A magnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy

Evan A. Weitz, Cutler Lewandowski, Eric D. Smolensky, Małgorzata Marjańska, Valérie C. Pierre

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We present the design and synthesis of a responsive magnetoplasmonic assembly for copper(I) which allows monitoring of the concentration of the metal both in three dimensions by magnetic resonance imaging and with high spatial resolution by dark field microscopy. The probe consists of azide-functionalized iron oxide nanoparticles 11.6 nm in diameter and acetylene-terminated gold nanoparticles 44 nm in diameter that form three-dimensional networks of intermingled magnetic and plasmonic nanoparticles in the presence of copper. This aggregation results in a decrease in longitudinal relaxivity, and an initial increase followed by a sharp decrease in transverse relaxivity, a change observable both by T1- and T2-weighted images, concomitantly with a decrease of surface plasmon resonance intensity.

Original languageEnglish (US)
Pages (from-to)5842-5849
Number of pages8
JournalACS nano
Volume7
Issue number7
DOIs
StatePublished - Jul 23 2013

Keywords

  • copper
  • dark field microscopy
  • gold nanoparticle
  • iron oxide nanoparticle
  • magnetic resonance imaging

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