4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Apurba Datta; Lalith R. Jayasinghe; Gunda I. Georg

doi:10.1021/jm00050a023

4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Apurba Datta, Lalith R. Jayasinghe, Gunda I. Georg

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.

Original language	English (US)
Pages (from-to)	4258-4260
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	37
Issue number	24
DOIs	https://doi.org/10.1021/jm00050a023
State	Published - Nov 1 1994

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title = "4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation",

abstract = "4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.",

author = "Apurba Datta and Jayasinghe, {Lalith R.} and Georg, {Gunda I.}",

year = "1994",

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T1 - 4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere

T2 - Synthesis and Biological Evaluation

AU - Datta, Apurba

AU - Jayasinghe, Lalith R.

AU - Georg, Gunda I.

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AB - 4-Deacetyltaxol and 10-acetyl-4-deacetyltaxotere were synthesized for the first time from 7-(triethylsilyl)-4-deacetylbaccatin III. These analogs were found to be inactive in the microtubule assembly assay.

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4-Deacetyltaxol and 10-Acetyl-4-deacetyltaxotere: Synthesis and Biological Evaluation

Abstract

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