A new synthesis of N‐substituted‐2‐alkyl(or aryl)quinazolin‐4‐amines by amide base‐mediated cyclization of carbox‐imidamides derived from 2‐(trifluoromethyl)benzenamine

Steven E. Patterson; Lubomir Janda; Lucjan Strekowski

doi:10.1002/jhet.5570290405

A new synthesis of N‐substituted‐2‐alkyl(or aryl)quinazolin‐4‐amines by amide base‐mediated cyclization of carbox‐imidamides derived from 2‐(trifluoromethyl)benzenamine

Steven E. Patterson, Lubomir Janda, Lucjan Strekowski

Center for Drug Design

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12 Scopus citations

Abstract

A one‐pot preparation of carboximidamides (amidines) 11–14 involves treatment of amides 2–5 with phosphorus pentachloride followed by the treatment of the resultant crude imidoyl chlorides 7–10 with ammonia. Amidines 11–14 are cyclized to quinazolines 20–26 in lithium alkylamide‐or dialkylamide‐mediated reactions.

Original language	English (US)
Pages (from-to)	703-706
Number of pages	4
Journal	Journal of Heterocyclic Chemistry
Volume	29
Issue number	4
DOIs	https://doi.org/10.1002/jhet.5570290405
State	Published - Jul 1992

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A new synthesis of N‐substituted‐2‐alkyl(or aryl)quinazolin‐4‐amines by amide base‐mediated cyclization of carbox‐imidamides derived from 2‐(trifluoromethyl)benzenamine. / Patterson, Steven E.; Janda, Lubomir; Strekowski, Lucjan.
In: Journal of Heterocyclic Chemistry, Vol. 29, No. 4, 07.1992, p. 703-706.

Research output: Contribution to journal › Article › peer-review

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A new synthesis of N‐substituted‐2‐alkyl(or aryl)quinazolin‐4‐amines by amide base‐mediated cyclization of carbox‐imidamides derived from 2‐(trifluoromethyl)benzenamine

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