15-methylation augments the cardiovascular effects of prostaglandin F

E. K. Weir, J. T. Reeves, W. Droegemueller, R. F. Grover

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Intramuscular injection of the 15-methyl analogue of prostaglandin F (15-me-PGF) is being used to initiate second trimester abortion. The natural prostaglandin F (PGF) is a known pulmonary pressor agent but there is little information about the cardiovascular effects of the analogue. Consequently, we compared the hemodynamic responses to the two forms in twenty-three anesthetized dogs. Given I.M. or I.V. 15-me-PGF produced a greater and more sustained rise in pulmonary arterial pressure than PG F. Intramuscular 15-me-PGF also elicited a more prolonged increase in pulmonary vascular resistance than prostaglandin F given I.M. or I.V. The methyl analogue (I.M. or I.V.) causes a greater initial fall in systemic arterial oxygen tension and cardiac output, and a greater increase in systemic resistance than I.M. PG F Breathlessness seen during abortion induced by prostaglandin F or its methyl analogue may be caused by acute pulmonary hypertension in addition to bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalProstaglandins
Volume9
Issue number3
DOIs
StatePublished - Mar 1975

Bibliographical note

Funding Information:
This work was supported by grants #HL 14985 and HL 05973 from the National Institutes of Health, and a generous grant from the Upjohn Company, Kalamazoo, Michigan. Dr. Weir is the recipient of a Fulbright scolarship. Dr. Grover is the recipient of an NIH Research Career Development Award, #HL 29237. We are grateful for the assistance of R. Glas, B. Kaplan, M. Munroe, D. Smith, E. Toyos, S. Hofmeister and D. Jackson. We would like to thank Dr. G.O. Zerbe for statistical advice. Prostaglandins F2e and methyl F2e were kindly provided by the Upjohn Company.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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