Abstract
When arachidonic acid is reacted with Fe2+, the Fe2+ is oxidized to Fe3+, and lipid peroxides are formed as detected by absorption at 232 nm. However, there is a large discrepancy between the amount of arachidonic acid converted to stable oxidized products and the amount of Fe2+ converted to Fe3+. We suggest that under appropriate conditions, electrons from the ferrous iron may reduce oxygen to superoxide in the presence of arachidonic acid. The results are consistent with evidence using bromophenacyl-bromide suggesting that release of fatty acids from cell phospholipids might by required for phagocytes to synthesize superoxide.
Original language | English (US) |
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Pages (from-to) | 1389-1395 |
Number of pages | 7 |
Journal | Medical Hypotheses |
Volume | 7 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1981 |
Bibliographical note
Funding Information:We gratefully acknowledge the support of grant MA-7396 from The Medical Research Council of Canada and USPHS grant AM12466 to Dr. S. Schwartz. JMG is the recipient of a Canadian MRC scholarship.
Keywords
- Arachidonic Acid
- Iron
- Leukocytes
- Superoxide