TY - JOUR
T1 - A genetic association study of activated partial thromboplastin time in European Americans and African Americans
T2 - The ARIC Study
AU - Weng, Lu Chen
AU - Cushman, Mary
AU - Pankow, James S.
AU - Basu, Saonli
AU - Boerwinkle, Eric
AU - Folsom, Aaron R.
AU - Tang, Weihong
N1 - Publisher Copyright:
© The Author 2014.
PY - 2015/4/15
Y1 - 2015/4/15
N2 - Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ~50 000 SNPs in ~2000 candidate genes. In EAs, the analyses identified a newindependent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10-8), which clusters with a coding variant rs6030 (P-value = 7.8 × 10-7). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signalswere identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10-6) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT.
AB - Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ~50 000 SNPs in ~2000 candidate genes. In EAs, the analyses identified a newindependent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10-8), which clusters with a coding variant rs6030 (P-value = 7.8 × 10-7). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signalswere identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10-6) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT.
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U2 - 10.1093/hmg/ddu732
DO - 10.1093/hmg/ddu732
M3 - Article
C2 - 25552651
AN - SCOPUS:84926435580
SN - 0964-6906
VL - 24
SP - 2401
EP - 2408
JO - Human molecular genetics
JF - Human molecular genetics
IS - 8
ER -