TY - GEN
T1 - A conserved role for myosin VII in adhesion
AU - Titus, Margaret A.
PY - 2005/12/1
Y1 - 2005/12/1
N2 - The class VII myosins (M7) are expressed in a wide range of organisms. M7 mutants in mice, zebrafish and Dictyostelium exhibit phenotypes that reveal a role for M7 in adhesion in these highly divergent systems, suggesting a basic conservation of M7 function throughout evolution. M7s are characterized by the presence of two FERM domains in their C-terminal tail region, and deletion of either from the Dictyostelium M7 (DdM7) tail results in loss of function without affecting localization. A search for DdM7 binding partners has revealed that talin, an actin-binding protein that provides a key link between adhesion receptors and the actin cytoskeleton, interacts directly with DdM7. The phenotypes of the DdM7 and talin null mutants are highly similar, suggesting that these two proteins work co-operatively to maintain cell-cell and cell-surface contact and that this interaction may also be conserved throughout evolution.
AB - The class VII myosins (M7) are expressed in a wide range of organisms. M7 mutants in mice, zebrafish and Dictyostelium exhibit phenotypes that reveal a role for M7 in adhesion in these highly divergent systems, suggesting a basic conservation of M7 function throughout evolution. M7s are characterized by the presence of two FERM domains in their C-terminal tail region, and deletion of either from the Dictyostelium M7 (DdM7) tail results in loss of function without affecting localization. A search for DdM7 binding partners has revealed that talin, an actin-binding protein that provides a key link between adhesion receptors and the actin cytoskeleton, interacts directly with DdM7. The phenotypes of the DdM7 and talin null mutants are highly similar, suggesting that these two proteins work co-operatively to maintain cell-cell and cell-surface contact and that this interaction may also be conserved throughout evolution.
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M3 - Conference contribution
C2 - 16355532
AN - SCOPUS:33644801513
SN - 9780470011904
T3 - Novartis Foundation Symposium
SP - 16
EP - 24
BT - Signalling Networks in Cell Shape and Motility
ER -