Human β‐endorphin (βh‐EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, βh‐EP is 24 times more potent than morphine. Intraventricularly, βh‐EP is 24 times more potent than morphine. Intraventricularly, βh‐EP is effective at doses (0.45 μg) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of βh‐endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of βh‐endorphin.
|Original language||English (US)|
|Number of pages||4|
|Journal||International Journal of Peptide and Protein Research|
|State||Published - Sep 1978|
- antidiuretic action