P. A., 2020, Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Direct visualisation of the BASILICA technique post TAVR to enhance coronary flow

Sanchez, J. D. Z., Iles, T. L., Dvir, D. & Iaizzo, P. A., 2020, In: EuroIntervention. 16, 8, p. 680-681 2 p.

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

First Successful Open-Heart Surgery Utilizing Cross-Circulation in 1954

Iles, T. L., Holm, M. A., Calvin, A. D., Moller, J. H. & Iaizzo, P. A., Jul 2020, In: Annals of Thoracic Surgery. 110, 1, p. 336-341 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study

Gonzalez, A., Iles, T. L., Iaizzo, P. A. & Bandschapp, O., Dec 1 2020, In: BMC Anesthesiology. 20, 1, 270.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Lung allocation pipeline: Machine learning approach to optimized lung transplant

Schinstock, E., Deakyne, A., Iles, T., Shaffer, A. & Iaizzo, P. A., 2020, Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Merit of an ursodeoxycholic acid clinical trial in COVID-19 patients

Subramanian, S., Iles, T., Ikramuddin, S. & Steer, C. J., Jun 2020, In: Vaccines. 8, 2, p. 1-4 4 p., 320.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Multimodal functional and still imaging of a transplanted human heart reanimated using Visible Heart® methodologies

Bateman, M. G., Iles, T. L., Quallich, S. G., Shaffer, A. W. & Iaizzo, P. A., Mar 1 2020, In: Journal of Cardiac Surgery. 35, 3, p. 668-671 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Prolonged extracorporeal preservation and evaluation of human lungs with portable normothermic ex vivo perfusion

Spratt, J. R., Mattison, L. M., Kerns, N. K., Huddleston, S. J., Meyer, L., Iles, T. L., Loor, G. & Iaizzo, P. A., Mar 1 2020, In: Clinical Transplantation. 34, 3, e13801.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

The noninvasive electrical mapping of reanimated large mammalian hearts

Brigham, R. C., Ramirez, D. A., Iles, T. L. & Iaizzo, P. A., 2020, Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

The significant other: Evaluation of side branch ostial compromise in bifurcation stenting

Iles, T. L., Stankovic, G. & Lassen, J. F., 2020, In: Cardiology Journal. 27, 5, p. 474-477 4 p.

Research output: Contribution to journal › Editorial › peer-review

Using computational modeling derived from micro CT scanning for the post-implant analyses of various cardiac devices

Valenzuela, T., Sanchez, J. Z., Holm, M., Iles, T. & Iaizzo, P., 2020, Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2020 Design of Medical Devices Conference, DMD 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Virtual prototyping: Computational device placements within detailed human heart models

Deakyne, A. J., Iles, T. L., Mattson, A. R. & Iaizzo, P. A., Jan 1 2020, In: Applied Sciences (Switzerland). 10, 1, 175.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2019

Effects of ATP administration on isolated swine hearts: Implications for ex vivo perfusion and cardiac transplantation

Seewald, M. S., Gaasedelen, E. N., Iles, T. L., Mattison, L. M., Mattson, A. R., Schmidt, M. M., Braun-Dullaeus, R. C. & Iaizzo, P. A., Aug 1 2019, In: Experimental Biology and Medicine. 244, 11, p. 915-922 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Identification of Radiofrequency Ablation Catheter Parameters That May Induce Intracardiac Steam Pops: Direct Visualization of Elicitation in Reanimated Swine Hearts

Iles, T. L., Quallich, S. G. & Iaizzo, P. A., Jun 15 2019, In: Journal of cardiovascular translational research. 12, 3, p. 250-256 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Simulating blood flow in healthy swine coronary arteries after bifurcation stenting procedures

Valenzuela, T., Bateman, M., Iles, T. & Iaizzo, P. A., 2019, Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

The use of 3D printing in the surgical planning of left ventricular assist device placement in pediatric patients with non-compaction

Bateman, M. G., Iles, T. L., Jang, S., Iaizzo, P. A. & Griselli, M., Jan 1 2019, Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019. American Society of Mechanical Engineers (ASME), (Frontiers in Biomedical Devices, BIOMED - 2019 Design of Medical Devices Conference, DMD 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

2018

Advancing the design and testing of novel cardiac device technologies using the visible heart

Bateman, M. G., Iles, T. L. & Iaizzo, P. A., Jan 1 2018, Engineering in Medicine: Advances and Challenges. Elsevier, p. 119-152 34 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

A new era for improving cardiothoracic transplantations

Shaffer, A. W., Mattison, L. M., Spratt, J. R., Iles, T. L., Kerns, N., Bateman, M. G., Huddleston, S. J., Kelly, R. F., John, R., Liao, K. K. & Iaizzo, P. A., Jan 1 2018, Engineering in Medicine: Advances and Challenges. Elsevier, p. 55-82 28 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Development and utilization of implantable cardiac monitors in free-ranging American black and Eurasian brown bears: System evolution and lessons learned

Laske, T. G., Evans, A. L., Arnemo, J. M., Iles, T. L., Ditmer, M. A., Fröbert, O., Garshelis, D. L. & Iaizzo, P. A., Sep 29 2018, In: Animal Biotelemetry. 6, 1, 13.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

Evaluating the roles of detailed endocardial structures on right ventricular haemodynamics by means of CFD simulations

Sacco, F., Paun, B., Lehmkuhl, O., Iles, T. L., Iaizzo, P. A., Houzeaux, G., Vázquez, M., Butakoff, C. & Aguado-Sierra, J., Sep 2018, In: International Journal for Numerical Methods in Biomedical Engineering. 34, 9, e3115.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Investigating the physiological effects of 10.5 Tesla static field exposure on anesthetized swine

Eryaman, Y., Zhang, P., Utecht, L., Kose, K., Lagore, R. L., Delabarre, L., Kulesa, J., Eberly, L. E., Adriany, G., Iles, T. L., Iaizzo, P. A., Vaughan, J. T. & Ugurbil, K., Jan 2018, In: Magnetic resonance in medicine. 79, 1, p. 511-514 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Left ventricular trabeculations decrease the wall shear stress and increase the intra-ventricular pressure drop in CFD simulations

Sacco, F., Paun, B., Lehmkuhl, O., Iles, T. L., Iaizzo, P. A., Houzeaux, G., Vázquez, M., Butakoff, C. & Aguado-Sierra, J., Apr 30 2018, In: Frontiers in Physiology. 9, 458.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Lung transplant after prolonged ex vivo lung perfusion: predictors of allograft function in swine

Spratt, J. R., Mattison, L. M., Iaizzo, P. A., Meyer, C., Brown, R. Z., Iles, T., Panoskaltsis-Mortari, A. & Loor, G., Dec 2018, In: Transplant International. 31, 12, p. 1405-1417 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2017

An experimental study of the recovery of injured porcine lungs with prolonged normothermic cellular ex vivo lung perfusion following donation after circulatory death

Spratt, J. R., Mattison, L. M., Iaizzo, P. A., Brown, R. Z., Helms, H., Iles, T. L., Howard, B., Panoskaltsis-Mortari, A. & Loor, G., Sep 2017, In: Transplant International. 30, 9, p. 932-944 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Blood clotting behavior is innately modulated in Ursus Americanus during early and late denning relative to summer months

Iles, T. L., Laske, T. G., Garshelis, D. L. & Iaizzo, P. A., Feb 1 2017, In: Journal of Experimental Biology. 220, 3, p. 455-459 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Tinen L Iles

Research output

Search results