A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network

Dabeeru C. Rao, Michael A. Province, Mark F. Leppert, Al Oberman, Gerardo Heiss, R. Curt Ellison, Donna K. Arnett, John H. Eckfeldt, Karen Schwander, Steve C. Mockrin, Steve C. Hunt

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
JournalAmerican journal of hypertension
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Genetics
  • Hypertension
  • Linkage

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