3,5,7,3′,4′-Pentamethoxyflavone, a quercetin derivative protects DNA from oxidative challenges: Potential mechanism of action

Rekha Jakhar, Souren Paul, Young Rong Park, Jaehong Han, Sun Chul Kang

Research output: Contribution to journalArticlepeer-review

Abstract

DNA protection is one of the most important strategies in cancer therapy. Since quercetin and its derivatives are found to be potent antioxidant agents, they are able to scavenge radicals significantly. Therefore, we focused on the DNA protection activity of 3,5,7,3′,4′-pentamethoxyflavone (PMF), a quercetin derivative isolated from Kaemperia parviflora. Although, PMF was found to be a very poor antioxidant compound, still it could remarkably protect DNA from oxidative damage. DNA binding assay showed that PMF bound to the minor groove of DNA, which suggests a possible mechanism for its DNA protective effects. Cellular toxicity assay on RAW 264.7 macrophages showed this compound is very safe for therapeutic applications.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalJournal of Photochemistry and Photobiology B: Biology
Volume131
DOIs
StatePublished - Feb 5 2014
Externally publishedYes

Keywords

  • Antioxidant
  • Comet assay
  • DNA binding
  • DNA damage
  • ROS

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