A new synthesis of N‐substituted‐2‐alkyl(or aryl)quinazolin‐4‐amines by amide base‐mediated cyclization of carbox‐imidamides derived from 2‐(trifluoromethyl)benzenamine

Steven E. Patterson, Lubomir Janda, Lucjan Strekowski

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A one‐pot preparation of carboximidamides (amidines) 11–14 involves treatment of amides 2–5 with phosphorus pentachloride followed by the treatment of the resultant crude imidoyl chlorides 7–10 with ammonia. Amidines 11–14 are cyclized to quinazolines 20–26 in lithium alkylamide‐or dialkylamide‐mediated reactions.

Original languageEnglish (US)
Pages (from-to)703-706
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume29
Issue number4
DOIs
StatePublished - Jul 1992

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