2-Aza-1,3-dienes, prepared in excellent yields from aldehydes and readily available allylamine, were utilized to synthesize N-(1-propenyl)-β-lactams. Oxidative cleavage of the N-protecting group produced N-unsubstituted β-lactams. 4-Acetoxy-3-phenoxy-2-azetidinone was synthesized in three steps and 34% overall yield.
Bibliographical noteFunding Information:
ACkUX#leageoents: Financial assistance fran the National Institutes of The American Heart Association of Kansas (KS-87-G-17) and the Bianedical 5606) at the University of Kansas is acknowledged.