A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy- (10α-2H)paclitaxel

Dinah Dutta; Harry Hadd; David G. Vander Velde; Gunda I. Georg

doi:10.1016/S0960-894X(99)00609-5

A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy- (10α-²H)paclitaxel

Dinah Dutta, Harry Hadd, David G. Vander Velde, Gunda I. Georg

Medicinal Chemistry

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Abstract

10-Deacetoxy-(10α-²H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D₂O.

Original language	English (US)
Pages (from-to)	3277-3278
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(99)00609-5
State	Published - Dec 6 1999

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title = "A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy- (10α-2H)paclitaxel",

abstract = "10-Deacetoxy-(10α-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.",

author = "Dinah Dutta and Harry Hadd and {Vander Velde}, {David G.} and Georg, {Gunda I.}",

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AU - Hadd, Harry

AU - Vander Velde, David G.

AU - Georg, Gunda I.

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A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy- (10α-²H)paclitaxel

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