A new role for vitamin D: The enhancement of oncolytic viral therapy in pancreatic cancer

Christopher J. LaRocca, Susanne G. Warner

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Oncolytic viruses have emerged as a novel class of anti-cancer therapeutics with one virus already receiving United States Food and Drug Administration (FDA) approval (talimogene laherparepvec) and many others undergoing testing in clinical trials. These viruses have direct lytic effects on tumor cells as well as immunomodulatory functions to increase inflammatory cell infiltrates in the tumor microenvironment. Despite all of the advances in cancer care, pancreatic cancer remains a highly lethal malignancy. One of the main barriers to successful systemic treatment of the disease is the fibrotic tumor stroma, as the unique extracellular matrix creates an environment that promotes tumor growth and is resistant to chemotherapy and other anti-cancer agents. The pleiotropic effects of Vitamin D have been widely studied, but recent research has now demonstrated it to be an effective agent in modulating pancreatic cancer stroma to facilitate the enhanced delivery of cytotoxic chemotherapy and immunogenicity in response to treatment. This review will explore the combination of Vitamin D with oncolytic viruses and how this novel application of Vitamin D's ability to modulate pancreatic tumor stroma may result in a potential mechanism for increasing the efficacy of oncolytic virotherapy in pancreatic cancer.

Original languageEnglish (US)
Article number104
JournalBiomedicines
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Bibliographical note

Funding Information:
This work is supported by the American Cancer Society Mentored Research Scholar Grant: MRSG-16-047-01-MPC (SGW).

Publisher Copyright:
© 2018 by the authors.

Keywords

  • Oncolytic virus
  • Pancreatic cancer
  • Paricalcitol
  • Virotherapy
  • Vitamin D

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