This paper describes a method to provide improved probability estimates that exposure to a specific dose of an airborne infectious pathogen will result in animal infection. Individual animals were exposed to a specific dose of airborne pathogen. Following exposure, animals were individually housed and monitored for evidence of infection. The detection of specific antibodies and/or the pathogen in diagnostic specimens was evidence that the exposure dose resulted in infection. If replicated over a range of doses, the results can be used to derive a dose-response curve for a variety of animal species and infectious pathogens. This information is useful in estimating the likelihood of infection associated with exposure to airborne infectious microorganisms. Applications include predicting the risk of transmission associated with exposure to airborne pathogens, modeling the transmission of airborne pathogens, and determining requirements for effective exposure doses for vaccines delivered in aerosols.
Bibliographical noteFunding Information:
This research project was funded in part by the PRRS Coordinated Agricultural Project (USDA: CSREES National Research Initiative, Competitive Grants Program) and National Pork Board Check-Off Dollars (NPB Project #04-206). Special thanks to Mike Harper and Terry Herrman (Ames Laboratory, Iowa State University) for engineering the construction of the DAT and the DAT containment system.
- Airborne transmission
- Infectious dose
- PRRS virus