β               h‐ENDORPHIN: ANTIDIURETIC EFFECTS IN RATS

Liang‐Fu ‐F Tseng; Horace H. Loh; Choh Hao Li

doi:10.1111/j.1399-3011.1978.tb02882.x

β _h‐ENDORPHIN: ANTIDIURETIC EFFECTS IN RATS

Liang‐Fu ‐F Tseng, Horace H. Loh, Choh Hao Li

Pharmacology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Human β‐endorphin (β_h‐EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, β_h‐EP is 24 times more potent than morphine. Intraventricularly, β_h‐EP is 24 times more potent than morphine. Intraventricularly, β_h‐EP is effective at doses (0.45 μg) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of β_h‐endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of β_h‐endorphin.

Original language	English (US)
Pages (from-to)	173-176
Number of pages	4
Journal	International Journal of Peptide and Protein Research
Volume	12
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-3011.1978.tb02882.x
State	Published - Sep 1978

Keywords

antidiuretic action
β‐endorphin

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title = "β h‐ENDORPHIN: ANTIDIURETIC EFFECTS IN RATS",

abstract = "Human β‐endorphin (βh‐EP) inhibits urine flow in rats. This antidiuretic effect of the peptide occurs after intravenous and intraventricular injections. Intravenously, βh‐EP is 24 times more potent than morphine. Intraventricularly, βh‐EP is 24 times more potent than morphine. Intraventricularly, βh‐EP is effective at doses (0.45 μg) which have no antidiuretic activity when injected intravenously. This fact suggests that one site of the antidiuretic action of βh‐endorphin may be in the central nervous system. Animals tolerant to morphine are also tolerant to the antidiuretic effects of βh‐endorphin.",

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