9.4T human MRI: Preliminary results

Thomas Vaughan, Lance DelaBarre, Cari Snyder, Jinfeng Tian, Can Akgun, Devashish Shrivastava, Wanzahn Liu, Chris Olson, Gregor Adriany, John Strupp, Peter Andersen, Anand Gopinath, Pierre Francois Van De Moortele, Michael Garwood, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9.4T head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9.4T.

Original languageEnglish (US)
Pages (from-to)1274-1282
Number of pages9
JournalMagnetic resonance in medicine
Volume56
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • 9.4T human MRI
  • B shimming
  • High field MRI
  • Multi-channel transmit

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