A new era for improving cardiothoracic transplantations

Andrew W. Shaffer; Lars M. Mattison; John R. Spratt; Tinen L. Iles; Natalie Kerns; Michael G. Bateman; Stephen J. Huddleston; Rosemary F. Kelly; Ranjit John; Kenneth K. Liao; Paul A. Iaizzo

doi:10.1016/B978-0-12-813068-1.00003-8

A new era for improving cardiothoracic transplantations

Andrew W. Shaffer, Lars M. Mattison, John R. Spratt, Tinen L. Iles, Natalie Kerns, Michael G. Bateman, Stephen J. Huddleston, Rosemary F. Kelly, Ranjit John, Kenneth K. Liao, Paul A. Iaizzo

Surgery

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Abstract

Cardiothoracic transplantation research dates back to the late 1800s, yet the first human heart transplantation did not occur until 1967. Today, more and more centers worldwide are performing such procedures with increasing success, long-term survival rates, and, importantly, with an improved quality of life for recipients. Much work remains to increase the number of available hearts and lungs for these transplants, but progress is being made for many reasons that are discussed in this chapter. The use of ex vivo lung and heart perfusion technologies along with pharmacological advancements (e.g., preservation solutions) has expanded the time available between organ recovery and transplantation, allowing for enhanced functional assessment and providing a platform for therapeutic delivery. In this chapter, we provide a brief history of cardiothoracic transplantation, review the current state of transplantation procedures, and discuss future directions for research and technological advancements.

Original language	English (US)
Title of host publication	Engineering in Medicine
Subtitle of host publication	Advances and Challenges
Publisher	Elsevier
Pages	55-82
Number of pages	28
ISBN (Electronic)	9780128130681
ISBN (Print)	9780128135143
DOIs	https://doi.org/10.1016/B978-0-12-813068-1.00003-8
State	Published - Jan 1 2018

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© 2019 Elsevier Inc. All rights reserved.

Keywords

Donation after cardiac death (DCD)
EXPAND Heart trial
End-stage heart failure
Ex vivo perfusion
Heart transplantation
INSPIRE trial
Lung transplantation
Organ donation
PROCEED II trial
REVIVE trial

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abstract = "Cardiothoracic transplantation research dates back to the late 1800s, yet the first human heart transplantation did not occur until 1967. Today, more and more centers worldwide are performing such procedures with increasing success, long-term survival rates, and, importantly, with an improved quality of life for recipients. Much work remains to increase the number of available hearts and lungs for these transplants, but progress is being made for many reasons that are discussed in this chapter. The use of ex vivo lung and heart perfusion technologies along with pharmacological advancements (e.g., preservation solutions) has expanded the time available between organ recovery and transplantation, allowing for enhanced functional assessment and providing a platform for therapeutic delivery. In this chapter, we provide a brief history of cardiothoracic transplantation, review the current state of transplantation procedures, and discuss future directions for research and technological advancements.",

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AU - Mattison, Lars M.

AU - Spratt, John R.

AU - Iles, Tinen L.

AU - Kerns, Natalie

AU - Bateman, Michael G.

AU - Huddleston, Stephen J.

AU - Kelly, Rosemary F.

AU - John, Ranjit

AU - Liao, Kenneth K.

AU - Iaizzo, Paul A.

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AB - Cardiothoracic transplantation research dates back to the late 1800s, yet the first human heart transplantation did not occur until 1967. Today, more and more centers worldwide are performing such procedures with increasing success, long-term survival rates, and, importantly, with an improved quality of life for recipients. Much work remains to increase the number of available hearts and lungs for these transplants, but progress is being made for many reasons that are discussed in this chapter. The use of ex vivo lung and heart perfusion technologies along with pharmacological advancements (e.g., preservation solutions) has expanded the time available between organ recovery and transplantation, allowing for enhanced functional assessment and providing a platform for therapeutic delivery. In this chapter, we provide a brief history of cardiothoracic transplantation, review the current state of transplantation procedures, and discuss future directions for research and technological advancements.

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KW - End-stage heart failure

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ER -

A new era for improving cardiothoracic transplantations

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