A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

Adam E. Mendrela; Jihyun Cho; Jeffrey A. Fredenburg; Vivek Nagaraj; Tay I Netoff; Michael P. Flynn; Euisik Yoon

doi:10.1109/JSSC.2015.2506651

A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

Adam E. Mendrela, Jihyun Cho, Jeffrey A. Fredenburg, Vivek Nagaraj, Tay I Netoff, Michael P. Flynn, Euisik Yoon

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

This work presents a bidirectional neural interface circuit that enables simultaneous recording and stimulation with a stimulation artifact cancellation circuit. The system employs a common average referencing (CAR) front-end circuit to suppress cross-channel environmental noise to further facilitate use in clinical environment. This paper also introduces a new range-adapting (RA) SAR ADC to lower the system power consumption. A prototype is fabricated in 0.18 μm CMOS and characterized and tested in vivo in an epileptic rat model. The prototype attenuates stimulation artifacts by up to 42 dB and suppresses cross-channel noise by up to 39.8 dB. The measured power consumption per channel is 330 nW, while the area per channel is 0.17 mm².

Original language	English (US)
Article number	7370773
Pages (from-to)	955-965
Number of pages	11
Journal	IEEE Journal of Solid-State Circuits
Volume	51
Issue number	4
DOIs	https://doi.org/10.1109/JSSC.2015.2506651
State	Published - Apr 2016

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

Closed-loop stimulation
SAR ADC
low power
neural recording
noise cancellation

Access

10.1109/JSSC.2015.2506651

OpenUrl availability

Full text

Cite this

@article{efa17cdc633a42b3b1a3d7121c9228e0,

title = "A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression",

abstract = "This work presents a bidirectional neural interface circuit that enables simultaneous recording and stimulation with a stimulation artifact cancellation circuit. The system employs a common average referencing (CAR) front-end circuit to suppress cross-channel environmental noise to further facilitate use in clinical environment. This paper also introduces a new range-adapting (RA) SAR ADC to lower the system power consumption. A prototype is fabricated in 0.18 μm CMOS and characterized and tested in vivo in an epileptic rat model. The prototype attenuates stimulation artifacts by up to 42 dB and suppresses cross-channel noise by up to 39.8 dB. The measured power consumption per channel is 330 nW, while the area per channel is 0.17 mm2.",

keywords = "Closed-loop stimulation, SAR ADC, low power, neural recording, noise cancellation",

author = "Mendrela, {Adam E.} and Jihyun Cho and Fredenburg, {Jeffrey A.} and Vivek Nagaraj and Netoff, {Tay I} and Flynn, {Michael P.} and Euisik Yoon",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.",

year = "2016",

month = apr,

doi = "10.1109/JSSC.2015.2506651",

language = "English (US)",

volume = "51",

pages = "955--965",

journal = "IEEE Journal of Solid-State Circuits",

issn = "0018-9200",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "4",

}

TY - JOUR

T1 - A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

AU - Mendrela, Adam E.

AU - Cho, Jihyun

AU - Fredenburg, Jeffrey A.

AU - Nagaraj, Vivek

AU - Netoff, Tay I

AU - Flynn, Michael P.

AU - Yoon, Euisik

PY - 2016/4

Y1 - 2016/4

N2 - This work presents a bidirectional neural interface circuit that enables simultaneous recording and stimulation with a stimulation artifact cancellation circuit. The system employs a common average referencing (CAR) front-end circuit to suppress cross-channel environmental noise to further facilitate use in clinical environment. This paper also introduces a new range-adapting (RA) SAR ADC to lower the system power consumption. A prototype is fabricated in 0.18 μm CMOS and characterized and tested in vivo in an epileptic rat model. The prototype attenuates stimulation artifacts by up to 42 dB and suppresses cross-channel noise by up to 39.8 dB. The measured power consumption per channel is 330 nW, while the area per channel is 0.17 mm2.

AB - This work presents a bidirectional neural interface circuit that enables simultaneous recording and stimulation with a stimulation artifact cancellation circuit. The system employs a common average referencing (CAR) front-end circuit to suppress cross-channel environmental noise to further facilitate use in clinical environment. This paper also introduces a new range-adapting (RA) SAR ADC to lower the system power consumption. A prototype is fabricated in 0.18 μm CMOS and characterized and tested in vivo in an epileptic rat model. The prototype attenuates stimulation artifacts by up to 42 dB and suppresses cross-channel noise by up to 39.8 dB. The measured power consumption per channel is 330 nW, while the area per channel is 0.17 mm2.

KW - Closed-loop stimulation

KW - SAR ADC

KW - low power

KW - neural recording

KW - noise cancellation

UR - http://www.scopus.com/inward/record.url?scp=84953298502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953298502&partnerID=8YFLogxK

U2 - 10.1109/JSSC.2015.2506651

DO - 10.1109/JSSC.2015.2506651

M3 - Article

AN - SCOPUS:84953298502

SN - 0018-9200

VL - 51

SP - 955

EP - 965

JO - IEEE Journal of Solid-State Circuits

JF - IEEE Journal of Solid-State Circuits

IS - 4

M1 - 7370773

ER -

A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this