4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Frederik J.G.M. Van Kuijk; Laura L. Holte; Edward A. Dratz

doi:10.1016/0005-2760(90)90118-H

4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Frederik J.G.M. Van Kuijk, Laura L. Holte, Edward A. Dratz

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	1043
Issue number	1
DOIs	https://doi.org/10.1016/0005-2760(90)90118-H
State	Published - Mar 12 1990

Bibliographical note

Funding Information:
This work was supported by a grant from the Niels Stensen Foundation (The Netherlands) (to F.J.G.M. v.K.) and by grant No. ROl-EY06913 from the USA National Eye Institute (to E.A.D.).

Keywords

4-Hydroxyhexenal
4-Hydroxynonenal
Docosahexaenoic acid
Lipid peroxidation

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title = "4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid",

abstract = "4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.",

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note = "Funding Information: This work was supported by a grant from the Niels Stensen Foundation (The Netherlands) (to F.J.G.M. v.K.) and by grant No. ROl-EY06913 from the USA National Eye Institute (to E.A.D.).",

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AU - Holte, Laura L.

AU - Dratz, Edward A.

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N2 - 4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

AB - 4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n-6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.

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4-Hydroxyhexenal: A lipid peroxidation product derived from oxidized docosahexaenoic acid

Abstract

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Keywords

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