A guide to murine platelet structure, function, assays, and genetic alterations

M. Jirouskova, A. S. Shet, Gerard J. Johnson

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Platelets play an important role in hemostasis, thrombosis and several other biological processes. The adaptability of mice to genetic manipulation and their genetic similarity to humans has resulted in a plethora of murine models to study platelet function. Although murine platelets differ from human platelets with regard to size, number and structure, functionally they are very similar. Thus, studies which employed these model systems have greatly improved our current understanding of the contribution of platelets to hemostasis and thrombosis. This review presents general recommendations with respect to collection, isolation and processing of murine platelets. It also describes the assays currently available to study platelet function and critically assesses their utility. The extensive literature on the effects of genetic alterations on murine platelet function is considered in detail. This review is intended to provide a convenient source of reference for platelet investigators.

Original languageEnglish (US)
Pages (from-to)661-669
Number of pages9
JournalJournal of Thrombosis and Haemostasis
Volume5
Issue number4
DOIs
StatePublished - Apr 2007

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