A fully-aqueous red-fluorescent probe for selective optical sensing of Hg2+ and its application in living cells

Murali Krishna Pola; Mandapati V. Ramakrishnam Raju; Chein Ming Lin; Raghunath Putikam; Ming Chang Lin; Chandra Prakash Epperla; Huan Cheng Chang; San Yuan Chen; Hong Cheu Lin

doi:10.1016/j.dyepig.2016.03.028

A fully-aqueous red-fluorescent probe for selective optical sensing of Hg²⁺ and its application in living cells

Murali Krishna Pola, Mandapati V. Ramakrishnam Raju, Chein Ming Lin, Raghunath Putikam, Ming Chang Lin, Chandra Prakash Epperla, Huan Cheng Chang, San Yuan Chen, Hong Cheu Lin

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A new red-fluorescent mercury ion sensor material is designed and synthesized, which is composed of a tweezer-shaped hydrophilic probe containing bifurcated soft-base atoms N and S coupled with 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) unit. By virtue of the strong electron-accepting nature of TCF unit (as a push-pull chromophore), this designed sensor material can selectively detect Hg²⁺ over various tested metal ions in a 100% aqueous medium via naked-eye and photoluminescence (PL) observations. Theoretical and time-resolved photoluminescence measurements further confirmed the selectivity and reversibility of the probe towards Hg²⁺ via intramolocular charge transfer mechanism in this sensor material. Moreover, the living cell tests by confocal fluorescence images of this sensor material towards Hg²⁺ were also investigated. Finally, distinguished absorption changes and fluorescence quenching spectral appearances allowed us to present the selective optical indicator of Hg²⁺ via TCF moiety for the first time.

Original language	English (US)
Pages (from-to)	256-265
Number of pages	10
Journal	Dyes and Pigments
Volume	130
DOIs	https://doi.org/10.1016/j.dyepig.2016.03.028
State	Published - Jul 2016

Bibliographical note

Funding Information:
We thank the Ministry of Science and Technology (MOST) in Taiwan for the financial supports of this project through MOST 103-2113-M-009-018-MY3 and MOST 103-2221-E-009-215-MY3 .

Keywords

Aqueous medium
ICT
Living cell
Push-pull chromophore

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10.1016/j.dyepig.2016.03.028

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@article{cb86dfa6b15e494f934218ab20191467,

title = "A fully-aqueous red-fluorescent probe for selective optical sensing of Hg2+ and its application in living cells",

abstract = "A new red-fluorescent mercury ion sensor material is designed and synthesized, which is composed of a tweezer-shaped hydrophilic probe containing bifurcated soft-base atoms N and S coupled with 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) unit. By virtue of the strong electron-accepting nature of TCF unit (as a push-pull chromophore), this designed sensor material can selectively detect Hg2+ over various tested metal ions in a 100% aqueous medium via naked-eye and photoluminescence (PL) observations. Theoretical and time-resolved photoluminescence measurements further confirmed the selectivity and reversibility of the probe towards Hg2+ via intramolocular charge transfer mechanism in this sensor material. Moreover, the living cell tests by confocal fluorescence images of this sensor material towards Hg2+ were also investigated. Finally, distinguished absorption changes and fluorescence quenching spectral appearances allowed us to present the selective optical indicator of Hg2+ via TCF moiety for the first time.",

keywords = "Aqueous medium, ICT, Living cell, Push-pull chromophore",

author = "Pola, {Murali Krishna} and {Ramakrishnam Raju}, {Mandapati V.} and Lin, {Chein Ming} and Raghunath Putikam and Lin, {Ming Chang} and Epperla, {Chandra Prakash} and Chang, {Huan Cheng} and Chen, {San Yuan} and Lin, {Hong Cheu}",

note = "Funding Information: We thank the Ministry of Science and Technology (MOST) in Taiwan for the financial supports of this project through MOST 103-2113-M-009-018-MY3 and MOST 103-2221-E-009-215-MY3 . ",

year = "2016",

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doi = "10.1016/j.dyepig.2016.03.028",

language = "English (US)",

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T1 - A fully-aqueous red-fluorescent probe for selective optical sensing of Hg2+ and its application in living cells

AU - Pola, Murali Krishna

AU - Ramakrishnam Raju, Mandapati V.

AU - Lin, Chein Ming

AU - Putikam, Raghunath

AU - Lin, Ming Chang

AU - Epperla, Chandra Prakash

AU - Chang, Huan Cheng

AU - Chen, San Yuan

AU - Lin, Hong Cheu

N1 - Funding Information: We thank the Ministry of Science and Technology (MOST) in Taiwan for the financial supports of this project through MOST 103-2113-M-009-018-MY3 and MOST 103-2221-E-009-215-MY3 .

PY - 2016/7

Y1 - 2016/7

N2 - A new red-fluorescent mercury ion sensor material is designed and synthesized, which is composed of a tweezer-shaped hydrophilic probe containing bifurcated soft-base atoms N and S coupled with 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) unit. By virtue of the strong electron-accepting nature of TCF unit (as a push-pull chromophore), this designed sensor material can selectively detect Hg2+ over various tested metal ions in a 100% aqueous medium via naked-eye and photoluminescence (PL) observations. Theoretical and time-resolved photoluminescence measurements further confirmed the selectivity and reversibility of the probe towards Hg2+ via intramolocular charge transfer mechanism in this sensor material. Moreover, the living cell tests by confocal fluorescence images of this sensor material towards Hg2+ were also investigated. Finally, distinguished absorption changes and fluorescence quenching spectral appearances allowed us to present the selective optical indicator of Hg2+ via TCF moiety for the first time.

AB - A new red-fluorescent mercury ion sensor material is designed and synthesized, which is composed of a tweezer-shaped hydrophilic probe containing bifurcated soft-base atoms N and S coupled with 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) unit. By virtue of the strong electron-accepting nature of TCF unit (as a push-pull chromophore), this designed sensor material can selectively detect Hg2+ over various tested metal ions in a 100% aqueous medium via naked-eye and photoluminescence (PL) observations. Theoretical and time-resolved photoluminescence measurements further confirmed the selectivity and reversibility of the probe towards Hg2+ via intramolocular charge transfer mechanism in this sensor material. Moreover, the living cell tests by confocal fluorescence images of this sensor material towards Hg2+ were also investigated. Finally, distinguished absorption changes and fluorescence quenching spectral appearances allowed us to present the selective optical indicator of Hg2+ via TCF moiety for the first time.

KW - Aqueous medium

KW - ICT

KW - Living cell

KW - Push-pull chromophore

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