Abstract
The preparation and spectroscopic characteristics of a novel coumarin derivative of α-bungarotoxin are described. The suitability of this fluorescent conjugate as a probe of cell surface topography and dynamics of acetylcholine receptors is discussed. Data are presented that show this coumarin-α-bungarotoxin conjugate to be an ideal donor fluorophore for time-resolved resonance energy transfer studies employing fluorescein as an acceptor.
Original language | English (US) |
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Pages (from-to) | 1112-1119 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 103 |
Issue number | 3 |
DOIs | |
State | Published - Dec 15 1981 |