A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome

Sara T. Kover; Elizabeth I. Pierpont; Jee Seon Kim; W. Ted Brown; Leonard Abbeduto

doi:10.1080/87565641.2013.820305

A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome

Sara T. Kover, Elizabeth I. Pierpont, Jee Seon Kim, W. Ted Brown, Leonard Abbeduto

Pediatrics - Neuropsychology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N = 53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.

Original language	English (US)
Pages (from-to)	445-460
Number of pages	16
Journal	Developmental Neuropsychology
Volume	38
Issue number	7
DOIs	https://doi.org/10.1080/87565641.2013.820305
State	Published - Oct 1 2013

Bibliographical note

Funding Information:
This research was supported by NIH grants R01 HD024356 and P30 HD003352 to Leonard Abbeduto and the Waisman Center, respectively, in addition to NIH F31 DC010959 awarded to the first author. Correspondence should be addressed to Sara T. Kover, Ph.D., Waisman Center, 1500 Highland Avenue, Room 475, Madison, WI 53705. E-mail: kover@wisc.edu

Access

10.1080/87565641.2013.820305

OpenUrl availability

Full text

Cite this

@article{8a4eb31d9c3d41f0b3d74ea7bf62160b,

title = "A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome",

abstract = "This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N = 53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.",

author = "Kover, {Sara T.} and Pierpont, {Elizabeth I.} and Kim, {Jee Seon} and {Ted Brown}, W. and Leonard Abbeduto",

note = "Funding Information: This research was supported by NIH grants R01 HD024356 and P30 HD003352 to Leonard Abbeduto and the Waisman Center, respectively, in addition to NIH F31 DC010959 awarded to the first author. Correspondence should be addressed to Sara T. Kover, Ph.D., Waisman Center, 1500 Highland Avenue, Room 475, Madison, WI 53705. E-mail: kover@wisc.edu",

year = "2013",

month = oct,

day = "1",

doi = "10.1080/87565641.2013.820305",

language = "English (US)",

volume = "38",

pages = "445--460",

journal = "Developmental Neuropsychology",

issn = "8756-5641",

publisher = "Psychology Press Ltd",

number = "7",

}

TY - JOUR

T1 - A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome

AU - Kover, Sara T.

AU - Pierpont, Elizabeth I.

AU - Kim, Jee Seon

AU - Ted Brown, W.

AU - Abbeduto, Leonard

N1 - Funding Information: This research was supported by NIH grants R01 HD024356 and P30 HD003352 to Leonard Abbeduto and the Waisman Center, respectively, in addition to NIH F31 DC010959 awarded to the first author. Correspondence should be addressed to Sara T. Kover, Ph.D., Waisman Center, 1500 Highland Avenue, Room 475, Madison, WI 53705. E-mail: kover@wisc.edu

PY - 2013/10/1

Y1 - 2013/10/1

N2 - This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N = 53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.

AB - This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N = 53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.

UR - http://www.scopus.com/inward/record.url?scp=84887467618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887467618&partnerID=8YFLogxK

U2 - 10.1080/87565641.2013.820305

DO - 10.1080/87565641.2013.820305

M3 - Article

C2 - 24138215

AN - SCOPUS:84887467618

SN - 8756-5641

VL - 38

SP - 445

EP - 460

JO - Developmental Neuropsychology

JF - Developmental Neuropsychology

IS - 7

ER -

A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this