A facile solid phase synthesis of 2-alkylthio-4(1H)-quinolones

Jing Tang, Ming Guang Wu, Xian Huang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The resin-bound cyclic malonic acid ester 2 reacted with aryl isothiocyanate and alkyl halides to afford the key intermediate arylthioaminomethylene cyclic malonic ester resin 3. Subsequently, resin 3 proceeded thermal cydization giving the 2-alkylthio-4(1H)-quinolones in good yields and excellent purities.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalChinese Journal of Chemistry
Issue number5
StatePublished - May 1 2003


  • 2-alkylthio-4(1H)-quinolones
  • Resin-bound cyclic malonic acid ester
  • Solid-phase synthesis

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