A magnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy

Evan A. Weitz; Cutler Lewandowski; Eric D. Smolensky; Małgorzata Marjańska; Valérie C. Pierre

doi:10.1021/nn400928z

A magnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy

Evan A. Weitz, Cutler Lewandowski, Eric D. Smolensky, Małgorzata Marjańska, Valérie C. Pierre

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Abstract

We present the design and synthesis of a responsive magnetoplasmonic assembly for copper(I) which allows monitoring of the concentration of the metal both in three dimensions by magnetic resonance imaging and with high spatial resolution by dark field microscopy. The probe consists of azide-functionalized iron oxide nanoparticles 11.6 nm in diameter and acetylene-terminated gold nanoparticles 44 nm in diameter that form three-dimensional networks of intermingled magnetic and plasmonic nanoparticles in the presence of copper. This aggregation results in a decrease in longitudinal relaxivity, and an initial increase followed by a sharp decrease in transverse relaxivity, a change observable both by T₁- and T₂-weighted images, concomitantly with a decrease of surface plasmon resonance intensity.

Original language	English (US)
Pages (from-to)	5842-5849
Number of pages	8
Journal	ACS nano
Volume	7
Issue number	7
DOIs	https://doi.org/10.1021/nn400928z
State	Published - Jul 23 2013

Keywords

copper
dark field microscopy
gold nanoparticle
iron oxide nanoparticle
magnetic resonance imaging

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AU - Pierre, Valérie C.

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A magnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy

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