A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction

Dalin Tang; Chun Yang; Tal Geva; Rahul Rathod; Haruo Yamauchi; Vasu Gooty; Alexander Tang; Mehmet H. Kural; Kristen L. Billiar; Glenn Gaudette; Pedro J. Del Nido

doi:10.1016/j.compstruc.2012.11.016

A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction

Dalin Tang, Chun Yang, Tal Geva, Rahul Rathod, Haruo Yamauchi, Vasu Gooty, Alexander Tang, Mehmet H. Kural, Kristen L. Billiar, Glenn Gaudette, Pedro J. Del Nido

Pediatrics - Pediatric Cardiology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.

Original language	English (US)
Pages (from-to)	78-87
Number of pages	10
Journal	Computers and Structures
Volume	122
DOIs	https://doi.org/10.1016/j.compstruc.2012.11.016
State	Published - 2013

Bibliographical note

Funding Information:
This research was supported in part by NIH-1R01-HL 089269 (del Nido, Tang, Geva), NIH–HL63095 (PI: del Nido) and NIH-NHLBI 5P50HL074734 (PI: Geva; Co-Investigator: del Nido). Chun Yang’s research is supported in part by National Sciences Foundation of China 11171030 and the Fundamental Research Funds for the Central Universities .

Keywords

Congenital heart disease
Fluid-structural interaction
Heart model
Multiscale
Pulmonary valve replacement
Right ventricle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Tang, D., Yang, C., Geva, T., Rathod, R., Yamauchi, H., Gooty, V., Tang, A., Kural, M. H., Billiar, K. L., Gaudette, G., & Del Nido, P. J. (2013). A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction. Computers and Structures, 122, 78-87. https://doi.org/10.1016/j.compstruc.2012.11.016

Tang, D, Yang, C, Geva, T, Rathod, R, Yamauchi, H, Gooty, V, Tang, A, Kural, MH, Billiar, KL, Gaudette, G & Del Nido, PJ 2013, 'A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction', Computers and Structures, vol. 122, pp. 78-87. https://doi.org/10.1016/j.compstruc.2012.11.016

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abstract = "Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.",

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author = "Dalin Tang and Chun Yang and Tal Geva and Rahul Rathod and Haruo Yamauchi and Vasu Gooty and Alexander Tang and Kural, {Mehmet H.} and Billiar, {Kristen L.} and Glenn Gaudette and {Del Nido}, {Pedro J.}",

note = "Funding Information: This research was supported in part by NIH-1R01-HL 089269 (del Nido, Tang, Geva), NIH–HL63095 (PI: del Nido) and NIH-NHLBI 5P50HL074734 (PI: Geva; Co-Investigator: del Nido). Chun Yang{\textquoteright}s research is supported in part by National Sciences Foundation of China 11171030 and the Fundamental Research Funds for the Central Universities .",

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AU - Yamauchi, Haruo

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AU - Tang, Alexander

AU - Kural, Mehmet H.

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AU - Gaudette, Glenn

AU - Del Nido, Pedro J.

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AB - Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.

KW - Congenital heart disease

KW - Fluid-structural interaction

KW - Heart model

KW - Multiscale

KW - Pulmonary valve replacement

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A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction

Abstract

Bibliographical note

Keywords

UN SDGs

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