Taladegib (LY-2940680), a small molecule Hedgehog signalling pathway inhibitor, was obtained from N-benzyl-4-piperidone via Borch reductive amination, acylation with 4-fluoro-2-(trifluoromethyl)benzoyl chloride, debenzylation, substitution with 1,4-dichlorophthalazine and Suzuki cross-coupling reaction with 1-methyl-1H-pyrazole-5-boronic acid. The advantages of this synthesis route were the elimination of Boc protection and deprotection and the inexpensive starting materials. Furthermore, the debenzylation reaction was achieved with simplified operational procedure using ammonium formate as hydrogen source that provided high reaction yield. This synthetic procedure was suitable for large-scale production of the compound for biological evaluation and further study.
Bibliographical noteFunding Information:
This work is supported by The Fundamental Research Funds for the Central Universities (2242014R30019), Natural Science Foundation of Jiangsu Province (BK20161438), National High Technology Research and Development Program of China (No. 2013AA032205)
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- Hedgehog signalling pathway
- Taladegib (LY-2940680)