TY - JOUR
T1 - A new immune-competent animal model of mucosally derived squamous cell carcinoma
AU - Djalilian, Hamid R.
AU - Lessan, Khashayar
AU - Grami, Vahid
AU - Pambuccian, Stefan E.
AU - Spellman, Stephen R.
AU - Low, Walter C.
AU - Hall, Walter A.
AU - Ondrey, Frank G.
N1 - Funding Information:
Supported by the American Academy of Otolaryngology–Head and Neck Surgery Foundation Resident Research Award.
PY - 2004/11
Y1 - 2004/11
N2 - Objectives To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA). Study design Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 × 106 FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis. Results All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases. Conclusion The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer. Significance The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals. EBM rating: B-3.
AB - Objectives To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA). Study design Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 × 106 FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis. Results All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph node metastases. Conclusion The FAT7 flank tumor in Fischer 344 rats is a new animal model that closely resembles the behavior of human mucosal head and neck cancer. Significance The existence of an immune-competent, mucosally derived, and reliable animal model of SCCA that somewhat resembles human head and neck SCCA gives the opportunity to perform immune-modulating experiments on head and neck cancer in these animals. EBM rating: B-3.
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U2 - 10.1016/j.otohns.2004.01.014
DO - 10.1016/j.otohns.2004.01.014
M3 - Article
C2 - 15523466
AN - SCOPUS:7444253530
SN - 0194-5998
VL - 131
SP - 781
EP - 783
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 5
ER -
