A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients

Nelson L. Rhodus; Bin Cheng; Sandra Myers; Walter Bowles; Vu Ho; Frank Ondrey

doi:10.1016/j.clim.2004.12.003

A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients

Nelson L. Rhodus, Bin Cheng, Sandra Myers, Walter Bowles, Vu Ho, Frank Ondrey

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

To explore the feasibility of detection of the level of NF-κB-dependent cytokines in oral fluids from patient with oral lichen planus (OLP) for clinical application, 13 OLP subjects were enrolled in the study as were 13 age-sex-matched controls. In each subject, the whole unstimulated saliva (WUS), mixture of saliva and isotonic saline oral rinse (Saliva-NaCl), and lesion tissue transudates (TT) were collected by standard techniques. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids was determined by ELISA. In the three types of oral fluids, a significantly higher level of these cytokines was detected in OLP patients than in normal controls. These results indicate that NF-κB-dependent inflammatory cytokines may be detected at increased levels in certain oral fluids which may have diagnostic and prognostic potential for monitoring disease activity and making therapeutic decisions in patients with OLP.

Original language	English (US)
Pages (from-to)	278-283
Number of pages	6
Journal	Clinical Immunology
Volume	114
Issue number	3 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.clim.2004.12.003
State	Published - Mar 2005

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Natural Scientific Foundation of China (30371539). The authors wish to thank Dr. Y.L. Huang and X.B. Chen from Guanghua School of Stomatology, Sun Yat-sen University, P.R. China, for statistical analysis.

Keywords

NF-κB-dependent cytokines
Oral fluids
Oral lichen planus
Saliva

Access

10.1016/j.clim.2004.12.003

OpenUrl availability

Full text

Cite this

@article{9d4a52eaf1944b22988b480465a6ef1d,

title = "A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients",

abstract = "To explore the feasibility of detection of the level of NF-κB-dependent cytokines in oral fluids from patient with oral lichen planus (OLP) for clinical application, 13 OLP subjects were enrolled in the study as were 13 age-sex-matched controls. In each subject, the whole unstimulated saliva (WUS), mixture of saliva and isotonic saline oral rinse (Saliva-NaCl), and lesion tissue transudates (TT) were collected by standard techniques. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids was determined by ELISA. In the three types of oral fluids, a significantly higher level of these cytokines was detected in OLP patients than in normal controls. These results indicate that NF-κB-dependent inflammatory cytokines may be detected at increased levels in certain oral fluids which may have diagnostic and prognostic potential for monitoring disease activity and making therapeutic decisions in patients with OLP.",

keywords = "NF-κB-dependent cytokines, Oral fluids, Oral lichen planus, Saliva",

author = "Rhodus, {Nelson L.} and Bin Cheng and Sandra Myers and Walter Bowles and Vu Ho and Frank Ondrey",

note = "Funding Information: This work was supported in part by grants from the National Natural Scientific Foundation of China (30371539). The authors wish to thank Dr. Y.L. Huang and X.B. Chen from Guanghua School of Stomatology, Sun Yat-sen University, P.R. China, for statistical analysis.",

year = "2005",

month = mar,

doi = "10.1016/j.clim.2004.12.003",

language = "English (US)",

volume = "114",

pages = "278--283",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "3 SPEC. ISS.",

}

TY - JOUR

T1 - A comparison of the pro-inflammatory, NF-κB-dependent cytokines

T2 - TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients

AU - Rhodus, Nelson L.

AU - Cheng, Bin

AU - Myers, Sandra

AU - Bowles, Walter

AU - Ho, Vu

AU - Ondrey, Frank

N1 - Funding Information: This work was supported in part by grants from the National Natural Scientific Foundation of China (30371539). The authors wish to thank Dr. Y.L. Huang and X.B. Chen from Guanghua School of Stomatology, Sun Yat-sen University, P.R. China, for statistical analysis.

PY - 2005/3

Y1 - 2005/3

N2 - To explore the feasibility of detection of the level of NF-κB-dependent cytokines in oral fluids from patient with oral lichen planus (OLP) for clinical application, 13 OLP subjects were enrolled in the study as were 13 age-sex-matched controls. In each subject, the whole unstimulated saliva (WUS), mixture of saliva and isotonic saline oral rinse (Saliva-NaCl), and lesion tissue transudates (TT) were collected by standard techniques. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids was determined by ELISA. In the three types of oral fluids, a significantly higher level of these cytokines was detected in OLP patients than in normal controls. These results indicate that NF-κB-dependent inflammatory cytokines may be detected at increased levels in certain oral fluids which may have diagnostic and prognostic potential for monitoring disease activity and making therapeutic decisions in patients with OLP.

AB - To explore the feasibility of detection of the level of NF-κB-dependent cytokines in oral fluids from patient with oral lichen planus (OLP) for clinical application, 13 OLP subjects were enrolled in the study as were 13 age-sex-matched controls. In each subject, the whole unstimulated saliva (WUS), mixture of saliva and isotonic saline oral rinse (Saliva-NaCl), and lesion tissue transudates (TT) were collected by standard techniques. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids was determined by ELISA. In the three types of oral fluids, a significantly higher level of these cytokines was detected in OLP patients than in normal controls. These results indicate that NF-κB-dependent inflammatory cytokines may be detected at increased levels in certain oral fluids which may have diagnostic and prognostic potential for monitoring disease activity and making therapeutic decisions in patients with OLP.

KW - NF-κB-dependent cytokines

KW - Oral fluids

KW - Oral lichen planus

KW - Saliva

UR - http://www.scopus.com/inward/record.url?scp=13944269508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13944269508&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2004.12.003

DO - 10.1016/j.clim.2004.12.003

M3 - Article

C2 - 15721838

AN - SCOPUS:13944269508

SN - 1521-6616

VL - 114

SP - 278

EP - 283

JO - Clinical Immunology

JF - Clinical Immunology

IS - 3 SPEC. ISS.

ER -

A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this