A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides

Michael O. Frederick, Jason A. Mulder, Michael R. Tracey, Richard P. Hsung, Jian Huang, Kimberly C.M. Kurtz, Lichun Shen, Christopher J. Douglas

Research output: Contribution to journalArticlepeer-review

205 Scopus citations

Abstract

A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides.

Original languageEnglish (US)
Pages (from-to)2368-2369
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number9
DOIs
StatePublished - Mar 5 2003

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