Abstract
The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function. In addition, we show that neither S nor K receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (±) and wild type (+/+) animals.
Original language | English (US) |
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Pages (from-to) | 281-283 |
Number of pages | 3 |
Journal | Molecular Brain Research |
Volume | 56 |
Issue number | 1-2 |
DOIs | |
State | Published - May 1998 |
Bibliographical note
Funding Information:This work was supported by NIH grants DA00564, DA01583, DA05695, K05-DA70554, F. and A. Stark Fund (MMF)-HHL and DA08188 (SR).
Keywords
- Gastrointestinal motility
- Knockout
- Morphine
- μ-Opioid receptor