TY - JOUR
T1 - A new index for discrimination between iron deficiency anemia and beta-thalassemia minor
T2 - Results in 284 patients
AU - Ehsani, M. A.
AU - Shahgholi, E.
AU - Rahiminejad, M. S.
AU - Seighali, F.
AU - Rashidi, A.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - The present study reports the results in 284 patients of applying a recently developed index, MCV -(1 O×RBC), for discrimination between beta-thalassemia trait (β-TT) and Iron Deficiency Anemia (IDA), the two most common causes of microcytic hypochromic anemias. A total of 284 carefully selected patients (130 patients with FDA and 154 with β-TT) were studied. Sensitivity, specificity and Youden's index were compared between the proposed index and four other indices, namely England-Fraser, Mentzer, Srivastava and RBC count. The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. The best discrimination index according to Youden's criteria was Mentzer (Youden's index = 90.1) followed by the new index (Youden's index = 85.5). There are remarkable inconsistencies among the results obtained in different studies. Larger studies are needed to establish the optimal discrimination index as well as to confirm the results obtained in the present study. Nevertheless, the epidemiological indices of the proposed discrimination index and the simplicity of its calculation make it acceptable for use in Iran.
AB - The present study reports the results in 284 patients of applying a recently developed index, MCV -(1 O×RBC), for discrimination between beta-thalassemia trait (β-TT) and Iron Deficiency Anemia (IDA), the two most common causes of microcytic hypochromic anemias. A total of 284 carefully selected patients (130 patients with FDA and 154 with β-TT) were studied. Sensitivity, specificity and Youden's index were compared between the proposed index and four other indices, namely England-Fraser, Mentzer, Srivastava and RBC count. The new index correctly identified 263 (92.96%) patients, standing inferior only to Mentzer which correctly diagnosed 269 (94.71%) patients. The best discrimination index according to Youden's criteria was Mentzer (Youden's index = 90.1) followed by the new index (Youden's index = 85.5). There are remarkable inconsistencies among the results obtained in different studies. Larger studies are needed to establish the optimal discrimination index as well as to confirm the results obtained in the present study. Nevertheless, the epidemiological indices of the proposed discrimination index and the simplicity of its calculation make it acceptable for use in Iran.
KW - Beta-thalassemia
KW - Discrimination index
KW - Iron deficiency anemia
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U2 - 10.3923/pjbs.2009.473.475
DO - 10.3923/pjbs.2009.473.475
M3 - Article
C2 - 19579993
AN - SCOPUS:67649972473
SN - 1028-8880
VL - 12
SP - 473
EP - 475
JO - Pakistan Journal of Biological Sciences
JF - Pakistan Journal of Biological Sciences
IS - 5
ER -