A fluorescent coumarin derivative of α-bungarotoxin. Synthesis and spectroscopic characterization

B. A. Herman; S. M. Fernandez

doi:10.1016/0006-291X(81)90923-2

A fluorescent coumarin derivative of α-bungarotoxin. Synthesis and spectroscopic characterization

B. A. Herman, S. M. Fernandez

Biomedical Engineering

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Abstract

The preparation and spectroscopic characteristics of a novel coumarin derivative of α-bungarotoxin are described. The suitability of this fluorescent conjugate as a probe of cell surface topography and dynamics of acetylcholine receptors is discussed. Data are presented that show this coumarin-α-bungarotoxin conjugate to be an ideal donor fluorophore for time-resolved resonance energy transfer studies employing fluorescein as an acceptor.

Original language	English (US)
Pages (from-to)	1112-1119
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(81)90923-2
State	Published - Dec 15 1981

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abstract = "The preparation and spectroscopic characteristics of a novel coumarin derivative of α-bungarotoxin are described. The suitability of this fluorescent conjugate as a probe of cell surface topography and dynamics of acetylcholine receptors is discussed. Data are presented that show this coumarin-α-bungarotoxin conjugate to be an ideal donor fluorophore for time-resolved resonance energy transfer studies employing fluorescein as an acceptor.",

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A fluorescent coumarin derivative of α-bungarotoxin. Synthesis and spectroscopic characterization

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