Abstract
An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple "order of addition" of a pair of olefinic-alcohol components to a pseudo-C2 -symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.
Original language | English (US) |
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Pages (from-to) | 2332-2337 |
Number of pages | 6 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 10 |
DOIs | |
State | Published - Oct 7 2014 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2014 Hanson et al; licensee Beilstein-Institut.
Keywords
- One-pot
- Organophosphorus
- Phosphate-tether
- Polyol
- Sequential processes
- Stereodivergent