μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality

Horace H Loh, Hsien Ching Liu, Antonella Cavalli, Wanling Yang, Yuh Fung Chen, Li-Na Wei

Research output: Contribution to journalArticlepeer-review

286 Scopus citations

Abstract

The μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of μ-specific opioid ligands and acute morphine lethality are mediated by the μ receptor.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalMolecular Brain Research
Volume54
Issue number2
DOIs
StatePublished - Mar 1 1998

Keywords

  • Gene-targeting
  • Morphine analgesia
  • Morphine lethality
  • μ opioid receptor

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