A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia

Stephen J. Wood, Dennis Velakoulis, Deidre J. Smith, David Bond, Geoff W. Stuart, Patrick D. McGorry, Warrick J. Brewer, Nicola Bridle, Jackie Eritaia, Patricia Desmond, Bruce Singh, David Copolov, Christos Pantelis

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean follow-up interval=1.9 years, range 0.54-4.18 years) and 12 with chronic schizophrenia (mean follow-up interval=2.3 years, range 1.03-4.12 years) and compared to 26 comparison subjects (mean follow-up interval 2.2 years, range 0.86-4.18 years). Hippocampal, temporal lobe, whole-brain and intracranial volumes (ICV) were estimated from high-resolution magnetic resonance images. Only whole-brain volume showed significant loss over the follow-up interval in both patient groups. The rate of this volume loss was not different in the first episode group compared to the chronic group. There were no changes in either hippocampal or temporal lobe volumes. The negative findings for the hippocampus and temporal lobes may mean that the abnormalities in these regions are stable features of schizophrenia. Alternatively, the period before the onset of frank psychotic symptoms may be the point of greatest risk for progressive change.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalSchizophrenia Research
Issue number1-2
StatePublished - Oct 1 2001

Bibliographical note

Funding Information:
The authors would like to thank Tabasum Hussein for assistance with the intracranial volume measurements. Dr Wood is currently supported as a National Health and Medical Research Council Research Officer and Dr Stuart as a NARSAD Young Investigator. This research was supported by the Mental Health Research Institute, the National Health and Medical Research Council (Nos: 970598 and 981112), the Australian Communications and Computing Institute, the Jack Brockhoff Foundation, the Ian Potter Foundation, the L. E. W. Carty Trust, the Woods Family Trust and the Percy Baxter Charitable Trust, Melbourne, Australia.

Copyright 2007 Elsevier B.V., All rights reserved.


  • Hippocampus
  • MRI
  • Neurodegeneration
  • Schizophrenia
  • Volumetry

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